Translating Research into Reality: Elimination of Lymphatic Filariasis from Haiti

Abstract. Research provides the essential foundation of disease elimination programs, including the global program to eliminate lymphatic filariasis (GPELF). The development and validation of new diagnostic tools and intervention strategies, critical steps in the evolution of GPELF, required a global effort. Lymphatic filariasis research in Haiti involved many partners and was directly linked to the development of the national elimination program and to the success achieved to date. Ongoing research efforts involving many partners will continue to be important in resolving the challenges faced by the program today in its final efforts to achieve elimination.

[1]  A. Knipes,et al.  Partnering for impact: Integrated transmission assessment surveys for lymphatic filariasis, soil transmitted helminths and malaria in Haiti , 2017, PLoS neglected tropical diseases.

[2]  A. Knipes,et al.  Controlling Neglected Tropical Diseases (NTDs) in Haiti: Implementation Strategies and Evidence of Their Success , 2016, PLoS neglected tropical diseases.

[3]  Mark S. Schmidt,et al.  Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis. , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  E. Ottesen,et al.  Global Programme to Eliminate Lymphatic Filariasis: The Processes Underlying Programme Success , 2014, PLoS neglected tropical diseases.

[5]  Abdel N Direny,et al.  Haiti National Program for the Elimination of Lymphatic Filariasis—A Model of Success in the Face of Adversity , 2014, PLoS neglected tropical diseases.

[6]  M. Deming,et al.  Mass Drug Administration for the Elimination of Lymphatic Filariasis — Port-au-Prince, Haiti, 2011–2012 , 2013, MMWR. Morbidity and mortality weekly report.

[7]  T. Nutman,et al.  Longitudinal Monitoring of the Development of Antifilarial Antibodies and Acquisition of Wuchereria bancrofti in a Highly Endemic Area of Haiti , 2012, PLoS neglected tropical diseases.

[8]  M. Lovegrove,et al.  Secondary Mapping of Lymphatic Filariasis in Haiti-Definition of Transmission Foci in Low-Prevalence Settings , 2012, PLoS neglected tropical diseases.

[9]  S. West,et al.  Development of a new platform for neglected tropical disease surveillance. , 2012, International journal for parasitology.

[10]  Steven A. Williams,et al.  A Multicenter Evaluation of Diagnostic Tools to Define Endpoints for Programs to Eliminate Bancroftian Filariasis , 2012, PLoS neglected tropical diseases.

[11]  D. Addiss,et al.  Feasibility and Effectiveness of Basic Lymphedema Management in Leogane, Haiti, an Area Endemic for Bancroftian Filariasis , 2010, PLoS neglected tropical diseases.

[12]  Shannon K. McClintock,et al.  A Community-Based Study of Factors Associated with Continuing Transmission of Lymphatic Filariasis in Leogane, Haiti , 2010, PLoS neglected tropical diseases.

[13]  P. Lammie,et al.  Assessing the Impact of a Missed Mass Drug Administration in Haiti , 2009, PLoS neglected tropical diseases.

[14]  Peter J Hotez,et al.  Rescuing the bottom billion through control of neglected tropical diseases , 2009, The Lancet.

[15]  D. Addiss,et al.  Predictors of compliance in mass drug administration for the treatment and prevention of lymphatic filariasis in Leogane, Haiti. , 2008, The American journal of tropical medicine and hygiene.

[16]  D. Durrheim,et al.  Current Concepts Control of Neglected Tropical Diseases , 2007 .

[17]  D. Addiss,et al.  Endpoints for Lymphatic Filariasis Programs , 2007, Emerging infectious diseases.

[18]  D. Addiss,et al.  Symptoms reported after mass drug administration for lymphatic filariasis in Leogane, Haiti. , 2006, The American journal of tropical medicine and hygiene.

[19]  P. Gadelha,et al.  Interdigital skin lesions of the lower limbs among patients with lymphoedema in an area endemic for bancroftian filariasis , 2006, Tropical medicine & international health : TM & IH.

[20]  J. Norões,et al.  [Hope Clubs as adjunct therapeutic measure in bancroftian filariasis endemic areas]. , 2006, Revista da Sociedade Brasileira de Medicina Tropical.

[21]  D. Addiss,et al.  Participation in three consecutive mass drug administrations in Leogane, Haiti , 2006, Tropical medicine & international health : TM & IH.

[22]  D. Addiss,et al.  The Leogane, Haiti demonstration project: decreased microfilaremia and program costs after three years of mass drug administration. , 2005, The American journal of tropical medicine and hygiene.

[23]  Peter J Hotez,et al.  “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor , 2005, PLoS medicine.

[24]  D. Addiss,et al.  Clinical correlates of filarial infection in Haitian children: an association with interdigital lesions. , 2005, The American journal of tropical medicine and hygiene.

[25]  M. Beach,et al.  Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children. , 2005, The American journal of tropical medicine and hygiene.

[26]  J. Guarner,et al.  Histopathologic Improvement with Lymphedema Management, Léogâne, Haiti , 2004, Emerging infectious diseases.

[27]  D. Addiss,et al.  Geographic distribution of lymphatic filariasis in Haiti. , 2004, The American journal of tropical medicine and hygiene.

[28]  D. Addiss,et al.  Community-wide reduction in prevalence and intensity of intestinal helminths as a collateral benefit of lymphatic filariasis elimination programs. , 2004, The American journal of tropical medicine and hygiene.

[29]  D. Addiss,et al.  Factors associated with participation in a campaign of mass treatment against lymphatic filariasis, in Leogane, Haiti , 2004, Annals of tropical medicine and parasitology.

