Local stability of the nerve impulse

Abstract Some general theory of nerve impulse stability is reviewed and is applied to the Hodgkin-Huxley equations. It is seen that the transition behavior of certain uniformly propagated waves with a velocity close to the velocity of an impulse has important implications with regard to stability. Numerical estimates of some of the principal objects in the stability theory for the Hodgkin-Huxley equations are given.

[1]  D. Aronson,et al.  Nonlinear diffusion in population genetics, combustion, and nerve pulse propagation , 1975 .

[2]  J. Evans,et al.  Solutions to axon equations. , 1970, Biophysical journal.

[3]  H. McKean Nagumo's equation , 1970 .

[4]  H. A. Antosiewicz,et al.  Automatic Computation of Nerve Excitation , 1955 .

[5]  S. P. Hastings,et al.  On travelling wave solutions of the Hodgkin-Huxley equations , 1976 .

[6]  John Evans,et al.  Nerve Axon Equations: II Stability at Rest , 1972 .

[7]  A. Huxley ION MOVEMENTS DURING NERVE ACTIVITY , 1959, Annals of the New York Academy of Sciences.

[8]  R. FitzHugh Impulses and Physiological States in Theoretical Models of Nerve Membrane. , 1961, Biophysical journal.

[9]  J. Hearon Applications of Results from Linear Kinetics to the Hodgkin-Huxley Equations. , 1964, Biophysical journal.

[10]  J. Rinzel Spatial stability of traveling wave solutions of a nerve conduction equation. , 1975, Biophysical journal.

[11]  E. Coddington,et al.  Theory of Ordinary Differential Equations , 1955 .

[12]  Joel Smoller,et al.  Qualitative theory of the FitzHugh-Nagumo equations , 1978 .

[13]  A. Hodgkin,et al.  A quantitative description of membrane current and its application to conduction and excitation in nerve , 1952, The Journal of physiology.

[14]  Tosio Kato Perturbation theory for linear operators , 1966 .

[15]  John Evans Nerve Axon Equations: III Stability of the Nerve Impulse , 1972 .

[16]  G. Carpenter A geometric approach to singular perturbation problems with applications to nerve impulse equations , 1977 .

[17]  S. Yoshizawa,et al.  An Active Pulse Transmission Line Simulating Nerve Axon , 1962, Proceedings of the IRE.

[18]  J Rinzel,et al.  Traveling wave solutions of a nerve conduction equation. , 1973, Biophysical journal.

[19]  A. Hodgkin The conduction of the nervous impulse , 1964 .

[20]  R. G. Casten,et al.  Perturbation analysis of an approximation to the Hodgkin-Huxley theory , 1975 .

[21]  J. Greenberg A NOTE ON THE NAGUMO EQUATION , 1973 .

[22]  J. Cooley,et al.  Digital computer solutions for excitation and propagation of the nerve impulse. , 1966, Biophysical journal.

[23]  R. FitzHugh,et al.  Automatic Computation of Nerve Excitation—Detailed Corrections and Additions , 1959 .