Short Communication A Total Fibrinogen Deficiency Is Compatible with the Development of Pulmonary Fibrosis in Mice

In addition to their well-known roles in hemostasis,fibrinogen (Fg) and fibrin (Fn) have been implicatedin a number of other physiological and pathophysio-logical events. One of these involves the fibroprolif-erative response after acute lung injury, which is thefocus of the current study. Mice with a total Fg defi-ciency (

[1]  V. Ploplis,et al.  The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system. , 2000, The American journal of pathology.

[2]  S. Brennan,et al.  Hypofibrinogenemia in an individual with 2 coding (γ82 A→G and Bβ235 P→L) and 2 noncoding mutations , 2000 .

[3]  P. Mannucci,et al.  Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion. , 2000, Blood.

[4]  P. Carmeliet,et al.  Blood Coagulation Factor X Deficiency Causes Partial Embryonic Lethality and Fatal Neonatal Bleeding in Mice , 2000, Thrombosis and Haemostasis.

[5]  S. Lord,et al.  Hypofibrinogenemia Associated With a Heterozygous Missense Mutation γ153Cys to Arg (Matsumoto IV): In Vitro Expression Demonstrates Defective Secretion of the Variant Fibrinogen , 1999 .

[6]  M. Blajchman,et al.  The Procoagulant State of the VX-2 Tumor in Rabbit Lung In Vivo , 1999, Thrombosis and Haemostasis.

[7]  P. Carmeliet,et al.  Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. , 1998, The Journal of clinical investigation.

[8]  P. Carmeliet,et al.  Mice lacking factor VII develop normally but suffer fatal perinatal bleeding , 1997, Nature.

[9]  W. Kao,et al.  Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice. , 1997, Investigative ophthalmology & visual science.

[10]  T. Urano,et al.  Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis. , 1997, American journal of respiratory and critical care medicine.

[11]  Y. Itoh,et al.  Degradation of cross-linked fibrin by matrix metalloproteinase 3 (stromelysin 1): hydrolysis of the gamma Gly 404-Ala 405 peptide bond. , 1996, Biochemistry.

[12]  M. Olman,et al.  Polymerization of fibrinogen in murine bleomycin-induced lung injury. , 1996, The American journal of physiology.

[13]  H. Endo,et al.  A gamma Gly-268 to Glu substitution is responsible for impaired fibrin assembly in a homozygous dysfibrinogen Kurashiki I. , 1996, Blood.

[14]  F. Terasawa,et al.  Fibrinogen Matsumoto I: A γ364 Asp → His (GAT→CAT) Substitution Associated with Defective Fibrin Polymerization , 1996, Thrombosis and Haemostasis.

[15]  D. Loskutoff,et al.  Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. , 1995, The Journal of clinical investigation.

[16]  J. Degen,et al.  Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. , 1995, Genes & development.

[17]  G. Laurent,et al.  Partially degraded fibrin(ogen) stimulates fibroblast proliferation in vitro. , 1995, American journal of respiratory cell and molecular biology.

[18]  M. Fornaro,et al.  Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[19]  H. Dvorak,et al.  Pathogenesis of ascites tumor growth: fibrinogen influx and fibrin accumulation in tissues lining the peritoneal cavity. , 1995, Cancer research.

[20]  H. Dvorak,et al.  Pathogenesis of ascites tumor growth: vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation. , 1995, Cancer research.

[21]  V. Manninen,et al.  Severity of peripheral atherosclerosis is associated with fibrinogen and degradation of cross-linked fibrin. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

[22]  H. Rokita,et al.  Increased fibrinogen synthesis in mice during the acute phase response: co-operative interaction of interleukin 1, interleukin 6, and interleukin 1 receptor antagonist. , 1993, Cytokine.

[23]  L. Languino,et al.  Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway , 1993, Cell.

[24]  D. Altieri,et al.  The structural motif glycine 190-valine 202 of the fibrinogen gamma chain interacts with CD11b/CD18 integrin (alpha M beta 2, Mac-1) and promotes leukocyte adhesion. , 1993, The Journal of biological chemistry.

[25]  C. Redman,et al.  Identification of B beta chain domains involved in human fibrinogen assembly. , 1992, The Journal of biological chemistry.

[26]  S. Lord,et al.  Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA) , 1992 .

[27]  D. McRitchie,et al.  Effect of systemic fibrinogen depletion on intraabdominal abscess formation. , 1991, The Journal of laboratory and clinical medicine.

[28]  S. Mane,et al.  Fibrinogen Baltimore I: polymerization defect associated with a gamma 292Gly----Val (GGC----GTC) mutation. , 1990, Blood.

[29]  T. King,et al.  An immunohistochemical study of architectural remodeling and connective tissue synthesis in pulmonary fibrosis. , 1989, The American review of respiratory disease.

[30]  C. Francis,et al.  The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin. , 1989, Blood.

[31]  R. Hantgan LOCALIZATION OF THE DOMAINS OF FIBRIN INVOLVED IN BINDING TO PLATELETS , 1988, Thrombosis and Haemostasis.

[32]  C. Francis,et al.  Fibrinogen binding to human blood platelets: effect of gamma chain carboxyterminal structure and length. , 1986, Blood.

[33]  S. Yu,et al.  Fibrinogen precursors. Order of assembly of fibrinogen chains. , 1984, The Journal of biological chemistry.

[34]  S. Timmons,et al.  gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R. Doolittle Fibrinogen and fibrin. , 1981, Scientific American.

[36]  Jian-Zhong Zhang,et al.  Identification of B @ Chain Domains Involved in Human Fibrinogen Assembly * , 2001 .

[37]  S. Brennan,et al.  Hypofibrinogenemia in an individual with 2 coding (gamma82 A-->G and Bbeta235 P-->L) and 2 noncoding mutations. , 2000, Blood.

[38]  R. D. McCoy,et al.  Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. , 1996, The Journal of clinical investigation.

[39]  H. Dvorak,et al.  Fibroblast migration in fibrin gel matrices. , 1993, The American journal of pathology.

[40]  N. Kirschbaum,et al.  Characterization of the gamma chain platelet binding site on fibrinogen fragment D. , 1992, Blood.

[41]  S. Lord,et al.  Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA). , 1992, Blood.

[42]  Y. Nemerson,et al.  Zymogens and cofactors of blood coagulation. , 1980, CRC critical reviews in biochemistry.