Improving wheat to remove coeliac epitopes but retain functionality

[1]  Huw D Jones,et al.  Regulatory uncertainty over genome editing , 2015, Nature Plants.

[2]  P. Maness,et al.  The plasticity of cyanobacterial metabolism supports direct CO2 conversion to ethylene , 2015, Nature Plants.

[3]  B. Seabourn,et al.  Silencing of omega-5 gliadins in transgenic wheat eliminates a major source of environmental variability and improves dough mixing properties of flour , 2014, BMC Plant Biology.

[4]  C. Rosell,et al.  Cereals for developing gluten-free products and analytical tools for gluten detection , 2014 .

[5]  P. Shewry,et al.  Improving cereal grain carbohydrates for diet and health , 2014, Journal of cereal science.

[6]  L. Herrera-Estrella,et al.  An improved, low-cost, hydroponic system for growing Arabidopsis and other plant species under aseptic conditions , 2014, BMC Plant Biology.

[7]  C. Rosell,et al.  The Shutdown of Celiac Disease-Related Gliadin Epitopes in Bread Wheat by RNAi Provides Flours with Increased Stability and Better Tolerance to Over-Mixing , 2014, PloS one.

[8]  C. Rosell,et al.  Reduced-Gliadin Wheat Bread: An Alternative to the Gluten-Free Diet for Consumers Suffering Gluten-Related Pathologies , 2014, PloS one.

[9]  D. Lafiandra,et al.  Development of a TILLING resource in durum wheat for reverse- and forward-genetic analyses , 2014, Crop and Pasture Science.

[10]  L. Gilissen,et al.  Quantitative and qualitative differences in celiac disease epitopes among durum wheat varieties identified through deep RNA-amplicon sequencing , 2013, BMC Genomics.

[11]  D. Greenwood,et al.  Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis , 2013, BMJ.

[12]  Y. Gu,et al.  The gene space in wheat: the complete γ-gliadin gene family from the wheat cultivar Chinese Spring , 2013, Functional & Integrative Genomics.

[13]  Steven S Xu,et al.  Synthetic Hexaploids: Harnessing Species of the Primary Gene Pool for Wheat Improvement , 2013 .

[14]  Bao Liu,et al.  Structural genes of wheat and barley 5-methylcytosine DNA glycosylases and their potential applications for human health , 2012, Proceedings of the National Academy of Sciences.

[15]  Nidhi Rawat,et al.  A diploid wheat TILLING resource for wheat functional genomics , 2012, BMC Plant Biology.

[16]  Karl H. Mühling,et al.  Protein composition and techno-functional properties of transgenic wheat with reduced α-gliadin content obtained by RNA interference , 2012 .

[17]  Francisco Barro,et al.  The Introgression of RNAi Silencing of γ-Gliadins into Commercial Lines of Bread Wheat Changes the Mixing and Technological Properties of the Dough , 2012, PloS one.

[18]  C. Rosell,et al.  Significant down-regulation of γ-gliadins has minor effect on gluten and starch properties of bread wheat , 2012 .

[19]  M. Parry,et al.  Development and Characterization of a New TILLING Population of Common Bread Wheat (Triticum aestivum L.) , 2012, PloS one.

[20]  Ismael Padioleau,et al.  Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation , 2012, BMC Genomics.

[21]  A. Camarca,et al.  Repertoire of gluten peptides active in celiac disease patients: perspectives for translational therapeutic applications. , 2012, Endocrine, metabolic & immune disorders drug targets.

[22]  G. Fazio,et al.  Development of high amylose wheat through TILLING , 2012, BMC Plant Biology.

[23]  F. Koning,et al.  Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules , 2012, Immunogenetics.

[24]  Peter HR Green,et al.  Spectrum of gluten-related disorders: consensus on new nomenclature and classification , 2012, BMC Medicine.

[25]  R. Lau,et al.  Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies , 2011, BMJ : British Medical Journal.

[26]  F. Barro,et al.  Down-Regulating γ-Gliadins in Bread Wheat Leads to Non-Specific Increases in Other Gluten Proteins and Has No Major Effect on Dough Gluten Strength , 2011, PloS one.

