Prolonged antigen presentation by immune complex–binding dendritic cells programs the proliferative capacity of memory CD8 T cells

Antibodies can regulate the quality and functionality of a subset of antiviral CD8+ T cell memory responses to influenza by promoting sustained DC antigen presentation during the contraction phase of primary responses.

[1]  E. Fiebiger,et al.  Cross-presentation of IgG-containing immune complexes , 2013, Cellular and Molecular Life Sciences.

[2]  D. Gray,et al.  B cells: programmers of CD4 T cell responses. , 2012, Infectious disorders drug targets.

[3]  M. Bevan,et al.  TCR signaling requirements for activating T cells and for generating memory , 2012, Cellular and Molecular Life Sciences.

[4]  J. Borst,et al.  The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27–CD70 interactions , 2012, Nature Communications.

[5]  Ramon Arens,et al.  Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells , 2011, Nature Immunology.

[6]  D. Dolfi,et al.  Dendritic Cells and CD28 Costimulation Are Required To Sustain Virus-Specific CD8+ T Cell Responses during the Effector Phase In Vivo , 2011, The Journal of Immunology.

[7]  T. Randall,et al.  Contributions of Antinucleoprotein IgG to Heterosubtypic Immunity against Influenza Virus , 2011, The Journal of Immunology.

[8]  Ravi S. Misra,et al.  Regulation of Antinucleoprotein IgG by Systemic Vaccination and Its Effect on Influenza Virus Clearance , 2011, Journal of Virology.

[9]  T. Coffman,et al.  B Lymphocytes Differentially Influence Acute and Chronic Allograft Rejection in Mice , 2011, The Journal of Immunology.

[10]  Taeg S. Kim,et al.  Antiviral CD8+ T cell effector activities in situ are regulated by target cell type , 2011, The Journal of experimental medicine.

[11]  J. Leignadier,et al.  Epitope Density Influences CD8+ Memory T Cell Differentiation , 2010, PloS one.

[12]  Taeg S. Kim,et al.  Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection , 2010, The Journal of experimental medicine.

[13]  Ramon Arens,et al.  Plasticity in programming of effector and memory CD8+ T‐cell formation , 2010, Immunological reviews.

[14]  T. Tedder,et al.  B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice , 2010, The Journal of Immunology.

[15]  T. Randall,et al.  Effector and regulatory B cells: modulators of CD4+ T cell immunity , 2010, Nature Reviews Immunology.

[16]  M. Bevan,et al.  Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. , 2010, Immunity.

[17]  T. Randall,et al.  Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza , 2010, Nature Immunology.

[18]  L. Lefrançois,et al.  Memory CD8+ T cell differentiation , 2010, Annals of the New York Academy of Sciences.

[19]  J. Harty,et al.  A Default Pathway of Memory CD8 T Cell Differentiation after Dendritic Cell Immunization Is Deflected by Encounter with Inflammatory Cytokines during Antigen-Driven Proliferation1 , 2009, The Journal of Immunology.

[20]  R. Ahmed,et al.  Requirement of B Cells for Generating CD4+ T Cell Memory1 , 2009, The Journal of Immunology.

[21]  Dietmar Zehn,et al.  Complete but curtailed T cell response to very low affinity antigen , 2009, Nature.

[22]  T. Randall,et al.  A Novel Role for Non-Neutralizing Antibodies against Nucleoprotein in Facilitating Resistance to Influenza Virus1 , 2008, The Journal of Immunology.

[23]  K. Legge,et al.  Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs , 2008, The Journal of experimental medicine.

[24]  M. Kehry,et al.  Suppression of Proteoglycan-Induced Arthritis by Anti-CD20 B Cell Depletion Therapy Is Mediated by Reduction in Autoantibodies and CD4+ T Cell Reactivity1 , 2008, The Journal of Immunology.

[25]  F. Wong,et al.  B-Cells Promote Intra-Islet CD8+ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes , 2008, Diabetes.

[26]  D. Dolfi,et al.  Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8+ T Cells1 , 2008, The Journal of Immunology.

[27]  A. Chakraborty,et al.  T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation , 2008, Nature Immunology.

[28]  John T. Harty,et al.  Shaping and reshaping CD8+ T-cell memory , 2008, Nature Reviews Immunology.

[29]  Ravi S. Misra,et al.  B Cells Promote Resistance to Heterosubtypic Strains of Influenza via Multiple Mechanisms1 , 2008, The Journal of Immunology.

[30]  R. Melamed,et al.  Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation , 2007, Proceedings of the National Academy of Sciences.

[31]  D. Turner,et al.  Persistent Antigen Presentation after Acute Vesicular Stomatitis Virus Infection , 2006, Journal of Virology.

[32]  M. Bevan,et al.  Duration of the initial TCR stimulus controls the magnitude but not functionality of the CD8+ T cell response , 2006, The Journal of experimental medicine.

[33]  A. Tyznik,et al.  Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells , 2006, Nature.

