How does the kidney filter plasma?

The kidneys filter the plasma in special filtration units-glomeruli-and thereby excrete low-molecular-weight waste products into the urine. The mechanisms of glomerular filtration have been a matter of controversy for several decades, but recent data have revealed new details about the molecular nature of the filter and have demonstrated a central role for the podocyte slit diaphragm in the filtration process.

[1]  K. Tryggvason,et al.  Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm. , 1999, Journal of the American Society of Nephrology : JASN.

[2]  L Peltonen,et al.  Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. , 1998, Molecular cell.

[3]  T. B. Huber,et al.  NEPH1 defines a novel family of podocin‐interacting proteins , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  S. Furuta,et al.  Three-dimensional study of glomerular slit diaphragm by the quick-freezing and deep-etching replica method. , 1990, European journal of cell biology.

[5]  H. Rennke,et al.  Glomerular permeability: in vivo tracer studies with polyanionic and polycationic ferritins. , 1977, Kidney international.

[6]  J. Sanes,et al.  The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1. , 1995, Nature genetics.

[7]  K. Tryggvason,et al.  Nephrin is specifically located at the slit diaphragm of glomerular podocytes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[8]  S. Rennard,et al.  Isolation of a heparan sulfate-containing proteoglycan from basement membrane. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[9]  B. Haraldsson,et al.  Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier. , 2004, News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society.

[10]  M. Karnovsky,et al.  The structural basis of glomerular filtration. , 1972, Advances in nephrology from the Necker Hospital.

[11]  T. Benzing,et al.  Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. , 2003, Journal of the American Society of Nephrology : JASN.

[12]  T. Oegema,et al.  Heparan sulfate--rich anionic sites in the human glomerular basement membrane. Decreased concentration in congenital nephrotic syndrome. , 1983, The New England journal of medicine.

[13]  M. Ruegg,et al.  Agrin Is a Major Heparan Sulfate Proteoglycan in the Human Glomerular Basement Membrane , 1998, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[14]  P. Yurchenco,et al.  Basal lamina assembly. , 1994, Current opinion in cell biology.

[15]  B. Haraldsson,et al.  Glomerular charge selectivity for horseradish peroxidase and albumin at low and normal ionic strengths. , 1998, Acta physiologica Scandinavica.

[16]  Tsutomu Inoue,et al.  FAT is a component of glomerular slit diaphragms. , 2001, Kidney international.

[17]  K. Tryggvason,et al.  Alport's syndrome, Goodpasture's syndrome, and type IV collagen. , 2003, The New England journal of medicine.

[18]  Eetu Mäkelä,et al.  Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography. , 2004, The Journal of clinical investigation.

[19]  Y. Kanwar,et al.  Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. , 2003, The Journal of clinical investigation.

[20]  O. Smithies Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[21]  L. Chodosh,et al.  Precocious Mammary Gland Development in P-Cadherin–deficient Mice , 1997, The Journal of cell biology.

[22]  B. Duling,et al.  Permeation of the luminal capillary glycocalyx is determined by hyaluronan. , 1999, American journal of physiology. Heart and circulatory physiology.

[23]  K. Tryggvason,et al.  The murine nephrin gene is specifically expressed in kidney, brain and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. , 2001, Human molecular genetics.

[24]  N. Kashihara,et al.  Current status of the structural and functional basis of glomerular filtration and proteinuria. , 1991, Seminars in nephrology.

[25]  M. Saleem,et al.  Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. , 2001, The Journal of clinical investigation.

[26]  G. Remuzzi,et al.  Abnormal protein traffic through the glomerular barrier induces proximal tubular cell dysfunction and causes renal injury. , 1995, Current opinion in nephrology and hypertension.

[27]  P. Avasthi,et al.  Glomerular endothelial glycocalyx. , 1988, Contributions to nephrology.

[28]  M. Farquhar,et al.  Anionic sites in the glomerular basement membrane. In vivo and in vitro localization to the laminae rarae by cationic probes , 1979, The Journal of cell biology.

[29]  Michael Loran Dustin,et al.  Congenital nephrotic syndrome in mice lacking CD2-associated protein. , 1999, Science.

[30]  Karnovsky Mj,et al.  The structural basis of glomerular filtration. , 1972 .

[31]  K. Sigmundsson,et al.  Nephrin promotes cell-cell adhesion through homophilic interactions. , 2003, The American journal of pathology.

[32]  B. Schermer,et al.  The Carboxyl Terminus of Neph Family Members Binds to the PDZ Domain Protein Zonula Occludens-1* , 2003, The Journal of Biological Chemistry.

[33]  B. Olsen,et al.  Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney , 2003, The EMBO journal.

[34]  M. Karnovsky,et al.  POROUS SUBSTRUCTURE OF THE GLOMERULAR SLIT DIAPHRAGM IN THE RAT AND MOUSE , 1974, The Journal of cell biology.

[35]  A. Groffen,et al.  Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane. , 1999, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[36]  M. Farquhar,et al.  Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans (heparan sulfate) by enzyme digestion , 1980, The Journal of cell biology.

[37]  James M. Anderson,et al.  The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium , 1990, The Journal of cell biology.

[38]  R. Ramirez-Solis,et al.  Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN , 2001, Molecular and Cellular Biology.

[39]  K. Tryggvason,et al.  Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. , 1993, The Journal of biological chemistry.

[40]  R. Cotran,et al.  Role of molecular charge in glomerular permeability. Tracer studies with cationized ferritins , 1975, The Journal of cell biology.

[41]  T. Benzing,et al.  Interaction with Podocin Facilitates Nephrin Signaling* , 2001, The Journal of Biological Chemistry.

[42]  J. Sanes,et al.  The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform , 1997, The Journal of cell biology.

[43]  M. Skolnick,et al.  Identification of mutations in the COL4A5 collagen gene in Alport syndrome. , 1990, Science.

[44]  Corinne Antignac,et al.  NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome , 2000, Nature Genetics.

[45]  Sara Sandin,et al.  Structure and flexibility of individual immunoglobulin G molecules in solution. , 2004, Structure.

[46]  M. Kretzler,et al.  The glomerular slit diaphragm is a modified adherens junction. , 2000, Journal of the American Society of Nephrology : JASN.

[47]  C. ffrench-Constant,et al.  Mice Lacking the Giant Protocadherin mFAT1 Exhibit Renal Slit Junction Abnormalities and a Partially Penetrant Cyclopia and Anophthalmia Phenotype , 2003, Molecular and Cellular Biology.

[48]  R. Cotran,et al.  Tracer Studies with Cationized Ferritins , 1975 .