Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
暂无分享,去创建一个
[1] J. Campisi,et al. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation , 2004, Journal of Cell Science.
[2] Adrian A Canutescu,et al. Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. , 2005, Developmental cell.
[3] T. Lange,et al. Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence , 2004, Current Biology.
[4] M. Mattson,et al. Cellular lifespan and senescence signaling in embryonic stem cells , 2004, Aging cell.
[5] P. Klatt,et al. Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging. , 2004, Genes & development.
[6] N. Sharpless,et al. Ink4a/Arf expression is a biomarker of aging. , 2004, The Journal of clinical investigation.
[7] Jichun Chen. Senescence and functional failure in hematopoietic stem cells. , 2004, Experimental hematology.
[8] G. Peters,et al. Contribution of p16(INK4a) to replicative senescence of human fibroblasts. , 2004, Experimental cell research.
[9] S. Jackson,et al. Functional links between telomeres and proteins of the DNA-damage response. , 2004, Genes & development.
[10] J. Shay,et al. Does a sentinel or a subset of short telomeres determine replicative senescence? , 2004, Molecular biology of the cell.
[11] T. Jensen,et al. Adult human mesenchymal stem cell as a target for neoplastic transformation , 2004, Oncogene.
[12] N. Barzilai,et al. The paradox of the insulin/IGF-1 signaling pathway in longevity , 2004, Mechanisms of Ageing and Development.
[13] John M Sedivy,et al. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). , 2004, Molecular cell.
[14] D. Galloway,et al. Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence , 2004, Molecular and Cellular Biology.
[15] M. Blasco,et al. Long-term molecular and cellular stability of human neural stem cell lines. , 2004, Experimental cell research.
[16] R. DePinho,et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. , 2004, Cancer cell.
[17] S. Lowe,et al. Executing Cell Senescence , 2004, Cell cycle.
[18] K. Mohammad,et al. Modulation of mammalian life span by the short isoform of p53. , 2004, Genes & development.
[19] Sean J Morrison,et al. Bmi1, stem cells, and senescence regulation. , 2004, The Journal of clinical investigation.
[20] T. Lange,et al. Significant Role for p 16 INK 4 a in p 53-Independent Telomere-Directed Senescence , 2004 .
[21] R. Weinberg,et al. When cells get stressed: an integrative view of cellular senescence. , 2004, The Journal of clinical investigation.
[22] N. Carter,et al. A DNA damage checkpoint response in telomere-initiated senescence , 2003, Nature.
[23] E. Medrano,et al. The emerging role of epigenetics in cellular and organismal aging , 2003, Experimental Gerontology.
[24] Qin M. Chen,et al. Novel mechanisms of sublethal oxidant toxicity: induction of premature senescence in human fibroblasts confers tumor promoter activity. , 2003, Experimental cell research.
[25] S. Melov,et al. Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts , 2003, Aging cell.
[26] K. Collins,et al. Telomere maintenance and disease , 2003, The Lancet.
[27] T. Lange,et al. DNA Damage Foci at Dysfunctional Telomeres , 2003, Current Biology.
[28] Masashi Narita,et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways , 2003, The EMBO journal.
[29] T. Jacks,et al. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry , 2003, Nature.
[30] S. Lowe,et al. Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence , 2003, Cell.
[31] I. Roninson,et al. Tumor cell senescence in cancer treatment. , 2003, Cancer research.
[32] C. J. Collins,et al. Involvement of the INK4a/Arf gene locus in senescence , 2003, Aging cell.
[33] S. Melov,et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts , 2003, Nature Cell Biology.
[34] Frederick Grinnell,et al. Fibroblast biology in three-dimensional collagen matrices. , 2003, Trends in cell biology.
[35] Judith Campisi,et al. Cancer and ageing: rival demons? , 2003, Nature Reviews Cancer.
[36] Manel Esteller,et al. Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. , 2003, Cancer research.
[37] Stanley N Cohen,et al. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[38] J. Hoeijmakers,et al. Aging and Genome Maintenance: Lessons from the Mouse? , 2003, Science.
[39] C. Finch,et al. Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians? , 2003, Science.
[40] S. Lowe,et al. Tumor suppression by Ink4a-Arf: progress and puzzles. , 2003, Current opinion in genetics & development.
[41] J. Campisi. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes , 2003, Experimental Gerontology.
[42] Goberdhan P Dimri,et al. Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1 , 2003, Molecular and Cellular Biology.
[43] K. Chew,et al. Methylation of p 16 INK 4 a Promoters Occurs in Vivo in Histologically Normal Human Mammary Epithelia 1 , 2003 .
[44] G. Peters,et al. Biallelic Mutations in p16INK4a Confer Resistance to Ras- and Ets-Induced Senescence in Human Diploid Fibroblasts , 2002, Molecular and Cellular Biology.
[45] P. Klatt,et al. 'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally , 2002, The EMBO journal.
[46] J. Greally,et al. Senescence and epigenetic dysregulation in cancer. , 2002, The international journal of biochemistry & cell biology.
[47] J. Campisi,et al. Cancer and aging: a model for the cancer promoting effects of the aging stroma. , 2002, The international journal of biochemistry & cell biology.
[48] P. Cole,et al. Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. , 2002, Cancer research.
[49] A. Smogorzewska,et al. Different telomere damage signaling pathways in human and mouse cells , 2002, The EMBO journal.
[50] F. McCormick,et al. The RB and p53 pathways in cancer. , 2002, Cancer cell.