[27]  T. Reunala,et al.  Prevalence and incidence of dermatitis herpetiformis: a 40‐year prospective study from Finland , 2011, The British journal of dermatology.

[28]  P. Shewry,et al.  Suppression of gliadins results in altered protein body morphology in wheat. , 2011, Journal of experimental botany.

[29]  L. Gilissen,et al.  Dough quality of bread wheat lacking α-gliadins with celiac disease epitopes and addition of celiac-safe avenins to improve dough quality , 2011 .

[30]  F. Dupont,et al.  Deciphering the complexities of the wheat flour proteome using quantitative two-dimensional electrophoresis, three proteases and tandem mass spectrometry , 2011, Proteome Science.

[31]  S. Altenbach,et al.  Transformation of the US bread wheat ‘Butte 86’ and silencing of omega-5 gliadin genes , 2011, GM crops.

[32]  J. Drijfhout,et al.  A Universal Approach to Eliminate Antigenic Properties of Alpha-Gliadin Peptides in Celiac Disease , 2010, PloS one.

[33]  D. Lafiandra,et al.  Production of novel allelic variation for genes involved in starch biosynthesis through mutagenesis , 2010, Molecular Breeding.

[34]  D. Balduzzi,et al.  Are we not over-estimating the prevalence of coeliac disease in the general population? , 2010, Annals of medicine.

[35]  Chen Hongbing,et al.  In search of tetraploid wheat accessions reduced in celiac disease-related gluten epitopes. , 2010, Molecular bioSystems.

[36]  L. Sollid,et al.  Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference , 2010, Proceedings of the National Academy of Sciences.

[37]  M. Smulders,et al.  Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease , 2010, Theoretical and Applied Genetics.

[38]  D. Jewell,et al.  Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease , 2010, Science Translational Medicine.

[39]  J. Dubcovsky,et al.  A modified TILLING approach to detect induced mutations in tetraploid and hexaploid wheat , 2009, BMC Plant Biology.

[40]  P. Qi,et al.  The γ-gliadin multigene family in common wheat (Triticum aestivum) and its closely related species , 2009, BMC Genomics.

[41]  Y. Gu,et al.  The wheat ω-gliadin genes: structure and EST analysis , 2009, Functional & Integrative Genomics.

[42]  C. Schuit,et al.  Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines , 2009, BMC Plant Biology.

[43]  J. Sidney,et al.  Intestinal T Cell Responses to Gluten Peptides Are Largely Heterogeneous: Implications for a Peptide-Based Therapy in Celiac Disease1 , 2009, The Journal of Immunology.

[44]  Pat Baird,et al.  Health benefits of dietary fiber. , 2009, Nutrition reviews.

[45]  L. Gilissen,et al.  Tetraploid and hexaploid wheat varieties reveal large differences in expression of alpha-gliadins from homoeologous Gli-2 loci , 2009, BMC Genomics.

[46]  P. Shewry,et al.  Allergens to wheat and related cereals , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[47]  P. Shewry,et al.  Silencing of γ-gliadins by RNA interference (RNAi) in bread wheat , 2008 .

[48]  J. Buttriss,et al.  Dietary fibre and health: an overview , 2008 .

[49]  D. Topping.  Cereal complex carbohydrates and their contribution to human health , 2007 .

[50]  J. Dvorak,et al.  Erratum: Genome plasticity a key factor in the success of polyploid wheat under domestication (Science (1862)) , 2007 .

[51]  T. B. Osborne.  The Vegetable Proteins , 2007, Nature.

[52]  A. Fasano,et al.  Detection of Celiac Disease in Primary Care: A Multicenter Case-Finding Study in North America , 2007, The American Journal of Gastroenterology.

[53]  A. Buchman.  Second Annual Snowbird Conference on Clinical Management of Inflammatory Bowel Diseases and Intestinal Failure March 9–12, 2006 , 2007, The American Journal of Gastroenterology.

[54]  M. Mitreva,et al.  Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes , 2006, BMC Genomics.

[55]  D. Jewell,et al.  Antagonists and non-toxic variants of the dominant wheat gliadin T cell epitope in coeliac disease , 2005, Gut.

[56]  J. Drijfhout,et al.  Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. , 2005, Gastroenterology.

