Dual TNFα-Induced Effects on NRF2 Mediated Antioxidant Defence in Astrocyte-Rich Cultures: Role of Protein Kinase Activation

[1]  M. Nilsson,et al.  Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: Restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β , 2011, Neurobiology of Disease.

[2]  Fang Liu,et al.  Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. , 2011, Cellular signalling.

[3]  M. Nilsson,et al.  The Nrf2‐inducible antioxidant defense in astrocytes can be both up‐ and down‐regulated by activated microglia:Involvement of p38 MAPK , 2011, Glia.

[4]  H. Grossniklaus,et al.  Age-Related Retinopathy in NRF2-Deficient Mice , 2011, PloS one.

[5]  S. Niture,et al.  INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis , 2011, Cell Death and Differentiation.

[6]  P. Magistretti,et al.  Astrocyte–neuron metabolic relationships: for better and for worse , 2011, Trends in Neurosciences.

[7]  K. Abe,et al.  Expression of Keap1–Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion , 2011, Brain Research.

[8]  Stephen Dewhurst,et al.  Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via intraneuronal receptor crosstalk? , 2011, Journal of NeuroVirology.

[9]  Jianqi Yang,et al.  Acetylation-Deacetylation of the Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-related Factor 2) Regulates Its Transcriptional Activity and Nucleocytoplasmic Localization* , 2010, The Journal of Biological Chemistry.

[10]  B. Doble,et al.  Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci* , 2010, The Journal of Biological Chemistry.

[11]  C. Ahn,et al.  Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation. , 2010, Cellular signalling.

[12]  M. Morgan,et al.  Reactive oxygen species in TNFα-induced signaling and cell death , 2010, Molecules and cells.

[13]  D. Edelman,et al.  HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons , 2010, PloS one.

[14]  M. McMahon,et al.  p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription* , 2010, The Journal of Biological Chemistry.

[15]  C. Ferrari,et al.  Chronic expression of low levels of tumor necrosis factor-α in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation , 2010, Neurobiology of Disease.

[16]  H. J. Kim,et al.  Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. , 2010, American journal of physiology. Renal physiology.

[17]  M. Bonay,et al.  Prolonged cigarette smoke exposure decreases heme oxygenase‐1 and alters Nrf2 and Bach1 expression in human macrophages: Roles of the MAP kinases ERK1/2 and JNK , 2009, FEBS letters.

[18]  A. Kong,et al.  Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters. , 2009, Biopharmaceutics & drug disposition.

[19]  V. Vijayan,et al.  Inhibition and Genetic Deficiency of p38 MAPK Up-Regulates Heme Oxygenase-1 Gene Expression via Nrf21 , 2009, The Journal of Immunology.

[20]  M. Cuénod,et al.  Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit , 2009, Journal of neurochemistry.

[21]  T. Wieloch,et al.  Tumor Necrosis Factor Receptor-1 is Essential for LPS-Induced Sensitization and Tolerance to Oxygen—Glucose Deprivation in Murine Neonatal Organotypic Hippocampal Slices , 2009, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  DelindaA . Johnson,et al.  Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis , 2008, The Journal of Neuroscience.

[23]  M. Tansey,et al.  Journal of Neuroinflammation BioMed Central Review , 2008 .

[24]  M. L. de Ceballos,et al.  The Transcription Factor Nrf2 Is a Therapeutic Target against Brain Inflammation1 , 2008, The Journal of Immunology.

[25]  P. Magistretti,et al.  Modulation of astrocytic metabolic phenotype by proinflammatory cytokines , 2008, Glia.

[26]  Soo Young Lee,et al.  TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival. , 2008, Biochemical and biophysical research communications.

[27]  J. Qu,et al.  NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. , 2008, Biochimica et biophysica acta.

[28]  A. I. Rojo,et al.  GSK‐3β down‐regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress , 2008 .

[29]  I. Figiel.  Pro-inflammatory cytokine TNF-alpha as a neuroprotective agent in the brain. , 2008, Acta neurobiologiae experimentalis.

[30]  J. O'Callaghan,et al.  Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. , 2007, The American journal of pathology.

[31]  Changlian Zhu,et al.  N‐acetylcysteine reduces lipopolysaccharide‐sensitized hypoxic‐ischemic brain injury , 2007, Annals of neurology.

[32]  Jun Chen,et al.  Preconditioning Suppresses Inflammation in Neonatal Hypoxic Ischemia Via Akt Activation , 2007, Stroke.

[33]  L. Young,et al.  Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate , 2007, Neuroscience.

[34]  Shyam Biswal,et al.  Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. , 2007, Annual review of pharmacology and toxicology.

[35]  C. Glass,et al.  Expression of Nrf2 in Neurodegenerative Diseases , 2007, Journal of neuropathology and experimental neurology.

[36]  A. Kong,et al.  Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2 , 2006, Molecular Cancer Therapeutics.

[37]  A. I. Rojo,et al.  Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2* , 2006, Journal of Biological Chemistry.

