Terahertz time-domain spectroscopy of chondroitin sulfate.

Chondroitin sulfate (CS), derived from cartilage tissues, is an important type of biomacromolecule. In this paper, the terahertz time-domain spectroscopy (THz-TDS) was investigated as a potential method for content detection of CS. With the increase of the CS content, the THz absorption coefficients of the CS/polyethylene mixed samples linearly increase. The refractive indices of the mixed samples also increase when the CS content increases. The extinction coefficient of CS demonstrates the THz frequency dependence to be approximately the power of 1.4, which can be explained by the effects of CS granular solids on THz scattering.

[1]  A. Poole,et al.  Composition and structure of articular cartilage: a template for tissue repair. , 2001, Clinical orthopaedics and related research.

[2]  J. Reginster,et al.  Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. , 2009, Arthritis and rheumatism.

[3]  Robert M Lauder,et al.  Chondroitin sulphate: a complex molecule with potential impacts on a wide range of biological systems. , 2009, Complementary therapies in medicine.

[4]  J. Coutaz,et al.  Highly precise determination of optical constants and sample thickness in terahertz time-domain spectroscopy. , 1999, Applied optics.

[5]  T. Uhl,et al.  A review of articular cartilage pathology and the use of glucosamine sulfate. , 2001, Journal of athletic training.

[6]  H. Kitagawa,et al.  Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate. , 2003, Current opinion in structural biology.

[7]  W. Brown,et al.  Analysis by high-performance liquid chromatography of hyaluronic acid and chondroitin sulfates. , 1986, Analytical biochemistry.

[8]  Shi-Yu Huang,et al.  [Comparative studies on the characteristics of the Fourier-transform infrared spectra between sturgeon and shark chondroitin sulfates]. , 2008, Guang pu xue yu guang pu fen xi = Guang pu.

[9]  Richard Baraniuk,et al.  Material parameter estimation with terahertz time-domain spectroscopy. , 2001, Journal of the Optical Society of America. A, Optics, image science, and vision.

[10]  Daniel M Mittleman,et al.  Scale model experimentation: using terahertz pulses to study light scattering. , 2002, Physics in medicine and biology.

[11]  N. Volpi.  Quality of different chondroitin sulfate preparations in relation to their therapeutic activity , 2009 .

[12]  Zhao-hui Zhang,et al.  [Extracting THz absorption coefficient spectrum based on accurate determination of sample thickness]. , 2012, Guang pu xue yu guang pu fen xi = Guang pu.

[13]  B. Fischer,et al.  Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy. , 2002, Biopolymers.

[14]  E. Vignon,et al.  Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. , 2004, Osteoarthritis and cartilage.