Systematic summarizing clinical efficacies of wrinkled giant hyssop to provide references for clinician's medication. Clinical efficacies of wrinkled giant hyssop can be summarized as: dissolving damp with aromatics, regulating qi to soothe zhongjiao (the middle heater); relieve summer-heat and cure cholera, expel dampness and relieving the exterior; militating zhongjiao (the middle heater) to stop vomitting, warming spleen to relieve pain; regulating qi to prevent miscarriage, relieving asthma by depressing upward-reverse flow of qi; oral deodorization, relieve swelling and hastening rupture.