[38]  R. N. Saha,et al.  Up-regulation of BDNF in Astrocytes by TNF-α: A Case for the Neuroprotective Role of Cytokine , 2006, Journal of Neuroimmune Pharmacology.

[39]  T. Murphy,et al.  A Small-Molecule-Inducible Nrf2-Mediated Antioxidant Response Provides Effective Prophylaxis against Cerebral Ischemia In Vivo , 2005, The Journal of Neuroscience.

[40]  Y. Zou,et al.  Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage. , 2005, The Biochemical journal.

[41]  Shelly C. Lu,et al.  Tumour necrosis factor α induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor κB and activator protein-1 , 2005 .

[42]  S. Tatebe,et al.  Delayed Mechanism for Induction of γ-Glutamylcysteine Synthetase Heavy Subunit mRNA Stability by Oxidative Stress Involving p38 Mitogen-activated Protein Kinase Signaling* , 2005, Journal of Biological Chemistry.

[43]  M. Nilsson,et al.  Gap junction blockage limits intercellular spreading of astrocytic apoptosis induced by metabolic depression , 2005, Journal of neurochemistry.

[44]  J. Jia,et al.  Cerebrospinal fluid tau, Aβ1–42 and inflammatory cytokines in patients with Alzheimer's disease and vascular dementia , 2005, Neuroscience Letters.

[45]  K. Takenaga,et al.  A procedure for culturing astrocytes from white matter and the application of the siRNA technique for silencing the expression of their specific marker, S100A4. , 2005, Brain research. Brain research protocols.

[46]  Yan Bai,et al.  Phosphorylation-Dependent Degradation of p300 by Doxorubicin-Activated p38 Mitogen-Activated Protein Kinase in Cardiac Cells , 2005, Molecular and Cellular Biology.

[47]  K. Blomgren,et al.  IGF‐I neuroprotection in the immature brain after hypoxia‐ischemia, involvement of Akt and GSK3β? , 2005, The European journal of neuroscience.

[48]  T. Murphy,et al.  Coordinate regulation of glutathione metabolism in astrocytes by Nrf2. , 2005, Biochemical and biophysical research communications.

[49]  Shelly C. Lu,et al.  Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. , 2005, The Biochemical journal.

[50]  J. Harper,et al.  The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase , 2004, Molecular and Cellular Biology.

[51]  Jiahuai Han,et al.  Regulation of Nrf2 Transactivation Domain Activity , 2004, Journal of Biological Chemistry.

[52]  R. Dringen,et al.  TNFα increases activity of γ‐glutamyl transpeptidase in cultured rat astroglial cells , 2004 .

[53]  E. Hansson.  Cellular composition of a cerebral hemisphere primary culture , 1984, Neurochemical Research.

[54]  K. Blennow,et al.  Cerebral pattern of pro- and anti-inflammatory cytokines in dementias , 2003, Brain Research Bulletin.

[55]  T. Murphy,et al.  Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress , 2003, The Journal of Neuroscience.

[56]  H. Schipper,et al.  Proinflammatory cytokines promote glial heme oxygenase‐1 expression and mitochondrial iron deposition: implications for multiple sclerosis , 2001, Journal of neurochemistry.

[57]  H. Lung,et al.  Induction of tumor necrosis factor receptor type 2 gene expression by tumor necrosis factor-alpha in rat primary astrocytes. , 2001, Life sciences.

[58]  Y. Mo,et al.  Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism* , 2000, The Journal of Biological Chemistry.

[59]  E. Eftekharpour,et al.  Thioredoxin reductase and glutathione synthesis is upregulated by t‐butylhydroquinone in cortical astrocytes but not in cortical neurons , 2000, Glia.

[60]  E. Alleva,et al.  Learning performances, brain NGF distribution and NPY levels in transgenic mice expressing TNF-alpha , 2000, Behavioural Brain Research.

[61]  R. Dringen,et al.  Synthesis of the Antioxidant Glutathione in Neurons: Supply by Astrocytes of CysGly as Precursor for Neuronal Glutathione , 1999, The Journal of Neuroscience.

[62]  M. Mattson,et al.  Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD , 1999, Journal of Neuroimmunology.

[63]  Mushfiquddin Khan,et al.  Cytokine-mediated Induction of Ceramide Production Is Redox-sensitive , 1998, The Journal of Biological Chemistry.

[64]  A. Colell,et al.  Tumor Necrosis Factor Increases Hepatocellular Glutathione by Transcriptional Regulation of the Heavy Subunit Chain of γ-Glutamylcysteine Synthetase* , 1997, The Journal of Biological Chemistry.

[65]  M. Mattson,et al.  Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis , 1994, Neuron.

[66]  T. Marunouchi,et al.  TNFα induces IL-6 production by astrocytes but not by microglia , 1992, Brain Research.

[67]  T. Marunouchi,et al.  TNF alpha induces IL-6 production by astrocytes but not by microglia. , 1992, Brain research.