INHIBITION OF CALCIUM OXALATE CRYSTALLIZATION IN VITRO BY EXTRACT OF BANANA CULTIVAR MONTHAN

Objective: To study the effect of banana cultivar Monthan corm extract for its antilithiatic potential under in vitro condition. Methods: Banana cultivar Monthan corm extracts of different solvents with varying polarity were tested for its antilithiatic potential. Kidney stone formation was studied under in vitro conditions using three critical assays such as crystal nucleation, aggregation and growth. The effect of extract on the formation and inhibition of crystals were observed spectrophotometrically and the results were presented in this paper. Results: The results of the in vitro assays performed indicate that ethanol extract of Monthan readily prevented crystal nucleation, growth and aggregation. Conclusion: Monthan corm juice is found to be an effective diuretic, and act as a promoter for inhibitors of crystallization.

[1]  Saeed R. Khan,et al.  Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica , 2012, Urological Research.

[2]  V. Chitra,et al.  ANTILITHIATIC ACTIVITY OF ALCOHOLIC EXTRACT OF BOERHAAVIA DIFFUSA ROOTS ON ETHYLENE GLYCOL INDUCED LITHIASIS IN RATS , 2012 .

[3]  Prasobh Gr.  Effect of MUSA Tablet on Ethylene Glycol-Induced Urolithiasis in Rats , 2012 .

[4]  R. Harwansh,et al.  In-vitro calcium oxalate crystallization inhibition by achyranthes indica linn. Hydroalcoholic extract: an approach to antilithiasis , 2011 .

[5]  C. Tandon,et al.  Diminution of oxalate induced renal tubular epithelial cell injury and inhibition of calcium oxalate crystallization in vitro by aqueous extract of Tribulus terrestris. , 2010, International braz j urol : official journal of the Brazilian Society of Urology.

[6]  K. Pachana,et al.  Application of small caltrops (Tribulus terrestris) to inhibit calcium oxalate monohydrate crystallization , 2010 .

[7]  V. Butterweck,et al.  Herbal medicines in the management of urolithiasis: alternative or complementary? , 2009, Planta medica.

[8]  D. Goli,et al.  DIURETIC ACTIVITY OF ROOT EXTRACT OF RUBIA CORDIFOLIA LINN. , 2009 .

[9]  P. Rai,et al.  Assessment of glycemic potential ofMusa paradisiaca stem juice , 2007, Indian Journal of Clinical Biochemistry.

[10]  M. Khullar,et al.  Lithogenesis: induction of renal calcifications by nanobacteria , 2006, Urological Research.

[11]  A. Hesse.  Reliable data from diverse regions of the world exist to show that there has been a steady increase in the prevalence of urolithiasis. , 2005, World journal of urology.

[12]  M. Daudon,et al.  A new approach to studying inhibitors of calcium oxalate crystal growth , 1993, Urological Research.

[13]  S. Sathiamoorthy,et al.  Evaluation of commercial cultivars of banana (Musa) for their suitability for the fibre industry , 2005 .

[14]  M. E. Barros,et al.  Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro , 2003, Urological Research.

[15]  C. Pak,et al.  Effect of diphosphonate on crystallization of calcium oxalate in vitro. , 1975, Kidney international.