Midline cerebral malformations and schizophrenia.

To investigate a possible association of midline cerebral malformations with psychotic disorders, MRI and CT scans were blindly evaluated for 52 patients with schizophrenia, 9 with schizoaffective disease, and 79 consecutive nonpsychotic control subjects. Midline abnormalities were present in 10 of 61 patients (16.4%) versus 4 of 79 control subjects (5.1%; P < 0.05, chi-square). Of 52 schizophrenic patients, 8 had abnormalities of the septum pellucidum (SP): 5 had cavum vergae (CaV), 2 had cavum septum pellucidum (CaSP), and 1 had agenesis of the corpus callosum and SP. Of 9 schizoaffective patients, 2 had SP abnormalities: 1 CaV and 1 CaSP. Abnormalities of the SP, especially CaV, were significantly more frequent in women than in men (P < 0.02, chi-square).

[1]  M. LeMay,et al.  Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. , 1992, The New England journal of medicine.

[2]  D. Weinberger,et al.  Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins. , 1992, The American journal of psychiatry.

[3]  J. Sweeney,et al.  Clinical Correlates of Cerebral Ventricular Enlargement in Schizophrenia: Further Evidence for Frontal Lobe Disease , 1992, The Journal of nervous and mental disease.

[4]  I. Mcmanus,et al.  Ventricular Enlargement in Schizophrenia , 1992, British Journal of Psychiatry.

[5]  J. Lieberman,et al.  Abnormalities of the septum pellucidum on MR scans in first-episode schizophrenic patients. , 1992, AJNR. American journal of neuroradiology.

[6]  James C. Ehrhardt,et al.  Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study , 1992, Biological Psychiatry.

[7]  F. Benes,et al.  Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. , 1991, Archives of general psychiatry.

[8]  D L Braff,et al.  Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. , 1991, Archives of general psychiatry.

[9]  M. George,et al.  Neuroactivation and Neuroimaging with SPET , 1991, Springer London.

[10]  B T Hyman,et al.  Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. , 1991, Archives of general psychiatry.

[11]  A. Scheibel,et al.  Hippocampal pyramidal cell disarray in schizophrenia as a bilateral phenomenon. , 1991, Archives of general psychiatry.

[12]  S. Heckers,et al.  Cortex, white matter, and basal ganglia in schizophrenia: A volumetric postmortem study , 1991, Biological Psychiatry.

[13]  B. Pakkenberg,et al.  Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. , 1990, Archives of general psychiatry.

[14]  N C Andreasen,et al.  Developmental abnormalities of the corpus callosum in schizophrenia. , 1990, Archives of neurology.

[15]  D. Jeste,et al.  Hippocampal pathologic findings in schizophrenia. A morphometric study. , 1989, Archives of general psychiatry.

[16]  J. Kleinman,et al.  A quantitative investigation of hippocampal pyramidal cell size, shape, and variability of orientation in schizophrenia. , 1989, Archives of general psychiatry.

[17]  H. Kaiya,et al.  Midsagittal cortical pathomorphology of schizophrenia: A magnetic resonance imaging study , 1989, Psychiatry Research.

[18]  M. Trimble,et al.  Self-injurious behaviour and the Gilles de la Tourette syndrome: a clinical study and review of the literature , 1989, Psychological Medicine.

[19]  H. Natter,et al.  Incidence of cavum septum pellucidum in adults , 1989, Neurology.

[20]  J. Kelsoe,et al.  Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. , 1989, The American journal of psychiatry.

[21]  R. Heath,et al.  Antiseptal brain antibody in IgG of schizophrenic patients , 1989, Biological Psychiatry.

[22]  D. Norman,et al.  Absence of the septum pellucidum: a useful sign in the diagnosis of congenital brain malformations. , 1988, AJR. American journal of roentgenology.

[23]  B. Bogerts,et al.  Limbic pathology in schizophrenia: The entorhinal region—a morphometric study , 1988, Biological Psychiatry.

[24]  R. Shelton,et al.  Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect. , 1988, The American journal of psychiatry.

[25]  G. Pearlson,et al.  Increased ventricle-to-brain ratio in late-onset schizophrenia. , 1987, The American journal of psychiatry.

[26]  F. Benes,et al.  An analysis of the arrangement of neurons in the cingulate cortex of schizophrenic patients. , 1987, Archives of general psychiatry.

[27]  D. Kido,et al.  Cavum vergae. Association with neurologic abnormality and diagnosis by magnetic resonance imaging. , 1986, Archives of neurology.

[28]  R. Mathew,et al.  A study of the septum pellucidum and corpus callosum in schizophrenia with MR imaging , 1985, Acta psychiatrica Scandinavica.

[29]  M. Reveley,et al.  CT Scans in Schizophrenia , 1985, British Journal of Psychiatry.

[30]  S. Lewis,et al.  Clinical correlates of septum pellucidum cavities: an unusual association with psychosis , 1985, Psychological Medicine.

[31]  H. Nasrallah,et al.  Corpus Callosum Thickness in Chronic Schizophrenia , 1983, British Journal of Psychiatry.

[32]  J. Stevens,et al.  Neuropathology of schizophrenia. , 1982, Archives of general psychiatry.

[33]  D. Weinberger,et al.  Lateral cerebral ventricular enlargement in chronic schizophrenia. , 1979, Archives of general psychiatry.

[34]  R. Heath,et al.  Focal electroencephalographic changes induced by anti-septal antibodies. , 1974, Biological Psychiatry.

[35]  G. Pearlson,et al.  Sylvian fissure size in schizophrenia measured with the magnetic resonance imaging rating protocol of the Consortium to Establish a Registry for Alzheimer's Disease. , 1992, The American journal of psychiatry.

[36]  Trimble Mr.  Can schizophrenia be localized , 1991 .

[37]  J. Ehrhardt,et al.  Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. , 1990, Archives of general psychiatry.

[38]  G D Pearlson,et al.  Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. , 1990, The American journal of psychiatry.

[39]  Paul D. MacLean,et al.  An Explanation of Behavior. (Book Reviews: The Triune Brain in Evolution. Role in Paleocerebral Functions.) , 1990 .

[40]  J. Luauté,et al.  Abnormalities of the septum pellucidum in schizophrenia. , 1990, The Journal of neuropsychiatry and clinical neurosciences.

[41]  C. Kellner,et al.  Abnormalities of the septum pellucidum in schizophrenia. , 1989, The Journal of neuropsychiatry and clinical neurosciences.

[42]  R Jagoe,et al.  Postmortem evidence of structural brain changes in schizophrenia. Differences in brain weight, temporal horn area, and parahippocampal gyrus compared with affective disorder. , 1986, Archives of general psychiatry.