Molecular mechanisms of the anti-cancer drug, LY2874455, in overcoming the FGFR4 mutation-based resistance
暂无分享,去创建一个
[1] A. Iwama,et al. The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma , 2021, Scientific Reports.
[2] Yongheng Chen,et al. FGFR-TKI resistance in cancer: current status and perspectives , 2021, Journal of Hematology & Oncology.
[3] S. Oesterreich,et al. FGFR4: A promising therapeutic target for breast cancer and other solid tumors. , 2020, Pharmacology & therapeutics.
[4] M. Wing,et al. Efficacy of FGFR Inhibitors and Combination Therapies for Acquired Resistance in FGFR2-Fusion Cholangiocarcinoma , 2020, Molecular Cancer Therapeutics.
[5] A. Shibata,et al. FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy , 2019, International journal of molecular sciences.
[6] Adrian V. Lee,et al. FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype , 2019, npj Breast Cancer.
[7] Sung‐Min Ahn,et al. FGF19–FGFR4 Signaling in Hepatocellular Carcinoma , 2019, Cells.
[8] S. Danopoulos,et al. FGF Signaling in Lung Development and Disease: Human Versus Mouse , 2019, Front. Genet..
[9] O. Myklebost,et al. Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma , 2019, Cells.
[10] Yong Teng,et al. Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies † , 2019, Cells.
[11] Yongheng Chen,et al. LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance. , 2018, Chemical communications.
[12] Qianming Chen,et al. Role of fibroblast growth factor receptor 4 in cancer , 2018, Cancer science.
[13] Ron O. Dror,et al. Molecular Dynamics Simulation for All , 2018, Neuron.
[14] Y. Bang,et al. A Phase 1 Study of LY2874455, an Oral Selective pan-FGFR Inhibitor, in Patients with Advanced Cancer , 2017, Targeted Oncology.
[15] G. Frühbeck,et al. The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes , 2017, Current Diabetes Reports.
[16] N. Turner,et al. Advances and challenges in targeting FGFR signalling in cancer , 2017, Nature Reviews Cancer.
[17] H. Ohta,et al. Roles of FGF Signals in Heart Development, Health, and Disease , 2016, Front. Cell Dev. Biol..
[18] Yongheng Chen,et al. Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 , 2016, PloS one.
[19] M. Katoh. FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review) , 2016, International journal of molecular medicine.
[20] Philippe Soriano,et al. Genetic insights into the mechanisms of Fgf signaling , 2016, Genes & development.
[21] R. Huber,et al. Structural analysis of the human fibroblast growth factor receptor 4 kinase. , 2014, Journal of molecular biology.
[22] N. Gray,et al. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors , 2014, ACS chemical biology.
[23] Youyong Li,et al. Assessing the performance of MM/PBSA and MM/GBSA methods. 4. Accuracies of MM/PBSA and MM/GBSA methodologies evaluated by various simulation protocols using PDBbind data set. , 2014, Physical chemistry chemical physics : PCCP.
[24] Duncan Poole,et al. Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald. , 2013, Journal of chemical theory and computation.
[25] Daniel R Roe,et al. PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data. , 2013, Journal of chemical theory and computation.
[26] Andreas W. Götz,et al. SPFP: Speed without compromise - A mixed precision model for GPU accelerated molecular dynamics simulations , 2013, Comput. Phys. Commun..
[27] L. Staudt,et al. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. , 2009, The Journal of clinical investigation.
[28] M. Korc,et al. The role of fibroblast growth factors in tumor growth. , 2009, Current cancer drug targets.
[29] Leo S. D. Caves,et al. Bio3d: An R Package , 2022 .
[30] Holger Gohlke,et al. The Amber biomolecular simulation programs , 2005, J. Comput. Chem..
[31] Junmei Wang,et al. Development and testing of a general amber force field , 2004, J. Comput. Chem..
[32] Josep Ramón Goñi,et al. Molecular dynamics simulations: advances and applications , 2015, Advances and applications in bioinformatics and chemistry : AABC.
[33] H. Prado,et al. Advances and Applications , 2010 .
[34] David A. Case,et al. On finding stationary states on large-molecule potential energy surfaces , 1985 .