Genetic validation of aldolase and glyceraldehyde-3-phosphate dehydrogenase as drug targets in Trypanosoma brucei.
暂无分享,去创建一个
[1] C. Clayton,et al. Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei. , 1997, Molecular and biochemical parasitology.
[2] J. Chambers,et al. The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. , 2008, Molecular and biochemical parasitology.
[3] Zefeng Wang,et al. The Adenosine Analog Tubercidin Inhibits Glycolysis in Trypanosoma brucei as Revealed by an RNA Interference Library* , 2003, Journal of Biological Chemistry.
[4] Glaucius Oliva,et al. Structural Basis for Selective Inhibition of Trypanosomatid Glyceraldehyde-3-Phosphate Dehydrogenase: Molecular Docking and 3D QSAR Studies , 2008, J. Chem. Inf. Model..
[5] J. F. Ryley,et al. Studies on the metabolism of the Protozoa. 7. Comparative carbohydrate metabolism of eleven species of trypanosome. , 1956, The Biochemical journal.
[6] Andreas Seyfang,et al. Specificity of glucose transport in Trypanosoma brucei , 1991 .
[7] Barbara M. Bakker,et al. Glycolysis in Bloodstream Form Trypanosoma brucei Can Be Understood in Terms of the Kinetics of the Glycolytic Enzymes* , 1997, The Journal of Biological Chemistry.
[8] M. Walkinshaw,et al. Design, synthesis and trypanocidal activity of lead compounds based on inhibitors of parasite glycolysis. , 2008, Bioorganic & medicinal chemistry.
[9] C L Verlinde,et al. Glycolysis as a target for the design of new anti-trypanosome drugs. , 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[10] L. Azéma,et al. Cell permeation of a Trypanosoma brucei aldolase inhibitor: evaluation of different enzyme-labile phosphate protecting groups. , 2006, Bioorganic & medicinal chemistry letters.
[11] F. Opperdoes,et al. Glycolytic enzymes of Trypanosoma brucei. Simultaneous purification, intraglycosomal concentrations and physical properties. , 1986, European journal of biochemistry.
[12] N. Chabot,et al. Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei. , 2006, Journal of medicinal chemistry.
[13] F. Opperdoes,et al. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[14] Barbara M. Bakker,et al. Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei. , 2001, The Biochemical journal.
[15] F. Opperdoes,et al. The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. , 1995, The Biochemical journal.
[16] Solomon Nwaka,et al. Innovative lead discovery strategies for tropical diseases , 2006, Nature Reviews Drug Discovery.
[17] M. Gelb,et al. A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. , 2001, Bioorganic & medicinal chemistry letters.
[18] F. Opperdoes,et al. Localization of nine glycolytic enzymes in a microbody‐like organelle in Trypanosoma brucei: The glycosome , 1977, FEBS letters.
[19] F. Opperdoes,et al. Enzymes of carbohydrate metabolism as potential drug targets. , 2001, International journal for parasitology.
[20] F. Opperdoes,et al. Simultaneous purification of hexokinase, class-I fructose-bisphosphate aldolase, triosephosphate isomerase and phosphoglycerate kinase from Trypanosoma brucei. , 1984, European journal of biochemistry.
[21] Barbara M. Bakker,et al. Experimental and in Silico Analyses of Glycolytic Flux Control in Bloodstream Form Trypanosoma brucei* , 2005, Journal of Biological Chemistry.