[34]  Michael Y. Gerner,et al.  Signals required for programming effector and memory development by CD8+ T cells , 2006, Immunological reviews.

[35]  D. Turner,et al.  Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. , 2006, Immunity.

[36]  R. Webby,et al.  A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Deborah M. Brown,et al.  Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation , 2005, The Journal of experimental medicine.

[38]  K. Mozdzanowska,et al.  Roles of CD4+ T-Cell-Independent and -Dependent Antibody Responses in the Control of Influenza Virus Infection: Evidence for Noncognate CD4+ T-Cell Activities That Enhance the Therapeutic Activity of Antiviral Antibodies , 2005, Journal of Virology.

[39]  Quynh-Mai Pham,et al.  Dendritic cells maximize the memory CD8 T cell response to infection. , 2005, Immunity.

[40]  J. Harty,et al.  CD8+ T cell contraction is controlled by early inflammation , 2004, Nature Immunology.

[41]  G. Belz,et al.  Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[42]  H. Ploegh,et al.  Control of cross‐presentation during dendritic cell maturation , 2004, European journal of immunology.

[43]  E. Wherry,et al.  Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells , 2003, Nature Immunology.

[44]  J. Christensen,et al.  Deficient CD4+ T Cell Priming and Regression of CD8+ T Cell Functionality in Virus-Infected Mice Lacking a Normal B Cell Compartment 1 , 2003, The Journal of Immunology.

[45]  P. Doherty,et al.  Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus Infections , 2003, The Journal of experimental medicine.

[46]  R. Ahmed,et al.  A Specific Role for B Cells in the Generation of CD8 T Cell Memory by Recombinant Listeria monocytogenes 1 , 2003, The Journal of Immunology.

[47]  J. Christensen,et al.  High numbers of IL-2-producing CD8+ T cells during viral infection: correlation with stable memory development. , 2002, The Journal of general virology.

[48]  Steffen Jung,et al.  In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. , 2002, Immunity.

[49]  E. Wherry,et al.  Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells , 2002, The Journal of experimental medicine.

[50]  L. Lefrançois,et al.  Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells1 , 2002, The Journal of Immunology.

[51]  M. Castrucci,et al.  The Role of Antigen in the Localization of Naive, Acutely Activated, and Memory CD8+ T Cells to the Lung During Influenza Pneumonia1 , 2001, The Journal of Immunology.

[52]  S. Stohlman,et al.  Impaired T Cell Immunity in B Cell-Deficient Mice Following Viral Central Nervous System Infection1 , 2001, The Journal of Immunology.

[53]  F. Sallusto,et al.  Antigen decoding by T lymphocytes: from synapses to fate determination , 2001, Nature Immunology.

[54]  Susan M. Kaech,et al.  Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells , 2001, Nature Immunology.

[55]  Stephen P. Schoenberger,et al.  Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation , 2001, Nature Immunology.

[56]  T. Schumacher,et al.  CD27 is required for generation and long-term maintenance of T cell immunity , 2000, Nature Immunology.

[57]  T. Honjo,et al.  Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme , 2000, Cell.

[58]  P. Doherty,et al.  Contemporary Analysis of MHC-Related Immunodominance Hierarchies in the CD8+ T Cell Response to Influenza A Viruses1 , 2000, The Journal of Immunology.

[59]  S. Amigorena,et al.  Fc receptor signaling and trafficking: a connection for antigen processing , 1999, Immunological reviews.

[60]  P. Ricciardi-Castagnoli,et al.  Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization , 1999, The Journal of experimental medicine.

[61]  M. V. von Herrath,et al.  Evidence for an Underlying CD4 Helper and CD8 T-Cell Defect in B-Cell-Deficient Mice: Failure To Clear Persistent Virus Infection after Adoptive Immunotherapy with Virus-Specific Memory Cells from μMT/μMT Mice , 1998, Journal of Virology.

[62]  P. Doherty,et al.  Quantitative analysis of the influenza virus-specific CD4+ T cell memory in the absence of B cells and Ig. , 1996, Journal of immunology.

[63]  P. Matzinger,et al.  Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells , 1996, The Journal of experimental medicine.

[64]  R. Ahmed,et al.  CD8 T cell memory in B cell-deficient mice , 1996, The Journal of experimental medicine.

[65]  J. Ravetch,et al.  FcR γ chain deletion results in pleiotrophic effector cell defects , 1994, Cell.

[66]  T. Randall,et al.  Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8(+) T cell responses to influenza. , 2010, Nature immunology.

[67]  J. Ravetch,et al.  Fcγ receptors as regulators of immune responses , 2008, Nature Reviews Immunology.

[68]  Laurence Zitvogel,et al.  Antigen presentation and T cell stimulation by dendritic cells. , 2002, Annual review of immunology.

[69]  W. Gerhard The role of the antibody response in influenza virus infection. , 2001, Current topics in microbiology and immunology.