Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial

[1]  Life Study Investigators.  Effect of Physical Activity on Frailty: Secondary Analysis of a Randomized Controlled Trial , 2018 .

[2]  Michelle Brasure,et al.  Physical Activity Interventions in Preventing Cognitive Decline and Alzheimer-Type Dementia , 2017, Annals of Internal Medicine.

[3]  G. Logroscino,et al.  Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging. , 2017, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[4]  M. Izquierdo,et al.  Role of physical exercise on cognitive function in healthy older adults: A systematic review of randomized clinical trials , 2017, Ageing Research Reviews.

[5]  B. Pedersen.  Anti‐inflammatory effects of exercise: role in diabetes and cardiovascular disease , 2017, European journal of clinical investigation.

[6]  B. Vellas,et al.  Cognitive Frailty: Mechanisms, Tools to Measure, Prevention and Controversy. , 2017, Clinics in geriatric medicine.

[7]  Nicolas Cherbuin,et al.  Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis , 2017, British Journal of Sports Medicine.

[8]  F. Panza,et al.  Emerging biomarkers and screening for cognitive frailty , 2017, Aging Clinical and Experimental Research.

[9]  Qi Gao,et al.  Cognitive Frailty and Adverse Health Outcomes: Findings From the Singapore Longitudinal Ageing Studies (SLAS). , 2017, Journal of the American Medical Directors Association.

[10]  T. Dorner,et al.  Effects of a Home-Based and Volunteer-Administered Physical Training, Nutritional, and Social Support Program on Malnutrition and Frailty in Older Persons: A Randomized Controlled Trial. , 2016, Journal of the American Medical Directors Association.

[11]  P. Manckoundia,et al.  Analysis of Inappropriate Admissions of Residents of Medicalized Nursing Homes to Emergency Departments: A Prospective Multicenter Study in Burgundy. , 2016, Journal of the American Medical Directors Association.

[12]  Mari Carmen Gómez-Cabrera,et al.  A Multicomponent Exercise Intervention that Reverses Frailty and Improves Cognition, Emotion, and Social Networking in the Community-Dwelling Frail Elderly: A Randomized Clinical Trial. , 2016, Journal of the American Medical Directors Association.

[13]  H. Makizako,et al.  Impact of cognitive frailty on daily activities in older persons , 2016, Alzheimer's & Dementia.

[14]  J. Millán-Calenti,et al.  Effects of physical exercise interventions in frail older adults: a systematic review of randomized controlled trials , 2015, BMC Geriatrics.

[15]  G. Logroscino,et al.  Cognitive Frailty: A Systematic Review of Epidemiological and Neurobiological Evidence of an Age-Related Clinical Condition. , 2015, Rejuvenation research.

[16]  A. Cano.  Cognitive frailty, a new target for healthy ageing. , 2015, Maturitas.

[17]  J. Williamson,et al.  Effect of a 24-Month Physical Activity Intervention vs Health Education on Cognitive Outcomes in Sedentary Older Adults: The LIFE Randomized Trial. , 2015, JAMA.

[18]  Michael E. Miller,et al.  A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. , 2015, The journals of gerontology. Series A, Biological sciences and medical sciences.

[19]  M. Cesari,et al.  Frailty and cognitive decline: how do they relate? , 2015, Current opinion in clinical nutrition and metabolic care.

[20]  J. Williamson,et al.  The LIFE Cognition Study: design and baseline characteristics , 2014, Clinical interventions in aging.

[21]  T. Manini,et al.  Patterns of Circulating Inflammatory Biomarkers in Older Persons with Varying Levels of Physical Performance: A Partial Least Squares-Discriminant Analysis Approach , 2014, Front. Med..

[22]  Michael E. Miller,et al.  Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. , 2014, JAMA.

[23]  P. Fayers,et al.  Weight loss, appetite loss and food intake in cancer patients with cancer cachexia: Three peas in a pod? – analysis from a multicenter cross sectional study , 2014, Acta oncologica.

