Zinc intake, status and indices of cognitive function in adults and children: Q1 a systematic review and meta-analysis

s screened (n=5635) Records excluded (n= 3447) Reasons include: no zinc intake-statushealth associations reported, not eligible study design, not eligible zinc biomarker, not eligible health outcome. Publications reporting zinc and indices of cognitive function that meet the EURRECA inclusion criteria (n=18) Randomised Controlled Trials Children (n= 11) Adult (n=1) Observational studies Children (n= 2) Pregnant women (n= 1) Adult (n=3) Full text articles assessed for eligibility (n= 2188) (Included N°of studies from updated search to March 2014 (n=13) Intake-status-health Infant studies (n= 356) Included in the metaanalysis from Children group (n= 6) Intake-status studies (n= 174) Figure 1. Study selection process for the systematic review. Zinc and cognition M Warthon-Medina et al 3 © 2015 Macmillan Publishers Limited European Journal of Clinical Nutrition (2015), 1 – 13 Ta bl e 2a . C h ar ac te ri st ic s o f id en ti fi ed st u d ie s as se ss in g zi n c in ta ke /s ta tu s an d co g n it iv e fu n ct io n .R an d o m is ed co n tr o lle d tr ia ls (n = 12 ) re p o rt in g th e ef fe ct o f d ie ta ry zi n c in ta ke /s er u m o r p la sm a zi n c st at u s o n co g n it iv e fu n ct io n in ad u lt s an d ch ild re n St ud y, ye ar ,c ou nt ry Se x, ag e Tr ea tm en t gr ou ps M ic ro nu tr ie nt ty pe D ur at io n O ut co m e m ea su re M ai n re su lts A du lts M ay lo r et al . 5 6 U K Fr an ce It al y 18 8 M al es an d fe m al es ag ed