[30]  M. Deming,et al.  Comparison of methods for estimating drug coverage for filariasis elimination, Leogane Commune, Haiti. , 2003, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[31]  J. Roberts,et al.  PCR and Mosquito dissection as tools to monitor filarial infection levels following mass treatment , 2003, Filaria journal.

[32]  D. Addiss,et al.  Frequency, severity, and costs of adverse reactions following mass treatment for lymphatic filariasis using diethylcarbamazine and albendazole in Leogane, Haiti, 2000. , 2003, The American journal of tropical medicine and hygiene.

[33]  J. B. Baird,et al.  Reactivity to bacterial, fungal, and parasite antigens in patients with lymphedema and elephantiasis. , 2002, The American journal of tropical medicine and hygiene.

[34]  D. Addiss,et al.  A community-based trial for the control of lymphatic filariasis and iodine deficiency using salt fortified with diethylcarbamazine and iodine. , 2001, The American journal of tropical medicine and hygiene.

[35]  J. Norões,et al.  New insights into the natural history and pathology of bancroftian filariasis: implications for clinical management and filariasis control programmes. , 2000, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[36]  R. K. Shenoy,et al.  An analysis of the safety of the single dose, two drug regimens used in programmes to eliminate lymphatic filariasis , 2000, Parasitology.

[37]  N. Leal,et al.  Acute attacks in the extremities of persons living in an area endemic for bancroftian filariasis: differentiation of two syndromes. , 1999, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[38]  D. Addiss,et al.  Controlling morbidity and interrupting transmission: twin pillars of lymphatic filariasis elimination. , 1999, Revista da Sociedade Brasileira de Medicina Tropical.

[39]  J. Roberts,et al.  Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren. , 1999, The American journal of tropical medicine and hygiene.

[40]  J. Roberts,et al.  Longitudinal analysis of the development of filarial infection and antifilarial immunity in a cohort of Haitian children. , 1998, The American journal of tropical medicine and hygiene.

[41]  G. Weil,et al.  The ICT Filariasis Test: A rapid-format antigen test for diagnosis of bancroftian filariasis. , 1997, Parasitology today.

[42]  A. Hightower,et al.  Clearance of Wuchereria bancrofti antigen after treatment with diethylcarbamazine or ivermectin. , 1997, The American journal of tropical medicine and hygiene.

[43]  A. Hightower,et al.  Randomised placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaraemia in Haitian children , 1997, The Lancet.

[44]  D. Addiss,et al.  Clinical, parasitologic, and immunologic observations of patients with hydrocele and elephantiasis in an area with endemic lymphatic filariasis. , 1995, The Journal of infectious diseases.

[45]  A. Hightower,et al.  Age-specific prevalence of antigenemia in a Wuchereria bancrofti-exposed population. , 1994, The American journal of tropical medicine and hygiene.

[46]  D. Addiss,et al.  "Filarial" adenolymphangitis without filarial infection , 1994, The Lancet.

[47]  A. Hightower,et al.  Maternal filarial infection - a persistent risk factor for microfilaremia in offspring? , 1993, Parasitology today.

[48]  A. Hightower,et al.  Heterogeneity in filarial-specific immune responsiveness among patients with lymphatic obstruction. , 1993, The Journal of infectious diseases.

[49]  D. Addiss,et al.  Comparative efficacy of clearing-dose and single high-dose ivermectin and diethylcarbamazine against Wuchereria bancrofti microfilaremia. , 1993, The American journal of tropical medicine and hygiene.

[50]  A. Hightower,et al.  Long-term suppression of microfilaraemia following ivermectin treatment. , 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[51]  A. Hightower,et al.  Bancroftian filariasis: long-term effects of treatment with diethylcarbamazine in a Haitian population. , 1991, The American journal of tropical medicine and hygiene.

[52]  G. Weil,et al.  Changes in circulating parasite antigen levels after treatment of bancroftian filariasis with diethylcarbamazine and ivermectin. , 1991, The Journal of infectious diseases.

[53]  G. Weil,et al.  Evaluation of a monoclonal-antibody based antigen assay for diagnosis of Wuchereria bancrofti infection in Egypt. , 1991, The American journal of tropical medicine and hygiene.

[54]  J. Roberts,et al.  Evidence of Nonsusceptibihty to Diethylcarbamazine in Wucheria bancrofti , 1991 .

[55]  A. Hightower,et al.  Maternal filarial infection as risk factor for infection in children , 1991, The Lancet.

[56]  D. Addiss,et al.  Tolerance of single high-dose ivermectin for treatment of lymphatic filariasis. , 1991, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[57]  S. More,et al.  A highly specific and sensitive monoclonal antibody-based ELISA for the detection of circulating antigen in bancroftian filariasis. , 1990, Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit.

[58]  C. Raccurt,et al.  Uptake and development of Wuchereria bancrofti in Culex quinquefasciatus that fed on Haitian carriers with different microfilaria densities. , 1989, The American journal of tropical medicine and hygiene.

[59]  J. Roberts,et al.  Effectiveness of spaced doses of diethylcarbamazine citrate for the control of bancroftian filariasis. , 1989, Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit.

[60]  P. Lammie,et al.  Persistence of microfilaremia in bancroftian filariasis after diethylcarbamazine citrate therapy. , 1988, Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit.

[61]  D. Addiss,et al.  Evaluation of antibacterial soap in the management of lymphoedema in Leogane, Haiti. , 2011, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[62]  J. Roberts,et al.  Evidence of nonsusceptibility to diethylcarbamazine in Wuchereria bancrofti. , 1991, The Journal of infectious diseases.

[63]  A. Hightower,et al.  Comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti. , 1991, The American journal of tropical medicine and hygiene.

[64]  N. G. Kamalov [Human filariasis]. , 1953, Meditsinskaia parazitologiia i parazitarnye bolezni.