A case of macrosomia and macroglossia, likely Beckwith‐Wiedemann syndrome from 1628

Latin text: Caeterum in anni 1628. Principio hic Romae amico meo puerulus natus est maxime carnusus, optimeque efformatus, & in summa crassitudine alios vel crassiusculus puerulos non parum excedens. Huic lingua extra os prominebat tribus saltem digitis, quae etiam craffiuscula, & latiuscula erat, quam conveniret, at cum illam exerebat, mirum erat quantopere extra oris septa promineret. Lac tamen optime sugebat, licet papillas requireret crassiores, & longiores, si enim exiliores, brevioresque essent, nequaquam sugere poterat. Bimestre spatio annum exuperans quatuor tantum dentes ediderat, comedebat tamen, & bibebat, & verba nonnulla, prout aetatis teneritudo ferr, proferebat. Obiit non multo post, quo morbo compertum non habeo. English translation of the Latin (see Figure 1): In the beginning of the year 1628, a baby boy was born to my friend in Rome. The baby was born pudgy and large but otherwise very well formed and not exceeding other babies even moderately oversized. The baby's tongue was outside of his mouth and stood out at least by the breadth of three fingers. The tongue was also larger and wider than normal. And since he was exposing it, it was astonishing how much it would extend out of the mouth as a barrier. However, the baby was sucking milk well, although one might desire thicker and longer nipples for in fact, if the (mother's) nipples had been thinner and shorter, the baby would not have been able to suck. After the lapse of a year and two months, only four teeth came out but the baby was eating, drinking, and producing words in accordance with his young age. He died shortly after from an illness but from what disease exactly I do not know.

[1]  A. Ganguly,et al.  Characterization of the Beckwith‐Wiedemann spectrum: Diagnosis and management , 2019, American journal of medical genetics. Part C, Seminars in medical genetics.

[2]  J. Duffin Questioning medicine in seventeenth-century Rome: the consultations of Paolo Zacchia. , 2011, Canadian bulletin of medical history = Bulletin canadien d'histoire de la medecine.

[3]  K. Händel [Paolo Zacchia--the spiritual father of forensic medicine]. , 2003, Archiv fur Kriminologie.