T-cell receptor ligation by peptide / MHC induces activation of a caspase in immature thymocytes : the molecular basis of negative selection generally involves thymocytes at the DP stage of

generally involves thymocytes at the DP stage of Linda K.Clayton1,3,7, Yoseph Ghendler1,3, development. Emiko Mizoguchi2,4, Raymond J.Patch5, Although the mechanism of negative selection is Timothy D.Ocain5, Kim Orth6, unknown, the targeted thymocytes die via apoptosis Atul K.Bhan2,4, Vishva M.Dixit6 and (Murphy et al., 1990), a physiologically controlled form Ellis L.Reinherz1,3 of cell death utilized by metazoan organisms during normal

[1]  Junying Yuan,et al.  Human ICE/CED-3 Protease Nomenclature , 1996, Cell.

[2]  Junying Yuan,et al.  Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE* , 1996, The Journal of Biological Chemistry.

[3]  S. Korsmeyer,et al.  Molecular thanatopsis: a discourse on the BCL2 family and cell death. , 1996, Blood.

[4]  Matthias Mann,et al.  FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex , 1996, Cell.

[5]  D. Vaux,et al.  The molecular biology of apoptosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  P. Henkart.  ICE family proteases: mediators of all apoptotic cell death? , 1996, Immunity.

[7]  H. Griesser,et al.  Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice , 1996, Cell.

[8]  A. Chinnaiyan,et al.  ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[9]  Muneesh Tewari,et al.  Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase , 1995, Cell.

[10]  H. Steller.  Mechanisms and genes of cellular suicide , 1995, Science.

[11]  R. Kamen,et al.  Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock , 1995, Cell.

[12]  C. Nalin.  Apoptosis research enters the ICE age. , 1995, Structure.

[13]  J. Sprent,et al.  T-cell apoptosis detected in situ during positive and negative selection in the thymus , 1994, Nature.

[14]  K. Schooley,et al.  Regulation of apoptosis and T cell activation by Fas-specific mAb. , 1994, International immunology.

[15]  J. Mankovich,et al.  Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer , 1994, Cell.

[16]  P. Griffin,et al.  Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones. , 1994, Biochemistry.

[17]  R. Eisenberg,et al.  Development of the T cell receptor repertoire in lpr mice. , 1994, Seminars in immunology.

[18]  L. Tartaglia,et al.  A novel domain within the 55 kd TNF receptor signals cell death , 1993, Cell.

[19]  D. Vaux.  Toward an understanding of the molecular mechanisms of physiological cell death. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[20]  I. Weissman,et al.  Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing. , 1992, International immunology.

[21]  K. Chapman.  Synthesis of a potent, reversible inhibitor of interleukin-1β converting enzyme , 1992 .

[22]  S. Hedrick,et al.  In vivo and in vitro clonal deletion of double-positive thymocytes , 1992, The Journal of experimental medicine.

[23]  K. O. Elliston,et al.  A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes , 1992, Nature.

[24]  V. Stewart,et al.  RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement , 1992, Cell.

[25]  J. Weidner,et al.  IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha. , 1991, Journal of immunology.

[26]  P. Möller,et al.  Monoclonal antibody-mediated tumor regression by induction of apoptosis. , 1989, Science.

[27]  S. Yonehara,et al.  A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor , 1989, The Journal of experimental medicine.

[28]  J. Sprent,et al.  T Cell Selection in the Thymus , 1988, Immunological reviews.

[29]  A. Wyllie.  Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation , 1980, Nature.

[30]  Filipponi,et al.  Evidence for , 1996, Physical review. B, Condensed matter.

[31]  J. Bluestone.  New perspectives of CD28-B7-mediated T cell costimulation. , 1995, Immunity.