Correlation between the charge of polymer particles in solution and in the gas phase investigated by zeta-potential measurements and electrospray ionization mass spectrometry.

The relationship between the effective charge of polymer nanoparticles (PNP) in solution and the charge states of ionized particles produced in the gas phase by electrospray ionization was investigated. Charge detection mass spectrometry was used to measure both the mass and charge of individual electrosprayed ions. The effective charges extracted from the measured zeta-potential of PNPs in solution are partially correlated with the average values of charge of PNPs in the gas phase. The correlation between the magnitude of charging of PNPs ions produced in the gas phase with the PNPs surface charge in solution demonstrates that the mass spectrometry-based analysis described in this work is an alternative and promising way for a fast and systematic characterization of charges on colloidal particles.

[1]  W. Cui,et al.  Fabrication and surface characterization of electrosprayed poly(L‐lactide) microspheres , 2013 .

[2]  S. A. McLuckey,et al.  Nondestructive tandem mass spectrometry using a linear quadrupole ion trap coupled to a linear electrostatic ion trap. , 2013, Analytical chemistry.

[3]  Kevin Braeckmans,et al.  Polymer-coated nanoparticles interacting with proteins and cells: focusing on the sign of the net charge. , 2013, ACS nano.

[4]  Teófilo Rojo,et al.  The challenge to relate the physicochemical properties of colloidal nanoparticles to their cytotoxicity. , 2013, Accounts of chemical research.

[5]  C. Haynes,et al.  Toxicity of engineered nanoparticles in the environment. , 2013, Analytical chemistry.

[6]  P. Dugourd,et al.  The charging of micellar nanoparticles in electrospray ionization. , 2013, Chemphyschem : a European journal of chemical physics and physical chemistry.

[7]  Patrick Couvreur,et al.  Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery. , 2013, Chemical Society reviews.

[8]  T. Nann,et al.  On the use of pH titration to quantitatively characterize colloidal nanoparticles. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[9]  L. Lagae,et al.  Measuring the electric charge and zeta potential of nanometer-sized objects using pyramidal-shaped nanopores. , 2012, Analytical Chemistry.

[10]  M. Trau,et al.  Simultaneous size and ζ-potential measurements of individual nanoparticles in dispersion using size-tunable pore sensors. , 2012, ACS nano.

[11]  H. Ohshima,et al.  Determination of effective charge of small ions, polyelectrolytes and nanoparticles by capillary electrophoresis. , 2012, Journal of chromatography. A.

[12]  Warren C W Chan,et al.  The effect of nanoparticle size, shape, and surface chemistry on biological systems. , 2012, Annual review of biomedical engineering.

[13]  R. Hill,et al.  Nanoparticle ζ -potentials. , 2012, Accounts of chemical research.

[14]  Subinoy Rana,et al.  Surface functionalization of nanoparticles for nanomedicine. , 2012, Chemical Society reviews.

[15]  P. Dugourd,et al.  Direct Molar Mass Determination of Self-Assembled Amphiphilic Block Copolymer Nanoobjects Using Electrospray-Charge Detection Mass Spectrometry. , 2012, ACS macro letters.

[16]  A. Elaissari,et al.  Electrokinetic properties of bare or nanoparticle-functionalized textile fabrics , 2012 .

[17]  Z. Adamczyk,et al.  Colloid particle and protein deposition - electrokinetic studies. , 2011, Advances in colloid and interface science.

[18]  P. Dugourd,et al.  Infrared multiphoton dissociation tandem charge detection-mass spectrometry of single megadalton electrosprayed ions. , 2011, The Review of scientific instruments.

[19]  P. Dugourd,et al.  Charging megadalton poly(ethylene oxide)s by electrospray ionization. A charge detection mass spectrometry study. , 2011, Rapid Communications in Mass Spectrometry.

[20]  Tim R. Dargaville,et al.  Electrospraying, a Reproducible Method for Production of Polymeric Microspheres for Biomedical Applications , 2011 .

[21]  H. Ohshima,et al.  Electrophoretic mobility of a colloidal particle with constant surface charge density. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[22]  P. Biswas,et al.  Role of the effective electrical conductivity of nanosuspensions in the generation of TiO2 agglomerates with electrospray , 2010 .

