A ROLE OF TRANEXAMIC ACID IN REDUCING BLOOD LOSS IN NORMAL LABOUR

Background: Though labour is a physiological process it is associated with maternal morbidity and mortality. A life-threatening obstetric hemorrhage occurs in around 1 in 1000 deliveries. Efforts to prevent and minimize maternal morbidity and death related to PPH may help to close the gap in maternal health outcomes that exists throughout the world. Thus, this study was aimed to determine the efficacy of Tranexamic acid in reducing post-partum blood loss after normal vaginal delivery. The changes in the fibrinolytic components during and immediately after placental delivery are consistent with fibrinolysis which occurs as a response to local fibrin deposition which in turn occurs as a result of tisssue damage. Hence there occurs a decrease in fibrinogen level and increase in fibrinogen degradation products. Tranexamic acid is a Competitive inhibitor of plasminogen activator.It prevents Fibrin degradation & preserving the framework of fibrin matrix structure. Hence Tranexamic acid, an anti fibrinolytic agent is used to reduce blood loss after normal delivery with an aim to decrease the incidence of excessive blood loss after delivery. Materials and Methods: This study is conducted among patients admitted in labour ward of Government Villupuram Medical College and Hospital for normal vaginal delivery.Study population are divided into 2 groups as follows, each having 60. The study group and the control group are treated as per Standard AMTSL protocol with along with Inj. Tranexamic acid 1gm iv infusion in 100 ml NS over 15 minutes period after delivery of baby in study group alone. In each case, the parameters like pre delivery