[51] W. Hahn,et al. A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential Independent of Telomere Status , 2002, Molecular and Cellular Biology.
[52] J. Shay,et al. Historical claims and current interpretations of replicative aging , 2002, Nature Biotechnology.
[53] G. Peters,et al. INK4a‐deficient human diploid fibroblasts are resistant to RAS‐induced senescence , 2002, The EMBO journal.
[54] I. Roninson. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. , 2002, Cancer letters.
[55] K. Dorshkind. Multilineage development from adult bone marrow cells , 2002, Nature Immunology.
[56] Hartmut Geiger,et al. The aging of lympho-hematopoietic stem cells , 2002, Nature Immunology.
[57] D. Dunson,et al. Mutational fingerprints of aging. , 2002, Nucleic acids research.
[58] Stephen N. Jones,et al. p53 mutant mice that display early ageing-associated phenotypes , 2002, Nature.
[59] Jeffrey M. Trimarchi,et al. Transcription: Sibling rivalry in the E2F family , 2002, Nature Reviews Molecular Cell Biology.
[60] Antony M. Carr,et al. The evolution of diverse biological responses to DNA damage: insights from yeast and p53 , 2001, Nature Cell Biology.
[61] J. Campisi. Cellular senescence as a tumor-suppressor mechanism. , 2001, Trends in cell biology.
[62] O. Pereira-smith,et al. MRG15 Activates the B-myb Promoter through Formation of a Nuclear Complex with the Retinoblastoma Protein and the Novel Protein PAM14* , 2001, The Journal of Biological Chemistry.
[63] J. Campisi,et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[64] D. Carrasco,et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis , 2001, Nature.
[65] Goberdhan P Dimri,et al. Regulation of cellular senescence by p53. , 2001, European journal of biochemistry.
[66] D. Kaufman,et al. Multilineage Differentiation from Human Embryonic Stem Cell Lines , 2001, Stem cells.
[67] C. Boulanger,et al. Reducing mammary cancer risk through premature stem cell senescence , 2001, Oncogene.
[68] G. Peters,et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence , 2001, Nature.
[69] J. Shay,et al. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. , 2001, Genes & development.
[70] T. Tlsty,et al. Know thy neighbor: stromal cells can contribute oncogenic signals. , 2001, Current opinion in genetics & development.
[71] Thea D. Tlsty,et al. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes , 2001, Nature.
[72] W. Hahn,et al. Genes involved in senescence and immortalization. , 2000, Current opinion in cell biology.
[73] Steven N. Austad,et al. Why do we age? , 2000, Nature.
[74] J. Shay,et al. Hayflick, his limit, and cellular ageing , 2000, Nature Reviews Molecular Cell Biology.
[75] P. Pearson,et al. Atmospheric carbon dioxide concentrations over the past 60 million years , 2000, Nature.
[76] S. Lowe,et al. PML is induced by oncogenic ras and promotes premature senescence. , 2000, Genes & development.
[77] M J Bissell,et al. The influence of the microenvironment on the malignant phenotype. , 2000, Molecular medicine today.
[78] Pier Paolo Pandolfi,et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras , 2000, Nature.
[79] M. Serrano,et al. Tumor suppressors and oncogenes in cellular senescence☆ , 2000, Experimental Gerontology.
[80] K Watanabe,et al. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[81] R. DePinho,et al. A critical role for telomeres in suppressing and facilitating carcinogenesis. , 2000, Current opinion in genetics & development.
[82] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[83] I. Roninson,et al. Effects of p 21 Waf 1 / Cip 1 / Sdi 1 on cellular gene expression : Implications for carcinogenesis , senescence , and age-related diseases , 2000 .
[84] D. Shelton,et al. Microarray analysis of replicative senescence , 1999, Current Biology.
[85] V. Ferrans,et al. Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species* , 1999, The Journal of Biological Chemistry.
[86] Sandy Chang,et al. Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice , 1999, Cell.
[87] V. Dulic,et al. Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human Fibroblasts , 1999, Molecular and Cellular Biology.
[88] R. DePinho,et al. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus , 1999, Nature.
[89] A. Brenner,et al. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation , 1998, Oncogene.
[90] G. Peters,et al. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts , 1998, Current Biology.
[91] D. Wynford‐Thomas,et al. Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies , 1998, Molecular and Cellular Biology.
[92] Wenyi Wei,et al. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. , 1997, Science.
[93] F. Zindy,et al. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging , 1997, Oncogene.
[94] Bert Vogelstein,et al. Gatekeepers and caretakers , 1997, Nature.
[95] J. Zweier,et al. Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts , 1997, Science.
[96] S. Lowe,et al. Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.
[97] K. Kinzler,et al. Cancer-susceptibility genes. Gatekeepers and caretakers. , 1997, Nature.
[98] G. Hannon,et al. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[99] R. Tarone,et al. Frequent clones of p53-mutated keratinocytes in normal human skin. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[100] C. Reznikoff,et al. Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. , 1996, Cancer research.
[101] G. Peters,et al. Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence , 1996, Molecular and cellular biology.
[102] C Roskelley,et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[103] G. Wahl,et al. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. , 1994, Genes & development.
[104] L. Donehower,et al. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. , 1993, Oncogene.
[105] B. Howard,et al. Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts. , 1993, Oncogene.
[106] J Salvage,et al. A matter of life and death. , 1981, Nursing times.