Quiescent stem cells in the niche

Quiescence of stem cells is critical to ensure lifelong tissue maintenance and to protect the stem cell pool from premature exhaustion under conditions of various stresses. The long-term maintenance of stem cells largely depends on the interaction with their specific microenvironments, niches. Detailed studies in recent years elucidated that the interaction of stem cells with their specialized microenvironment “niche” is critical to sustain stem cell pools in tissues over long periods and that the stem cell niche regulates stem cell-specific properties, including self-renewal, multi-potentiality, and relative quiescence in cell cycle. Here we discuss quiescent stem cells in the adult hematopoietic system and describe the regulatory mechanisms of hematopoietic stem cell (HSC) quiescence in bone marrow. Niches for HSCs have been identified in the endosteal region “osteoblastic niche” and a perivascular area “vascular niche”. Although the functional differences of these two niches still need to be investigated, HSCs are maintained via a complex interaction of cells, cytokines, adhesion molecules, and extracellular matrix. Quiescent stem cells in the hypoxic niche might be sensitive to reactive oxygen species (ROS) and show glycolysis-dependent metabolism.

[1]  T. Suda,et al.  Wnt Signaling in the Niche , 2008, Cell.

[2]  I. Weissman,et al.  Stems Cells and the Pathways to Aging and Cancer , 2008, Cell.

[3]  Sean J. Morrison,et al.  Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life , 2008, Cell.

[4]  T. Suda,et al.  Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. , 2008, Biochemical and biophysical research communications.

[5]  Lina A. Thoren,et al.  Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. , 2007, Cell stem cell.

[6]  T. Suda,et al.  Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. , 2007, Cell stem cell.

[7]  Keisuke Ito,et al.  Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction. , 2007, Biochemical and biophysical research communications.

[8]  I. Weissman,et al.  Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches , 2007, Science.

[9]  Xi C. He,et al.  N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells. , 2007, Cell stem cell.

[10]  B. Sacchetti,et al.  Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment , 2007, Cell.

[11]  S. Sharkis,et al.  A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. , 2007, Blood.

[12]  I. Weissman,et al.  Hematopoietic Stem Cell Quiescence Attenuates DNA Damage Response and Permits DNA Damage Accumulation During Aging , 2007, Cell cycle.

[13]  Shenghui He,et al.  Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU , 2007, Nature.

[14]  S. Morrison,et al.  Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. , 2007, Cell stem cell.

[15]  S. Nishikawa,et al.  Generating quiescent stem cells. , 2007, Pigment cell research.

[16]  S. Orkin,et al.  Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment , 2007, Cell.

[17]  Irving L. Weissman,et al.  Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age , 2007, Nature.

[18]  H. Nakauchi,et al.  Foxo3a is essential for maintenance of the hematopoietic stem cell pool. , 2007, Cell stem cell.

[19]  P. Chambon,et al.  A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency , 2007, Cell.

[20]  D. Bonnet,et al.  Age‐Dependent Increase in Side Population Distribution Within Hematopoiesis: Implications for Our Understanding of the Mechanism of Aging , 2007, Stem cells.

[21]  S. Armstrong,et al.  FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress , 2007, Cell.

[22]  T. Nagasawa,et al.  Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. , 2006, Immunity.

[23]  B. Porse,et al.  Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block , 2006, Nature Immunology.

[24]  A. Iwama,et al.  Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells , 2006, The EMBO journal.

[25]  Linheng Li,et al.  The stem cell niches in bone. , 2006, The Journal of clinical investigation.

[26]  Keisuke Ito,et al.  Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells , 2006, Nature Medicine.

[27]  B. Williams,et al.  Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells. , 2005, Blood.

[28]  T. Suda,et al.  Hematopoietic stem cells and their niche. , 2005, Trends in immunology.

[29]  S. Morrison,et al.  Supplemental Experimental Procedures , 2022 .

[30]  Y. Ko,et al.  Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size , 2005, The Journal of experimental medicine.