[24]  S. Espinoza,et al.  Plasma protein biomarkers of the geriatric syndrome of frailty. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[25]  R. Roubenoff.  The "cytokine for gerontologists" has some company. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[26]  A. Woods,et al.  Cognitive frailty: Frontiers and challenges , 2013, The journal of nutrition, health & aging.

[27]  M. Cesari,et al.  Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group , 2013, The journal of nutrition, health & aging.

[28]  G. Savva,et al.  Frailty and cognitive impairment—A review of the evidence and causal mechanisms , 2013, Ageing Research Reviews.

[29]  N. Sattar,et al.  Circulating interleukin‐6 concentration and cognitive decline in old age: the PROSPER study , 2013, Journal of internal medicine.

[30]  J. M. D. Dias,et al.  Frailty and cognitive impairment among community-dwelling elderly. , 2013, Arquivos de neuro-psiquiatria.

[31]  C. Cooper,et al.  Inflammatory markers and incident frailty in men and women: the English Longitudinal Study of Ageing , 2013, AGE.

[32]  M. Catt,et al.  Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study , 2012, Mechanisms of Ageing and Development.

[33]  Michael E. Miller,et al.  The Lifestyle Interventions and Independence for Elders Study: Design and Methods , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  S. Leng,et al.  Inflammation and immune system alterations in frailty. , 2011, Clinics in geriatric medicine.

[35]  G. Ostir,et al.  Cognitive status and future risk of frailty in older Mexican Americans. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[36]  Jean-François Dartigues,et al.  Cognitive Impairment Improves the Predictive Validity of the Phenotype of Frailty for Adverse Health Outcomes: The Three‐City Study , 2009, Journal of the American Geriatrics Society.

[37]  Brent C Taylor,et al.  Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. , 2008, Archives of internal medicine.

[38]  L. Fried,et al.  Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. , 2007, Archives of internal medicine.

[39]  L. Ferrucci,et al.  Interleukin-6 in aging and chronic disease: a magnificent pathway. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[40]  M. Visser,et al.  Endocrine and inflammatory markers as predictors of frailty , 2005, Clinical endocrinology.

[41]  L. Fried,et al.  Chronic Cytomegalovirus Infection and Inflammation Are Associated with Prevalent Frailty in Community‐Dwelling Older Women , 2005, Journal of the American Geriatrics Society.

[42]  L. Fried,et al.  Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. , 2002, Archives of internal medicine.

[43]  Luigi Ferrucci,et al.  Serum IL‐6 Level and the Development of Disability in Older Persons , 1999, Journal of the American Geriatrics Society.

[44]  E. Heath.  Borg's Perceived Exertion and Pain Scales , 1998 .

[45]  G. Borg.  Borg's Perceived Exertion and Pain Scales , 1998 .

[46]  W. Ershler,et al.  Interleukin‐6: A Cytokine for Gerontolgists , 1993, Journal of the American Geriatrics Society.

[47]  H. Chui,et al.  The Modified Mini-Mental State (3MS) examination. , 1987, The Journal of clinical psychiatry.

[48]  M. Weissman,et al.  Assessing depressive symptoms in five psychiatric populations: a validation study. , 1977, American journal of epidemiology.

[49]  R. Brown,et al.  Assessing the current state of cognitive frailty: Measurement properties , 2016, The journal of nutrition, health & aging.

[50]  G. Logroscino,et al.  Targeting Cognitive Frailty: Clinical and Neurobiological Roadmap for a Single Complex Phenotype. , 2015, Journal of Alzheimer's disease : JAD.

[51]  Michael E. Miller,et al.  Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[52]  R. Sacco,et al.  Interleukin-6 is associated with cognitive function: the Northern Manhattan Study. , 2006, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[53]  J. Nazroo.  The English Longitudinal Study of Ageing (ELSA): A new data resource on health, economic position and quality of life for older people , 2001 .