Seeing cells in a new light: a renaissance of Brillouin spectroscopy

Over the years, light scattering from acoustic waves has grown to be increasingly important in the fields of biology and medicine. This type of scattering, known as Brillouin scattering, has already seen a plethora of applications in fields such as physics. However, the potential for Brillouin scattering for medical imaging and diagnostics has only recently been considered. In this work, we summarize most of the applications of Brillouin scattering in biology to date, and some current work in our lab showing how Brillouin scattering is a worthy prospect for many emerging problems in biology and medical diagnostics.

[1]  M. Smoluchowski Molekular-kinetische Theorie der Opaleszenz von Gasen im kritischen Zustande, sowie einiger verwandter Erscheinungen , 1908 .

[2]  A. Einstein,et al.  Theorie der Opaleszenz von homogenen Flüssigkeiten und Flüssigkeitsgemischen in der Nähe des kritischen Zustandes [AdP 33, 1275 (1910)] , 2005, Annalen der Physik.

[3]  L. Brillouin Diffusion de la lumière et des rayons X par un corps transparent homogène - Influence de l'agitation thermique , 1922 .

[4]  H. E. Wimperis Magnetic Conditions in Tube Railways , 1925, Nature.

[5]  E. Gross,et al.  Fine Structure of Optically Excited Spectrum Lines , 1925, Nature.

[6]  H. L. Brose,et al.  The Atomic Diameters of Hydrogen and the Inert Gases with respect to Electrons of Very Low Velocity. , 1930, Nature.

[7]  E. Gross The Splitting of Spectral Lines at Scattering of Light by Liquids. , 1930, Nature.

[8]  E. Gross Change of Wave-length of Light due to Elastic Heat Waves at Scattering in Liquids. , 1930, Nature.

[9]  E. Gross Splitting of the Frequency of Light scattered by Liquids and Optical Anisotropy of Molecules. , 1930, Nature.

[10]  E. Gross Modification of Light Quanta by Elastic Heat Oscillations in Scattering Media , 1932, Nature.

[11]  S. E. Schwarz,et al.  Stimulated Raman Scattering From Organic Liquids , 1962 .

[12]  M. Geller,et al.  STIMULATED EMISSION OF STOKES AND ANTI‐STOKES RAMAN LINES FROM DIAMOND, CALCITE, AND α‐SULFUR SINGLE CRYSTALS , 1963 .

[13]  Robert W. Hellwarth,et al.  Analysis of Stimulated Raman Scattering of a Giant Laser Pulse , 1963 .

[14]  C. Townes,et al.  Stimulated Brillouin Scattering and Coherent Generation of Intense Hypersonic Waves , 1964 .

[15]  Nicolaas Bloembergen,et al.  Theory of Stimulated Brillouin and Raman Scattering , 1965 .

[16]  F. G. Bolton,et al.  Estimation of cerebrospinal fluid protein , 1968, Journal of clinical pathology.

[17]  J. R. Sandercock,et al.  Brillouin scattering study of SbSI using a double-passed, stabilised scanning interferometer , 1970 .

[18]  Robert L. Byer,et al.  Coherent anti-Stokes Raman spectroscopy , 1974 .

[19]  R R Hook,et al.  Melanoma in Sinclair swine: a new animal model. , 1974, The Journal of investigative dermatology.

[20]  Chandrasekhar Roychoudhuri Demonstrations using a Fabry–Perot. I. Multiple‐slit interference , 1975 .

[21]  D. Jackson,et al.  Brillouin scattering study of gelatin gel using a double passed Fabry-Perot spectrometer , 1976 .

[22]  Don Heiman,et al.  Raman-Induced Kerr Effect , 1976 .

[23]  M. Levenson,et al.  Raman-induced Kerr effect with elliptical polarization* , 1976 .

[24]  S. Lindsay,et al.  Correction of Brillouin linewidths measured by multipass Fabry-Perot spectroscopy. , 1977, Applied optics.

[25]  J. White,et al.  Phonons and the elastic moduli of collagen and muscle , 1977, Nature.

[26]  H. Eichler Laser-induced Grating Phenomena , 1977 .

[27]  P. Pershan,et al.  Brillouin light scattering measurement of the elastic properties of aligned multilamella lipid samples. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S Cusack,et al.  Determination of the elastic constants of collagen by Brillouin light scattering. , 1979, Journal of molecular biology.

[29]  Yaochun Shen,et al.  Coherent Brillouin Spectroscopy , 1979 .

[30]  J. Randall,et al.  Brillouin scattering in systems of biological significance , 1979, Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences.