[31]  Mark J. Murphy,et al.  c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. , 2004, Genes & development.

[32]  Tak W. Mak,et al.  Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells , 2004, Nature.

[33]  Keisuke Ito,et al.  Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche , 2004, Cell.

[34]  D. Rowe,et al.  Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. , 2004, Blood.

[35]  E. Fuchs,et al.  Socializing with the Neighbors Stem Cells and Their Niche , 2004, Cell.

[36]  E. Fuchs,et al.  Defining the Epithelial Stem Cell Niche in Skin , 2004, Science.

[37]  Haiyang Huang,et al.  Identification of the haematopoietic stem cell niche and control of the niche size , 2003, Nature.

[38]  D. Scadden,et al.  Osteoblastic cells regulate the haematopoietic stem cell niche , 2003, Nature.

[39]  A. Bernstein,et al.  Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  M. Fuller,et al.  Orientation of Asymmetric Stem Cell Division by the APC Tumor Suppressor and Centrosome , 2003, Science.

[41]  I. Weissman,et al.  Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. , 2003, Blood.

[42]  I. Weissman,et al.  A role for Wnt signalling in self-renewal of haematopoietic stem cells , 2003, Nature.

[43]  G. Spangrude,et al.  Major Age‐Related Changes Of Mouse Hematopoietic Stem/Progenitor Cells , 2003, Annals of the New York Academy of Sciences.

[44]  Gary Ruvkun,et al.  DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism , 2003, Science.

[45]  John T. Dimos,et al.  A Stem Cell Molecular Signature , 2002, Science.

[46]  D. Melton,et al.  "Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells , 2002, Science.

[47]  Christopher S Potten,et al.  Intestinal stem cells protect their genome by selective segregation of template DNA strands. , 2002, Journal of cell science.

[48]  S. Rafii,et al.  Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand , 2002, Cell.

[49]  A. Boyd,et al.  Functional heterogeneity within rhodamine123(lo) Hoechst33342(lo/sp) primitive hemopoietic stem cells revealed by pyronin Y. , 2001, Experimental hematology.

[50]  H. Nakauchi,et al.  The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype , 2001, Nature Medicine.

[51]  Yann Barrandon,et al.  Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells , 2001, Cell.

[52]  D. Scadden,et al.  Hematopoietic stem cell quiescence maintained by p21cip1/waf1. , 2000, Science.

[53]  Kindred A. Ritchie,et al.  Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietin. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[54]  I. Weissman,et al.  In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[55]  G. Yancopoulos,et al.  Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. , 1998, Immunity.

[56]  A. Roberts,et al.  Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[57]  B. Williams,et al.  Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment. , 1997, Experimental hematology.

[58]  Pamela F. Jones,et al.  Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning , 1996, Cell.

[59]  J. Rossant,et al.  Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development. , 1996, Development.

[60]  I. Weissman,et al.  The aging of hematopoietic stem cells , 1996, Nature Medicine.

[61]  H. Broxmeyer,et al.  Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. , 1996, Blood.

[62]  A. S. Conner,et al.  Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo , 1996, The Journal of experimental medicine.

[63]  W S Alexander,et al.  Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. , 1996, Blood.

[64]  T. Sato,et al.  Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells. , 1996, Oncogene.

[65]  D L Riddle,et al.  The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. , 1984, Developmental biology.

[66]  R. G. Eagon,et al.  Factors Affecting the Pathways of Glucose Catabolism and the Tricarboxylic Acid Cycle in Pseudomonas natriegens , 1967, Journal of bacteriology.

[67]  宮本 佳奈.  Foxo3a is essential for maintenance of the hematopoietic stem cell pool , 2007 .

[68]  H. Clevers.  Wnt/beta-catenin signaling in development and disease. , 2006, Cell.

[69]  F. Rosenbauer,et al.  Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. , 2006, Nature immunology.

[70]  R. Schofield.  The relationship between the spleen colony-forming cell and the haemopoietic stem cell. , 1978, Blood cells.