Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes

[1]  William L. Hamilton,et al.  An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples. , 2021, Wellcome open research.

[2]  T. Bousema,et al.  A portfolio of geographically distinct laboratory-adapted Plasmodium falciparum clones with consistent infection rates in Anopheles mosquitoes , 2021, Malaria journal.

[3]  N. Tolia,et al.  A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes , 2021, Nature Communications.

[4]  P. Scaria,et al.  Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice , 2021, The Journal of clinical investigation.

[5]  D. Carter,et al.  Reassessing therapeutic antibodies for neglected and tropical diseases , 2020, PLoS neglected tropical diseases.

[6]  T. Bousema,et al.  Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites , 2019, Immunological reviews.

[7]  W. Schief,et al.  Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25 , 2019, Nature Communications.

[8]  G. van Gemert,et al.  Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum , 2019, Front. Immunol..

[9]  Simon C. Potter,et al.  The EMBL-EBI search and sequence analysis tools APIs in 2019 , 2019, Nucleic Acids Res..

[10]  C. King,et al.  Expression and purification optimization of an N-terminal Pfs230 transmission-blocking vaccine candidate , 2019, Protein expression and purification.

[11]  T. Bousema,et al.  Two-Faced Immunity? The Evidence for Antibody Enhancement of Malaria Transmission. , 2019, Trends in parasitology.

[12]  T. Bousema,et al.  Plasmodium falciparum Gametocyte Enrichment in Peripheral Blood Samples by Magnetic Fractionation: Gametocyte Yields and Possibilities to Reuse Columns , 2019, The American journal of tropical medicine and hygiene.

[13]  A. Semesi,et al.  Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45 , 2018, Nature Communications.

[14]  C. Ockenhouse,et al.  Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults , 2018, Vaccine.

[15]  Erin E Gabriel,et al.  Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults. , 2018, The Lancet. Infectious diseases.

[16]  D. Wirth,et al.  Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding☆ , 2018, International journal for parasitology.

[17]  Alex B. Miller,et al.  Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite , 2018, Nature Medicine.

[18]  V. A. Stewart,et al.  A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity , 2017, Malaria Journal.

[19]  J. Bailey,et al.  SeekDeep: single-base resolution de novo clustering for amplicon deep sequencing , 2017, Nucleic acids research.

[20]  B. F. Hall,et al.  malERA: An updated research agenda for malaria elimination and eradication , 2017, PLoS medicine.

[21]  M. Mathieu,et al.  IgG Fc engineering to modulate antibody effector functions , 2017, Protein & Cell.

[22]  M. Huynen,et al.  Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial , 2017, BMC Medicine.

[23]  T. Lefèvre,et al.  Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations , 2017, Scientific Reports.

[24]  P. V. van Genderen,et al.  Infectivity of Plasmodium falciparum sporozoites determines emerging parasitemia in infected volunteers , 2017, Science Translational Medicine.

[25]  M. Fay,et al.  Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults , 2016, PloS one.

[26]  X. Ambroggio,et al.  Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230* , 2016, The Journal of Biological Chemistry.

[27]  Dennis R Burton,et al.  Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design. , 2016, Annual review of immunology.

[28]  T. Bousema,et al.  Transmission blocking malaria vaccines: Assays and candidates in clinical development. , 2015, Vaccine.

[29]  A. Nicosia,et al.  Comparative Assessment of Transmission-Blocking Vaccine Candidates against Plasmodium falciparum , 2015, Scientific Reports.

[30]  T. Bousema,et al.  The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays , 2013, Scientific Reports.

[31]  X. Su,et al.  Anti-Pfs25 Human Plasma Reduces Transmission of Plasmodium falciparum Isolates That Have Diverse Genetic Backgrounds , 2013, Infection and Immunity.

[32]  M. Fay,et al.  Qualification of Standard Membrane-Feeding Assay with Plasmodium falciparum Malaria and Potential Improvements for Future Assays , 2013, PloS one.

[33]  S. Hoffman,et al.  NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections , 2012, The Journal of infectious diseases.

[34]  R. Sinden,et al.  Measuring the blockade of malaria transmission--an analysis of the Standard Membrane Feeding Assay. , 2012, International journal for parasitology.

[35]  T. Tsuboi,et al.  A Plant-Produced Pfs230 Vaccine Candidate Blocks Transmission of Plasmodium falciparum , 2011, Clinical and Vaccine Immunology.

[36]  O. Doumbo,et al.  Blood stage vaccines for Plasmodium falciparum , 2010, Human vaccines.

[37]  Eileen Kraemer,et al.  PlasmoDB: a functional genomic database for malaria parasites , 2008, Nucleic Acids Res..

[38]  M. Fay,et al.  Phase 1 Trial of Malaria Transmission Blocking Vaccine Candidates Pfs25 and Pvs25 Formulated with Montanide ISA 51 , 2008, PloS one.

[39]  Didier Fontenille,et al.  Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiae and Anopheles funestus , 2007, Proceedings of the National Academy of Sciences.

[40]  Siarhei Maslau,et al.  Structural models for the protein family characterized by gamete surface protein Pfs230 of Plasmodium falciparum. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Leszek Rychlewski,et al.  FFAS03: a server for profile–profile sequence alignments , 2005, Nucleic Acids Res..

[42]  G. Crooks,et al.  WebLogo: a sequence logo generator. , 2004, Genome research.

[43]  D. Conway,et al.  Extreme geographical fixation of variation in the Plasmodium falciparum gamete surface protein gene Pfs48/45 compared with microsatellite loci. , 2001, Molecular and biochemical parasitology.

[44]  J. Meuwissen,et al.  Plasmodium falciparum: a comparison of the activity of Pfs230-specific antibodies in an assay of transmission-blocking immunity and specific competition ELISAs. , 1995, Experimental parasitology.

[45]  R. Sauerwein,et al.  Transmission blockade of Plasmodium falciparum malaria by anti-Pfs230-specific antibodies is isotype dependent , 1995, Infection and immunity.

[46]  J. Meis,et al.  A scanning electron microscopic study of the sporogonic development of Plasmodium falciparum in Anopheles stephensi. , 1992, Acta tropica.

[47]  R. Carter,et al.  Genetic hybrids of Plasmodium falciparum identified by amplification of genomic DNA from single oocysts. , 1991, Molecular and biochemical parasitology.

[48]  P. Barr,et al.  Recombinant Pfs25 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in experimental animals , 1991, The Journal of experimental medicine.

[49]  J. Meuwissen,et al.  Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes , 1989, Parasitology.

[50]  M. Smits,et al.  Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito , 1985, The Journal of experimental medicine.

[51]  R. Carter,et al.  Target antigens in malaria transmission blocking immunity. , 1984, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[52]  T. Burkot,et al.  Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum , 1983, The Journal of experimental medicine.

[53]  R. Sinden.  The cell biology of sexual development in Plasmodium , 1983, Parasitology.

[54]  R. Sauerwein,et al.  Plasmodium falciparum: production and characterization of rat monoclonal antibodies specific for the sexual-stage Pfs48/45 antigen. , 2001, Experimental parasitology.

[55]  I. Felger,et al.  Limited polymorphism in Plasmodium falciparum sexual-stage antigens. , 2001, The American journal of tropical medicine and hygiene.

[56]  R. Sinden.  Sexual development of malarial parasites. , 1983, Advances in parasitology.