Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways

[1]  C. Xian,et al.  Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia , 2017, Scientific Reports.

[2]  M. Aghaei,et al.  RhoA/ROCK pathway mediates leptin-induced uPA expression to promote cell invasion in ovarian cancer cells. , 2017, Cellular signalling.

[3]  Dana M Simmet,et al.  Rapid adaptation to microgravity in mammalian macrophage cells , 2017, Scientific Reports.

[4]  Yichao Niu,et al.  O-GlcNAcylation promotes migration and invasion in human ovarian cancer cells via the RhoA/ROCK/MLC pathway , 2017, Molecular medicine reports.

[5]  K. Zhao,et al.  Vincristine promotes migration and invasion of colorectal cancer HCT116 cells through RhoA/ROCK/ Myosin light chain pathway. , 2016, Cellular and molecular biology.

[6]  J. Xiang,et al.  Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF‐κB‐Regulated Anti‐Apoptosis and p53/PCNA‐ and ATM/ATR‐Chk1/2‐Controlled DNA‐Damage Response Pathways , 2016, Journal of cellular biochemistry.

[7]  S. Tyganov,et al.  Key Markers of mTORC1-Dependent and mTORC1-Independent Signaling Pathways Regulating Protein Synthesis in Rat Soleus Muscle During Early Stages of Hindlimb Unloading , 2016, Cellular Physiology and Biochemistry.

[8]  Y. Yoo,et al.  Melatonin Suppresses Autophagy Induced by Clinostat in Preosteoblast MC3T3-E1 Cells , 2016, International journal of molecular sciences.

[9]  Jianjian Shi,et al.  Novel Insights into the Roles of Rho Kinase in Cancer , 2016, Archivum Immunologiae et Therapiae Experimentalis.

[10]  H. Hang,et al.  Increased Sensitivity of DNA Damage Response-Deficient Cells to Stimulated Microgravity-Induced DNA Lesions , 2015, PloS one.

[11]  P. Timpson,et al.  FAK signaling in human cancer as a target for therapeutics. , 2015, Pharmacology & therapeutics.

[12]  L. Vico,et al.  RhoGTPases as Key Players in Mammalian Cell Adaptation to Microgravity , 2015, BioMed research international.

[13]  R. Xavier,et al.  mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity , 2014, Science.

[14]  D. Schlaepfer,et al.  FAK in cancer: mechanistic findings and clinical applications , 2014, Nature Reviews Cancer.

[15]  Molly T Townsend,et al.  Microgravity control of autophagy modulates osteoclastogenesis. , 2014, Bone.

[16]  Sang H. Choi,et al.  Simulated microgravity contributes to autophagy induction by regulating AMP-activated protein kinase. , 2014, DNA and cell biology.

[17]  V. Chau,et al.  RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. , 2014, Cellular signalling.

[18]  M. Parsons,et al.  Integrin-Specific Control of Focal Adhesion Kinase and RhoA Regulates Membrane Protrusion and Invasion , 2013, PloS one.

[19]  L. Zitvogel,et al.  Autophagy and cellular immune responses. , 2013, Immunity.

[20]  J. Asara,et al.  Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 , 2013, Science.

[21]  De Chang,et al.  Simulated microgravity alters the metastatic potential of a human lung adenocarcinoma cell line , 2013, In Vitro Cellular & Developmental Biology - Animal.

[22]  Jens Hauslage,et al.  Ground-based facilities for simulation of microgravity: organism-specific recommendations for their use, and recommended terminology. , 2013, Astrobiology.

[23]  H. Genth,et al.  Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis , 2012, Journal of signal transduction.

[24]  Hongbo Chi,et al.  Regulation and function of mTOR signalling in T cell fate decisions , 2012, Nature Reviews Immunology.

[25]  J. Rathmell,et al.  Metabolic pathways in T cell fate and function. , 2012, Trends in immunology.

[26]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[27]  R. Shaw,et al.  The AMP-activated protein kinase ( AMPK ) signaling pathway coordinates cell growth , autophagy , & metabolism , 2012 .

[28]  H. Hang,et al.  Effects of Simulated Microgravity on Embryonic Stem Cells , 2011, PloS one.

[29]  R. Harrison,et al.  Effects of microgravity on osteoclast bone resorption and osteoblast cytoskeletal organization and adhesion. , 2011, Bone.

