Dual pH- and temperature-responsive RAFT-based block co-polymer micelles and polymer–protein conjugates with transient solubility

Via a smart combination of temperature-responsive and acid labile acetal monomers, copolymers are obtained with a la carte lower critical solution temperature behavior. RAFT copolymerization of these monomers using, respectively, a PEG-functionalized or amine-reactive NHS-functionalized chain transfer agent allows designing of micelles and polymer–protein conjugates with transient solubility properties within a physiologically relevant window.

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