[31]  G. Maret,et al.  Velocity of high frequency sound waves in oriented DNA fibres and films determined by Brillouin scattering , 1979 .

[32]  Keith A. Nelson,et al.  Laser induced phonons: A probe of intermolecular interactions in molecular solids , 1980 .

[33]  C. Alling,et al.  A comparative study of three approaches to the routine quantitative determination of spinal fluid total proteins. , 1980, Clinica chimica acta; international journal of clinical chemistry.

[34]  J. Randall,et al.  Brillouin scattering, density and elastic properties of the lens and cornea of the eye , 1980, Nature.

[35]  G. Stegeman,et al.  Enhanced Brillouin scattering involving surface plasmon polaritons , 1981 .

[36]  K. Nelson,et al.  Laser-induced phonon spectroscopy. Optical generation of ultrasonic waves and investigation of electronic excited-state interactions in solids , 1981 .

[37]  S. Lindsay,et al.  The speed of sound in DNA , 1984, Biopolymers.

[38]  J. Fujimoto,et al.  Femtosecond time-resolved measurements of optic phonon dephasing by impulsive stimulated raman scattering in α-perylene crystal from 20 to 300 K , 1985 .

[39]  G. Schmidt,et al.  Compressibility of lysozyme in solution from time-resolved brillouin difference spectroscopy. , 1985, Biopolymers.

[40]  K. Nelson,et al.  Coherent molecular vibrational motion observed in the time domain through impulsive stimulated Raman scattering , 1988 .

[41]  K. Nelson,et al.  Ultrasonic and hypersonic properties of molten KNO3–Ca(NO3)2 mixture , 1989 .

[42]  J. Vaughan,et al.  Observation of Brillouin scattering from single muscle fibres , 1989, European Biophysics Journal.

[43]  K. Abe,et al.  Optical Heterodyned Coherent Brillouin Spectroscopy (OHD-BIKES) Using Continuous-Wave (cw) Dye Lasers , 1989 .

[44]  R. Miller,et al.  Picosecond transient thermal phase grating spectroscopy: A new approach to the study of vibrational energy relaxation processes in proteins , 1989 .

[45]  S Lees,et al.  Studies of compact hard tissues and collagen by means of Brillouin light scattering. , 1990, Connective tissue research.

[46]  G. Wiederrecht,et al.  Femtosecond multiple-pulse impulsive stimulated Raman scattering spectroscopy , 1991 .

[47]  K. Nelson,et al.  Picosecond–microsecond structural relaxation dynamics in polypropylene glycol: Impulsive stimulated light‐scattering experiments , 1991 .

[48]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.

[49]  Y. Takagi,et al.  Application of a microscope to Brillouin scattering spectroscopy , 1992 .

[50]  R. Miller,et al.  Picosecond phase grating spectroscopy of hemoglobin and myoglobin: energetics and dynamics of global protein motion. , 1992, Biochemistry.

[51]  Masashi Yamaguchi,et al.  New high‐resolution phonon spectroscopy using impulsive stimulated Brillouin scattering , 1993 .

[52]  D. Ingber,et al.  Mechanotransduction across the cell surface and through the cytoskeleton , 1993 .

[53]  M. Misfeldt,et al.  Sinclair miniature swine: an animal model of human melanoma. , 1994, Veterinary immunology and immunopathology.

[54]  M. Poulin,et al.  Second-harmonic generation of a 1560-nm distributed-feedback laser by use of a KNbO(3) crystal for frequency locking to the (87)Rb D(2) line at 780 nm. , 1994, Optics letters.

[55]  M. Shirasaki Large angular dispersion by a virtually imaged phased array and its application to a wavelength demultiplexer. , 1996, Optics letters.

[56]  S. Kojima,et al.  Quick Measurement of Brillouin Spectra of Glass-Forming Material Trimethylene Glycol by Angular Dispersion-Type Fabry-Perot Interferometer System. , 1996 .

[57]  R. Dasari,et al.  Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS) , 1997 .

[58]  Steven R. Emory,et al.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering , 1997, Science.

[59]  R. Nau,et al.  Enzyme Immunoassay Detecting Teichoic and Lipoteichoic Acids versus Cerebrospinal Fluid Culture and Latex Agglutination for Diagnosis of Streptococcus pneumoniae Meningitis , 1998, Journal of Clinical Microbiology.

[60]  Measurement of the power distribution during stimulated Brillouin scattering with focused Gaussian beams , 1998 .

[61]  R Zenobi,et al.  Near-Field Surface-Enhanced Raman Imaging of Dye-Labeled DNA with 100-nm Resolution. , 1998, Analytical chemistry.