[57]  M. Ráki,et al.  Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease. , 2005, Gastroenterology.

[58]  S. Fuerstenberg,et al.  A reverse genetic, nontransgenic approach to wheat crop improvement by TILLING , 2005, Nature Biotechnology.

[59]  A. Tatham,et al.  Identification of the IgE-binding Epitope in ω-5 Gliadin, a Major Allergen in Wheat-dependent Exercise-induced Anaphylaxis* , 2004, Journal of Biological Chemistry.

[60]  S. Henikoff,et al.  Efficient discovery of DNA polymorphisms in natural populations by Ecotilling. , 2004, The Plant journal : for cell and molecular biology.

[61]  J. Drijfhout,et al.  The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. , 2002, Gastroenterology.

[62]  S. Henikoff,et al.  Targeting induced local lesions IN genomes (TILLING) for plant functional genomics. , 2000, Plant physiology.

[63]  D. Jewell,et al.  In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope , 2000, Nature Medicine.

[64]  J. Dvorak,et al.  The wheat low-molecular-weight glutenin genes: characterization of six new genes and progress in understanding gene family structure , 1998, Theoretical and Applied Genetics.

[65]  O. Anderson,et al.  The α-gliadin gene family. II. DNA and protein sequence variation, subfamily structure, and origins of pseudogenes , 1997, Theoretical and Applied Genetics.

[66]  G. Corazza,et al.  Wheat deficient in gliadins: promising tool for treatment of coeliac disease. , 1995, Gut.

[67]  P. Shewry,et al.  Characterization and organization of gene families at the Gli-1 loci of bread and durum wheats by restriction fragment analysis , 1991, Theoretical and Applied Genetics.

[68]  P. Shewry,et al.  The classification and nomenclature of wheat gluten proteins: A reassessment , 1986 .

[69]  P. Ciclitira,et al.  Clinical Testing in Coeliac Patients of Bread Made from Wheats Deficient in Some α-Gliadins , 1980 .

[70]  P. Ciclitira,et al.  CLINICAL TESTING OF BREAD MADE FROM NULLISOMIC 6A WHEATS IN CŒLIAC PATIENTS , 1980, The Lancet.

[71]  D. Kasarda,et al.  Nullisonmic‐Tetrasomic Wheat for Agronomic and Nutritional Studies 1 , 1978 .

[72]  D. Kasarda,et al.  Relationship of gliadin protein components to chromosomes in hexaploid wheats (Triticum aestivum L.). , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[73]  W. Williams.  Evolution of Crop Plants , 1965, Nature.

[74]  Tariq Mahmood,et al.  Genetic Diversity for Wheat Improvement as a Conduit to Food Security , 2013 .

[75]  D. Noto,et al.  Searching for wheat plants with low toxicity in celiac disease: Between direct toxicity and immunologic activation. , 2011, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[76]  J. Jenkins,et al.  Wheat grain proteins. , 2009 .

[77]  C. Sparks,et al.  Biolistics transformation of wheat. , 2009, Methods in molecular biology.

[78]  Huixia Wu,et al.  Agrobacterium-mediated transformation of bread and durum wheat using freshly isolated immature embryos. , 2009, Methods in molecular biology.

[79]  Mindi Schneider.  "We are Hungry!" A Summary Report of Food Riots, Government Responses, and States of Democracy in 2008 , 2008 .

[80]  P. Ng,et al.  Characterization of wheat with strongly reduced α-gliadin content. , 2007 .

[81]  P. Ng,et al.  Silencing the α-gliadins in hexaploid bread wheat. , 2007 .

[82]  E. Abdel‐Aal,et al.  Specialty grains for food and feed. , 2004 .

[83]  P. Shewry,et al.  Genetics of wheat gluten proteins. , 2003, Advances in genetics.

[84]  P. Shewry,et al.  The high molecular weight subunits of wheat glutenin and their role in determining wheat processing properties. , 2003, Advances in food and nutrition research.

[85]  P. Shewry,et al.  The Prolamins of the Triticeae , 1999 .

[86]  P. I. Payne.  Genetics of Wheat Storage Proteins and the Effect of Allelic Variation on Bread-Making Quality , 1987 .