[23]  Oğuz Balci,et al.  Size controlled synthesis of sub-100 nm monodisperse poly(methylmethacrylate) nanoparticles using surfactant-free emulsion polymerization. , 2010, Journal of colloid and interface science.

[24]  P. Kebarle,et al.  Electrospray: from ions in solution to ions in the gas phase, what we know now. , 2009, Mass spectrometry reviews.

[25]  M. Eslamian,et al.  Recent advances in nanoparticle preparation by spray and micro-emulsion methods. , 2009, Recent patents on nanotechnology.

[26]  H. Ohshima,et al.  Electrophoretic mobility of colloidal gold particles in electrolyte solutions. , 2009, Langmuir : the ACS journal of surfaces and colloids.

[27]  Christopher J. Hogan,et al.  Charged droplet dynamics in the submicrometer size range. , 2009, The journal of physical chemistry. B.

[28]  A. T. Sobczyk,et al.  Electrospraying route to nanotechnology: An overview , 2008 .

[29]  A. Aksenov,et al.  The analysis of polystyrene and polystyrene aggregates into the mega dalton mass range by cryodetection MALDI TOF MS , 2008, Journal of the American Society for Mass Spectrometry.

[30]  B. Nowack,et al.  Occurrence, behavior and effects of nanoparticles in the environment. , 2007, Environmental pollution.

[31]  Bangwoo Han,et al.  Highly charging of nanoparticles through electrospray of nanoparticle suspension. , 2005, Journal of colloid and interface science.

[32]  R. J. Hunter,et al.  Measurement and Interpretation of Electrokinetic Phenomena (IUPAC Technical Report) , 2005 .

[33]  Aimin Zhang,et al.  Poly(methyl methacrylate) nanoparticles prepared through microwave emulsion polymerization , 2004 .

[34]  H. Girault,et al.  Electrochemical and theoretical aspects of electrospray ionisation , 2004 .

[35]  Kikuo Okuyama,et al.  Preparation of nanoparticles via spray route , 2003 .

[36]  Bin Xia,et al.  Sizing of Colloidal Nanoparticles by Electrospray and Differential Mobility Analyzer Methods , 2002 .

[37]  H. Ohshima.  Approximate Analytic Expression for the Electrophoretic Mobility of a Spherical Colloidal Particle. , 2001, Journal of colloid and interface science.

[38]  G. Siuzdak,et al.  Mass Spectrometry of an Intact Virus. , 2001, Angewandte Chemie.

[39]  M. Borkovec,et al.  Charging and Aggregation Properties of Carboxyl Latex Particles: Experiments versus DLVO Theory , 2000 .

[40]  Richard D. Smith,et al.  Correlation between the Charge of Proteins in Solution and in the Gas Phase Investigated by Protein Charge Ladders, Capillary Electrophoresis, and Electrospray Ionization Mass Spectrometry , 1998 .

[41]  J. C. Schultz,et al.  Mass determination of megadalton-DNA electrospray ions using charge detection mass spectrometry , 1998, Journal of the American Society for Mass Spectrometry.

[42]  Richard D. Smith,et al.  Trapping, Detection, and Mass Determination of Coliphage T4 DNA Ions by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry , 1995 .

[43]  Hiroyuki Ohshima,et al.  Accurate analytic expressions for the surface charge density/surface potential relationship and double-layer potential distribution for a spherical colloidal particle , 1982 .

[44]  A. L. Loeb,et al.  The electrical double layer around a spherical colloid particle , 1961 .

[45]  M. Jarrold,et al.  Charge Detection Mass Spectrometry with Resolved Charge States , 2012, Journal of The American Society for Mass Spectrometry.

[46]  K. Okuyama,et al.  Preparation of ZnS Nanoparticles by Electrospray Pyrolysis , 2000 .

[47]  W. H. Benner,et al.  Molecular weight determination of megadalton DNA electrospray ions using charge detection time-of-flight mass spectrometry. , 1995, Rapid communications in mass spectrometry : RCM.

[48]  R. J. Hunter.  Zeta potential in colloid science : principles and applications , 1981 .

[49]  L. White.  Approximate analytic solution of the Poisson–Boltzmann equation for a spherical colloidal particle , 1977 .