论文信息 - Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

Induction of Lymphoma in CDF1 Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

The mutagenic compound, 2‐amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579‐day experiment.

[1] G. Brunborg,et al. Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite. , 1989, Carcinogenesis.

[2] T. Sugimura,et al. Appendix III – Mutagens/Carcinogens in Pyrolysates of Amino Acids and Proteins and in Cooked Foods: Heterocyclic Aromatic Amines* , 1988 .

[3] J. Holme,et al. 4-(2-amino-1-methylimidazo[4,5-b]pyrid-6-yl)phenyl sulfate--a major metabolite of the food mutagen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) in the rat. , 1989, Carcinogenesis.

[4] T. Sugimura,et al. Formation of a mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) in cooked beef, by heating a mixture containing creatinine, phenylalanine and glucose. , 1987, Mutation research.

[5] T. Sugimura,et al. Successful use of short-term tests for academic purposes: their use in identification of new environmental carcinogens with possible risk for humans. , 1988, Mutation research.

[6] F. Hatch,et al. The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). , 1986, Carcinogenesis.

[7] R. Squire. Ranking animal carcinogens: a proposed regulatory approach. , 1981, Science.

[8] T. Sugimura,et al. DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats , 1989, Japanese journal of cancer research : Gann.