Factors influencing susceptibility to compulsive dopaminergic drug use in Parkinson disease

Background: In the course of treatment, a small group of patients with Parkinson disease (PD) develop a harmful pattern of compulsive dopaminergic drug use, called the dopamine dysregulation syndrome (DDS). Individual factors may influence susceptibility. Objectives: To identify predisposing factors to DDS in a population of outpatients with PD. Methods: The authors compared clinical features, impulsive sensation seeking (ISS) personality traits, past experimental drug use, alcohol consumption, smoking behaviors, and depressive symptoms in 25 patients with DDS to an outpatient sample of 100 patients with PD who were not compulsively overusing dopaminergic medication. Results: Patients with DDS had a significantly younger age at disease onset, higher dopaminergic drug intake, greater past experimental drug use, more depressive symptoms, scored higher on ISS ratings, and tended to have higher alcohol intake. Using logistic regression analysis, we found that novelty seeking personality traits, depressive symptoms, alcohol intake, and age at PD onset were significant predictors of DDS. Conclusions: These factors may help to identify early patients who are more vulnerable to developing a pattern of compulsive dopaminergic drug use and help minimize its consequences.

[1]  J. Régis,et al.  Addiction in Parkinson's disease: Impact of subthalamic nucleus deep brain stimulation , 2005, Movement disorders : official journal of the Movement Disorder Society.

[2]  Erwan Bezard,et al.  Involvement of Sensorimotor, Limbic, and Associative Basal Ganglia Domains in L-3,4-Dihydroxyphenylalanine-Induced Dyskinesia , 2005, The Journal of Neuroscience.

[3]  Andrew Evans,et al.  Continuous subcutaneous apomorphine therapy improves dyskinesias in Parkinson's disease: A prospective study using single‐dose challenges , 2005, Movement disorders : official journal of the Movement Disorder Society.

[4]  C. Colosimo,et al.  Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's disease , 2005, Movement disorders : official journal of the Movement Disorder Society.

[5]  A. Lees,et al.  Recognition of a dopamine replacement therapy dependence syndrome in Parkinson's disease: a pilot study. , 2004, Drug and alcohol dependence.

[6]  Nora D. Volkow,et al.  The reality of comorbidity: Depression and drug abuse , 2004, Biological Psychiatry.

[7]  Ladislav Hosák,et al.  Temperament and character inventory (TCI) personality profile in metamphetamine abusers: a controlled study , 2004, European Psychiatry.

[8]  Regina Katzenschlager,et al.  Punding in Parkinson's disease: Its relation to the dopamine dysregulation syndrome , 2004, Movement disorders : official journal of the Movement Disorder Society.

[9]  L. Parsons,et al.  Neurobiological mechanisms in the transition from drug use to drug dependence , 2004, Neuroscience & Biobehavioral Reviews.

[10]  M. Moal,et al.  Repeated stress increases locomotor response to amphetamine , 2004, Psychopharmacology.

[11]  C. Lerman,et al.  Which Adolescents Are Most Receptive to Tobacco Industry Marketing? Implications for Counter-Advertising Campaigns , 2003, Health communication.

[12]  A. Lawrence,et al.  Compulsive use of dopamine replacement therapy in Parkinson's disease: reward systems gone awry? , 2003, The Lancet Neurology.

[13]  JaneR . Taylor,et al.  Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. , 2003, The American journal of psychiatry.

[14]  Sheri L. Johnson,et al.  BIS/BAS Levels and Psychiatric Disorder: An Epidemiological Study , 2003 .

[15]  R. Malenka,et al.  Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons , 2003, Neuron.

[16]  N. el-Guebaly,et al.  Relationship between craving and personality in treatment-seeking women with substance-related disorders , 2003, BMC psychiatry.

[17]  A. Dagher,et al.  Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking: A PET/[11C]Raclopride Study in Healthy Men , 2002, Neuropsychopharmacology.

[18]  D. Burn.  Beyond the iron mask: Towards better recognition and treatment of depression associated with Parkinson's disease , 2002, Movement disorders : official journal of the Movement Disorder Society.

[19]  L. Donohew,et al.  Television campaigns and adolescent marijuana use: tests of sensation seeking targeting. , 2001, American journal of public health.

[20]  J. Gray,et al.  Dopamine, appetitive reinforcement, and the neuropsychology of human learning: An individual differences approach , 2001 .

[21]  R. Cantello.  Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies , 2000, Journal of neurology, neurosurgery, and psychiatry.

[22]  K. Sher,et al.  Personality and substance use disorders: a prospective study. , 2000, Journal of consulting and clinical psychology.

[23]  G. Wardeh,et al.  Unrestricted free-choice ethanol self-administration in rats causes long-term neuroadaptations in the nucleus accumbens and caudate putamen , 1999, Psychopharmacology.

[24]  K. Hornik,et al.  The Tridimensional Personality Questionnaire as a predictor of relapse in detoxified alcohol dependents. The European Fluvoxamine in Alcoholism Study Group. , 1999, Alcoholism, clinical and experimental research.

[25]  A. Phillips,et al.  Facilitation of sexual behavior in male rats following d-amphetamine-induced behavioral sensitization , 1999, Psychopharmacology.

[26]  G. Phillips,et al.  Enhanced appetitive conditioning following repeated pretreatment with d-amphetamine. , 1998, Behavioural pharmacology.

[27]  G. Brannigan,et al.  Experiences in Personality: Research, Assessment, and Change , 1997 .

[28]  C. R. Cloninger,et al.  Relationships between Cloninger's, Zuckerman's, and Eysenck's dimensions of personality. , 1996, Personality and individual differences.

[29]  M. Bardo,et al.  Psychobiology of novelty seeking and drug seeking behavior , 1996, Behavioural Brain Research.

[30]  C. Carver,et al.  Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS Scales , 1994 .

[31]  M. Zuckerman.  Behavioral Expressions and Biosocial Bases of Sensation Seeking , 1994 .

[32]  C. R. Cloninger,et al.  A psychobiological model of temperament and character. , 1993, Archives of general psychiatry.

[33]  R. Pihl,et al.  Factor structure and correlates of the Tridimensional Personality Questionnaire. , 1992, Journal of studies on alcohol.

[34]  E. Rimm,et al.  The assessment of alcohol consumption by a simple self-administered questionnaire. , 1991, American journal of epidemiology.

[35]  C. Robert Cloninger,et al.  Childhood personality predicts alcohol abuse in young adults. , 1988, Alcoholism, clinical and experimental research.

[36]  C. Robert Cloninger,et al.  Neurogenetic adaptive mechanisms in alcoholism. , 1987, Science.

[37]  A. Logue,et al.  Predictors of food preferences in adult humans , 1986, Appetite.

[38]  V. Leirer,et al.  Development and validation of a geriatric depression screening scale: a preliminary report. , 1982, Journal of psychiatric research.