3D Multi-Modality Medical Image Registration Using Feature Space Clustering

In this paper, 3D voxel-similarity-based (VB) registration algorithms that optimize a feature-space clustering measure are proposed to combine the segmentation and registration process. We present a unifying definition and a classification scheme for existing VB matching criteria and propose a new matching criterion: the entropy of the grey-level scatter-plot. This criterion requires no segmentation or feature extraction and no a priori knowledge of photometric model parameters. The effects of practical implementation issues concerning grey-level resampling, scatter-plot binning, parzen-windowing and resampling frequencies are discussed in detail and evaluated using real world data (CT and MRI).

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