A polymer-based packaging platform for creating hybrid microfluidic systems is presented. Polydimethylsiloxane (PDMS) is cast into an acrylic mold frame with suspended elements that are removed after curing to form chip cavities, inlet and outlet ports, microchannels, and reservoirs. The packaging approach enables the integration of off-the-shelf components such as pumps and valves with glass microfluidic devices, electronic chips, sample reservoirs, and flow channels. A particle pre-concentration module with a glass capture chip and integrated micropump is shown as an example. A pneumatically driven microfluidic pumping module is also shown. Custom microfluidic interconnects for interfacing to micro-scale fluidic systems are presented. The connectors are capable of withstanding more than 1000 psi and allow microdevices to be rapidly connected to macroscopic devices and systems, without the use of tools.
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