[62]  F. Horak,et al.  Comparative Tolerability of Second Generation Antihistamines , 1999, Drug safety.

[63]  E. Meltzer,et al.  Desloratadine: A new, nonsedating, oral antihistamine. , 2001, The Journal of allergy and clinical immunology.

[64]  J. S. Lee,et al.  A linear relation between the compressibility and density of blood. , 2001, The Journal of the Acoustical Society of America.

[65]  A. Tunkel,et al.  Treatment of bacterial meningitis , 2002, Current infectious disease reports.

[66]  Michael S. Feld,et al.  Surface-Enhanced Raman Spectroscopy in Single Living Cells Using Gold Nanoparticles , 2002 .

[67]  Vladislav V. Yakovlev Advanced instrumentation for non‐linear Raman microscopy , 2003 .

[68]  T. Champel,et al.  Comment on "London theory for superconducting phase transitions in external magnetic fields: application to UPt3". , 2002, Physical review letters.

[69]  R. Booy,et al.  Diagnosis and treatment of bacterial meningitis , 2003, Archives of disease in childhood.

[70]  M. Trotter,et al.  Treatment of Cutaneous Melanoma of the Face by Mohs Micrographic Surgery , 2003, Journal of cutaneous medicine and surgery.

[71]  W. Brown,et al.  Sighted automation and fine resolution imaging , 2004, IEEE Transactions on Aerospace and Electronic Systems.

[72]  S. Salminen,et al.  The allergy epidemic extends beyond the past few decades , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[73]  C. Ganellin,et al.  Histamine and its receptors , 2006, British journal of pharmacology.

[74]  J. Fredberg,et al.  Fast and slow dynamics of the cytoskeleton , 2006, Nature materials.

[75]  Subra Suresh,et al.  Nanomedicine: elastic clues in cancer detection. , 2007, Nature nanotechnology.

[76]  S. Yun,et al.  Confocal Brillouin microscopy for three-dimensional mechanical imaging. , 2007, Nature photonics.

[77]  Pablo G. Etchegoin,et al.  Surface Enhanced Raman Scattering Enhancement Factors: A Comprehensive Study , 2007 .

[78]  A. McPherson,et al.  Elastic properties of viruses. , 2007, Biophysical journal.

[79]  J. Rao,et al.  Nanomechanical analysis of cells from cancer patients. , 2007, Nature nanotechnology.

[80]  R. Vaia,et al.  How rigid are viruses. , 2008, Physical review. E, Statistical, nonlinear, and soft matter physics.

[81]  Fabien Guillemot,et al.  In Vitro picosecond ultrasonics in a single cell , 2008 .

[82]  S. Holgate,et al.  Treatment strategies for allergy and asthma , 2008, Nature Reviews Immunology.

[83]  Edward S. Fry,et al.  Depth-resolved temperature measurements of water using the Brillouin lidar technique , 2009 .

[84]  B. Draine,et al.  Optimization of Arrays of Gold Nanodisks for Plasmon-Mediated Brillouin Light Scattering , 2009 .

[85]  F. Guillemot,et al.  Picosecond acoustics in vegetal cells: non-invasive in vitro measurements at a sub-cell scale. , 2010, Ultrasonics.

[86]  A. Khademhosseini,et al.  Cell-laden microengineered gelatin methacrylate hydrogels. , 2010, Biomaterials.

[87]  C. Tek,et al.  Association of Prescription H1 Antihistamine Use With Obesity: Results From the National Health and Nutrition Examination Survey , 2010, Obesity.

[88]  Xiaoyi Bao,et al.  Characterization of the Brillouin grating spectra in a polarization-maintaining fiber. , 2010, Optics express.

[89]  C. Garbe,et al.  Excision guidelines and follow-up strategies in cutaneous melanoma: Facts and controversies. , 2010, Clinics in dermatology.

[90]  F. Simons,et al.  Histamine and H1-antihistamines: celebrating a century of progress. , 2011, The Journal of allergy and clinical immunology.

[91]  S. Yun,et al.  Multistage VIPA etalons for high-extinction parallel Brillouin spectroscopy , 2011, Optics express.

[92]  Pilhan Kim,et al.  In vivo measurement of age-related stiffening in the crystalline lens by Brillouin optical microscopy. , 2011, Biophysical journal.

[93]  K. Nelson,et al.  Coherent Brillouin spectroscopy in a strongly scattering liquid by picosecond ultrasonics. , 2011, Optics letters.

[94]  R. Katial,et al.  Antihistamine therapy in allergic rhinitis. , 2011, Immunology and allergy clinics of North America.

[95]  Single-shot tomography by means of VIPA and spatial phase modulator installed optical interferometer , 2011 .

