Plasma serotonin in horses undergoing surgery for small intestinal colic.

This study compared serotonin concentrations in platelet poor plasma (PPP) from healthy horses and horses with surgical small intestinal (SI) colic, and evaluated their association with postoperative ileus, strangulation and non-survival. Plasma samples (with EDTA) from 33 horses with surgical SI colic were collected at several pre- and post-operative time points. Serotonin concentrations were determined using liquid-chromatography tandem mass spectrometry. Results were compared with those for 24 healthy control animals. The serotonin concentrations in PPP were significantly lower (P < 0.01) in pre- and post-operative samples from surgical SI colic horses compared to controls. However, no association with postoperative ileus or non-survival could be demonstrated at any time point. In this clinical study, plasma serotonin was not a suitable prognostic factor in horses with SI surgical colic.

[1]  J. G. Clavel,et al.  Cortisol, adrenocorticotropic hormone, serotonin, adrenaline and noradrenaline serum concentrations in relation to disease and stress in the horse. , 2012, Research in veterinary science.

[2]  G. Piccione,et al.  Effects of hydrocortisone and aminophylline on the aggregation of equine platelets in vitro , 2011, Journal of veterinary science.

[3]  D. Alberghina,et al.  Modulation of peripheral markers of the serotoninergic system in healthy horses. , 2011, Research in veterinary science.

[4]  J. Varga,et al.  Different Ischemic Preconditioning Regimens Affecting Preservation Injury of Intestines , 2011, European Surgical Research.

[5]  G. Piccione,et al.  Peripheral serotoninergic response to physical exercise in athletic horses , 2010, Journal of veterinary science.

[6]  C. Giannetto,et al.  Effect of diet on plasma tryptophan and serotonin in trained mares and geldings , 2010, Veterinary Record.

[7]  J. Dewulf,et al.  Risk factors for equine postoperative ileus and effectiveness of prophylactic lidocaine. , 2009, Journal of veterinary internal medicine.

[8]  J. Hauptman,et al.  Prevalence of and risk factors for postoperative ileus after small intestinal surgery in two hundred and thirty-three horses. , 2009, Veterinary surgery : VS.

[9]  B. Roth,et al.  The expanded biology of serotonin. , 2009, Annual review of medicine.

[10]  D. Tortonese,et al.  Seasonal Changes in Circadian Peripheral Plasma Concentrations of Melatonin, Serotonin, Dopamine and Cortisol in Aged Horses with Cushing’s Disease under Natural Photoperiod , 2008, Journal of neuroendocrinology.

[11]  G. R. Van de Walle,et al.  Determination of the source of increased serotonin (5-HT) concentrations in blood and peritoneal fluid of colic horses with compromised bowel. , 2008, Equine veterinary journal.

[12]  C. Marr,et al.  Platelets in equine recurrent airway obstruction. , 2007, Research in veterinary science.

[13]  J. Tack,et al.  REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders , 2007 .

[14]  P. Whorwell,et al.  Altered 5-hydroxytryptamine signaling in patients with constipation- and diarrhea-predominant irritable bowel syndrome. , 2006, Gastroenterology.

[15]  T. Mair,et al.  Survival and complication rates in 300 horses undergoing surgical treatment of colic. Part 2: Short-term complications. , 2010, Equine veterinary journal.

[16]  H. Ikeda,et al.  Platelet release of beta-thromboglobulin and platelet factor 4 and serotonin in plasma samples. , 2005, Clinical biochemistry.

[17]  B. Rush,et al.  Evaluation of plasma catecholamine and serum cortisol concentrations in horses with colic. , 2005, Journal of the American Veterinary Medical Association.

[18]  G. Piccione,et al.  Central fatigue and nycthemeral change of serum tryptophan and serotonin in the athletic horse , 2005, Journal of circadian rhythms.

[19]  Gulzar Singh,et al.  Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. , 2005, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[20]  M. Gershon.  Review article: serotonin receptors and transporters — roles in normal and abnormal gastrointestinal motility , 2004, Alimentary pharmacology & therapeutics.

[21]  M. Ryska,et al.  Serotonin levels in the small bowel mucosa as a marker of ischemic injury during small bowel preservation. , 2004, Annals of transplantation.

[22]  J. Snyder,et al.  Survey of prokinetic use in horses with gastrointestinal injury. , 2004, Veterinary surgery : VS.

[23]  L. Katz,et al.  Seasonal changes in plasma concentrations of cecum-derived amines in clinically normal ponies and ponies predisposed to laminitis. , 2003, American journal of veterinary research.

[24]  M. Crowell,et al.  The role of serotonin in the pathophysiology of irritable bowel syndrome. , 2001, The American journal of managed care.

[25]  R. Sakata,et al.  Contribution of serotonin to liver injury following canine small-intestinal ischemia and reperfusion. , 2001, The Journal of surgical research.

[26]  貝原 聡.  Serotonin as a useful parameter for cold and warm ischemic injury in small bowel transplantation , 2000 .

[27]  D. Lebelt,et al.  Physiological correlates associated with cribbing behaviour in horses: changes in thermal threshold, heart rate, plasma beta-endorphin and serotonin. , 1998, Equine veterinary journal. Supplement.

[28]  K. Ikeda,et al.  Plasma levels of 5-HT and 5-HIAA increased after intestinal ischemia/reperfusion in rats. , 1998, The Japanese journal of physiology.

[29]  S. Bailey,et al.  Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for pathogenesis of acute laminitis. , 1998, Equine veterinary journal.

[30]  S. Uemoto,et al.  Serotonin as a useful parameter for cold and warm ischemic injury in small bowel transplantation. , 1997, Transplantation.

[31]  P. Reggiani,et al.  Serotonin (5-HT): an enteroendocrine marker of reperfusion injury after liver-small bowel allotransplantation in the pig. , 1997, Transplantation proceedings.

[32]  J. Małyszko,et al.  Plasma serotonin and platelet aggregation during ischemia-reperfusion in dogs: effect of dipyridamole and coenzyme Q10. , 1996, Haemostasis.

[33]  A. Deacon,et al.  The Measurement of 5-Hydroxyindoleacetic Acid in Urine , 1994, Annals of clinical biochemistry.

[34]  K. Kaplan,et al.  Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo. , 1981, Blood.

[35]  A. Sirek,et al.  Serotonin: a review. , 1970, Canadian Medical Association journal.