[30]  R. Shaw,et al.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.

[31]  Keith Gull,et al.  The evolution of the cytoskeleton , 2011, The Journal of cell biology.

[32]  P. Cossart,et al.  Escherichia coli Producing CNF1 Toxin Hijacks Tollip to Trigger Rac1‐Dependent Cell Invasion , 2011, Traffic.

[33]  B. Viollet,et al.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.

[34]  A. Gomez-Muñoz,et al.  Activation of mTOR and RhoA is a major mechanism by which Ceramide 1-phosphate stimulates macrophage proliferation. , 2011, Cellular signalling.

[35]  L. Trusolino,et al.  MET signalling: principles and functions in development, organ regeneration and cancer , 2010, Nature Reviews Molecular Cell Biology.

[36]  David A. Cheresh,et al.  Integrins in cancer: biological implications and therapeutic opportunities , 2010, Nature Reviews Cancer.

[37]  C. Fiorentini,et al.  Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1): Toxin Biology, in Vivo Applications and Therapeutic Potential , 2010, Toxins.

[38]  J. McDonald,et al.  Modeled microgravity and hindlimb unloading sensitize osteoclast precursors to RANKL-mediated osteoclastogenesis , 2010, Journal of Bone and Mineral Metabolism.

[39]  Jing Li,et al.  Modeled microgravity causes changes in the cytoskeleton and focal adhesions, and decreases in migration in malignant human MCF-7 cells , 2009, Protoplasma.

[40]  J. Bai,et al.  Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion , 2009, British Journal of Cancer.

[41]  D. Radisky,et al.  Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. , 2009, Cancer research.

[42]  B. Geiger,et al.  Environmental sensing through focal adhesions , 2009, Nature Reviews Molecular Cell Biology.

[43]  Jihe Zhao,et al.  Signal transduction by focal adhesion kinase in cancer , 2009, Cancer and Metastasis Reviews.

[44]  S. Miyamoto,et al.  Focal Adhesion Kinase as a RhoA-activable Signaling Scaffold Mediating Akt Activation and Cardiomyocyte Protection* , 2008, Journal of Biological Chemistry.

[45]  H. Nikawa,et al.  Impact of the microgravity environment in a 3‐dimensional clinostat on osteoblast‐ and osteoclast‐like cells , 2008, Cell biology international.

[46]  Z. Dai,et al.  Simulated microgravity inhibits the proliferation and osteogenesis of rat bone marrow mesenchymal stem cells , 2007, Cell proliferation.

[47]  J. Xiang,et al.  Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes. , 2006, Experimental oncology.

[48]  M. Shakibaei,et al.  Simulated weightlessness changes the cytoskeleton and extracellular matrix proteins in papillary thyroid carcinoma cells , 2006, Cell and Tissue Research.

[49]  J. McDonald,et al.  Modeled microgravity inhibits osteogenic differentiation of human mesenchymal stem cells and increases adipogenesis. , 2004, Endocrinology.

[50]  Stéphanie Portet,et al.  Weightlessness acts on human breast cancer cell line MCF-7. , 2003, Advances in space research : the official journal of the Committee on Space Research.

[51]  M Hughes-Fulford,et al.  Function of the cytoskeleton in gravisensing during spaceflight. , 2003, Advances in space research : the official journal of the Committee on Space Research.

[52]  G. Nemerow,et al.  Differential regulation of cell motility and invasion by FAK , 2003, The Journal of cell biology.

[53]  G Gasset,et al.  The effect of weightlessness on cytoskeleton architecture and proliferation of human breast cancer cell line MCF-7. , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[54]  M. Saraste.  Oxidative phosphorylation at the fin de siècle. , 1999, Science.

[55]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[56]  Y Usson,et al.  Effects of intermittent or continuous gravitational stresses on cell-matrix adhesion: quantitative analysis of focal contacts in osteoblastic ROS 17/2.8 cells. , 1997, Experimental cell research.

[57]  C. Fiorentini,et al.  Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine , 1997, Nature.

[58]  G. Lopaschuk,et al.  High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase (*) , 1995, The Journal of Biological Chemistry.

[59]  D. Hardie,et al.  Role of the AMP-activated protein kinase in the cellular stress response , 1994, Current Biology.