[96]  Guillaume Haiat,et al.  Micro-Brillouin scattering measurements in mature and newly formed bone tissue surrounding an implant. , 2011, Journal of biomechanical engineering.

[97]  G. Thwaites,et al.  Dilemmas in the diagnosis of acute community-acquired bacterial meningitis , 2012, The Lancet.

[98]  S. Yun,et al.  In vivo Brillouin optical microscopy of the human eye , 2012, Optics express.

[99]  Kevin J. Parker,et al.  Corrigendum: Imaging the elastic properties of tissue: the 20 year perspective , 2012 .

[100]  Choon Kiat Lim,et al.  Nanotopography modulates mechanotransduction of stem cells and induces differentiation through focal adhesion kinase. , 2013, ACS nano.

[101]  O. Wright,et al.  Mapping gigahertz vibrations in a plasmonic–phononic crystal , 2013 .

[102]  Vladislav V. Yakovlev,et al.  Microscopic coherent Raman imaging using low-cost continuous wave lasers , 2013 .

[103]  G. McKinley,et al.  Power-law rheology in the bulk and at the interface: quasi-properties and fractional constitutive equations , 2013, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[104]  Vladislav V. Yakovlev,et al.  Continuous-wave stimulated Raman scattering (cwSRS) microscopy , 2013, Applied physics. B, Lasers and optics.

[105]  Eric M. Strohm,et al.  High frequency label-free photoacoustic microscopy of single cells☆ , 2013, Photoacoustics.

[106]  Carl Paterson,et al.  Spectral broadening in Brillouin imaging , 2013 .

[107]  Ali Khademhosseini,et al.  Nanocomposite hydrogels for biomedical applications. , 2014, Biotechnology and bioengineering.

[108]  Vladislav V. Yakovlev,et al.  Background clean-up in Brillouin microspectroscopy of scattering medium. , 2014, Optics express.

[109]  J. Luyendyk,et al.  H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. , 2014, American journal of physiology. Gastrointestinal and liver physiology.

[110]  Andreas Rudolf,et al.  Laboratory demonstration of a Brillouin lidar to remotely measure temperature profiles of the ocean , 2014 .

[111]  S. Dilhaire,et al.  All-optical broadband ultrasonography of single cells , 2015, Scientific Reports.

[112]  Vladislav V. Yakovlev,et al.  Probing microscopic mechanical properties of hard tissues with Brillouin spectroscopy , 2015, Photonics West - Biomedical Optics.

[113]  Carl Paterson,et al.  Elastic suppression in Brillouin imaging by destructive interference , 2015 .

[114]  Vladislav V. Yakovlev,et al.  Subcellular imaging of mechanical and chemical properties using Brillouin and Raman microspectroscopies , 2015, Photonics West - Biomedical Optics.

[115]  William J. Polacheck,et al.  Noncontact three-dimensional mapping of intracellular hydro-mechanical properties by Brillouin microscopy , 2015, Nature Methods.

[116]  Manish K Jaiswal,et al.  Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach. , 2015, ACS nano.

[117]  Motonobu Tomoda,et al.  Three-dimensional imaging of biological cells with picosecond ultrasonics , 2015 .

[118]  Vladislav V. Yakovlev,et al.  Brillouin spectroscopy characterizes microscopic viscoelasticity associated with skin injury , 2015, Photonics West - Biomedical Optics.

[119]  M. Clark,et al.  Thin-film optoacoustic transducers for subcellular Brillouin oscillation imaging of individual biological cells. , 2015, Applied optics.

[120]  Zhaokai Meng,et al.  Brillouin spectroscopy as a new method of screening for increased CSF total protein during bacterial meningitis , 2015, Journal of biophotonics.

[121]  Vladislav V. Yakovlev,et al.  High-speed assessment of liquid viscoelasticity in flow cytometry using nonlinear Brillouin spectroscopy , 2015, Photonics West - Biomedical Optics.

[122]  Vladislav V. Yakovlev,et al.  Atherosclerotic plaque detection by confocal Brillouin and Raman microscopies , 2015, Photonics West - Biomedical Optics.

[123]  Marlan O Scully,et al.  Dual Raman-Brillouin Microscope for Chemical and Mechanical Characterization and Imaging. , 2015, Analytical chemistry.

[124]  Vladislav V. Yakovlev,et al.  Stimulated Brillouin Scattering Microscopic Imaging , 2015, Scientific Reports.

[125]  Vladislav V. Yakovlev,et al.  Surface-enhanced Brillouin scattering in a vicinity of plasmonic gold nanostructures , 2015, Photonics West - Biomedical Optics.