Percutaneous absorption and metabolism of [14C]-ethoxycoumarin in a pig ear skin model.

[1]  H Frederick Frasch,et al.  Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review. , 2009, Toxicology in vitro : an international journal published in association with BIBRA.

[2]  A. Mavon,et al.  Caspase‐3 Activation and DNA Damage in Pig Skin Organ Culture After Solar Irradiation , 2008, Photochemistry and photobiology.

[3]  Sue Gibbs,et al.  Xenobiotic metabolism in human skin and 3D human skin reconstructs: a review. , 2007, Current drug metabolism.

[4]  Juergen Lademann,et al.  Porcine ear skin: an in vitro model for human skin , 2007, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[5]  Robert Landsiedel,et al.  Drug-Metabolizing Enzymes in the Skin of Man, Rat, and Pig , 2007, Drug metabolism reviews.

[6]  J. Lademann,et al.  Penetration studies of topically applied substances: Optical determination of the amount of stratum corneum removed by tape stripping. , 2006, Journal of biomedical optics.

[7]  N. Monteiro-Riviere,et al.  Dermatotoxicity of Cutting Fluid Mixtures:In Vitro and In Vivo Studies , 2006, Cutaneous and ocular toxicology.

[8]  U. Losert,et al.  Introducing the concept of the 3Rs into tissue engineering research. , 2006, ALTEX.

[9]  D. Bissett,et al.  Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin 1 , 2005, International journal of cosmetic science.

[10]  Rajeev Sharma,et al.  Surgical pearl: the safety pin as a better alternative to the versatile paper clip comedo extractor , 2004, International journal of dermatology.

[11]  A. Mavon,et al.  Skin absorption and metabolism of a new vitamin E prodrug, delta-tocopherol-glucoside: in vitro evaluation in human skin models. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[12]  J. Abel,et al.  Molecular pathways in dermatotoxicology. , 2004, Toxicology and applied pharmacology.

[13]  J. Marty,et al.  Characterization of the barrier function in a reconstituted human epidermis cultivated in chemically defined medium , 2002, International journal of cosmetic science.

[14]  P. Olinga,et al.  Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices , 2002, Xenobiotica; the fate of foreign compounds in biological systems.

[15]  Coenraad F M Hendriksen,et al.  Refinement, reduction, and replacement of animal use for regulatory testing: current best scientific practices for the evaluation of safety and potency of biologicals. , 2002, ILAR journal.

[16]  S. Penco,et al.  Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544. , 2001, Toxicology in vitro : an international journal published in association with BIBRA.

[17]  G. B. V. Beijersbergen van Henegouwen,et al.  Time and Dose-related Ultraviolet B Damage in Viable Pig Skin Explants Held in a Newly Developed Organ Culture System¶ , 2001, Photochemistry and photobiology.

[18]  J. J. van de Sandt,et al.  Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[19]  J. Cravedi,et al.  Metabolism of 4-hydroxynonenal, a cytotoxic product of lipid peroxidation, in rat precision-cut liver slices. , 2000, Toxicology letters.

[20]  C. F. Duffy,et al.  Determination of 7-hydroxycoumarin and its glucuronide and sulphate conjugates in liver slice incubates by capillary zone electrophoresis. , 1998, Journal of pharmaceutical and biomedical analysis.

[21]  J. Houston,et al.  In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes. , 1998, Drug metabolism and disposition: the biological fate of chemicals.

[22]  S. Hotchkiss,et al.  Comparativein VitroSkin Absorption and Metabolism of Coumarin (1,2-Benzopyrone) in Human, Rat, and Mouse , 1997 .

[23]  S. Hotchkiss,et al.  Comparative in vitro skin absorption and metabolism of coumarin (1,2-benzopyrone) in human, rat, and mouse. , 1997, Toxicology and applied pharmacology.

[24]  S. Ekins,et al.  Xenobiotic metabolism in rat, dog, and human precision-cut liver slices, freshly isolated hepatocytes, and vitrified precision-cut liver slices. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[25]  J. Scatina,et al.  [14C]7-ethoxycoumarin metabolism by precision-cut rat hepatic slices. , 1996, Drug metabolism and disposition: the biological fate of chemicals.

[26]  S. Ekins,et al.  Quantitative differences in phase I and II metabolism between rat precision-cut liver slices and isolated hepatocytes. , 1995, Drug metabolism and disposition: the biological fate of chemicals.

[27]  C. Cohen,et al.  The use of a reconstructed human epidermis episkin for the assessment of safety and efficacy of cosmetic products : In vitro approaches to contact dermatitis , 1995 .

[28]  D. G. Walters,et al.  Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices. , 1994, Xenobiotica; the fate of foreign compounds in biological systems.

[29]  R. Roguet,et al.  Measurement and modulation of cytochrome-P450-dependent enzyme activity in cultured human keratinocytes. , 1994, Skin pharmacology : the official journal of the Skin Pharmacology Society.

[30]  C. Filaquier,et al.  [Skin metabolism]. , 1992, Pathologie-biologie.

[31]  R. Bronaugh,et al.  Metabolism of xenobiotics during percutaneous penetration: role of absorption rate and cutaneous enzyme activity. , 1990, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[32]  G. Siest,et al.  Characterization of distinct forms of cytochromes P-450, epoxide metabolizing enzymes and UDP-glucuronosyltransferases in rat skin. , 1989, Biochemical pharmacology.

[33]  H. Mukhtar,et al.  Epidermal cytochrome P-450: immunochemical characterization of isoform induced by topical application of 3-methylcholanthrene to neonatal rat. , 1989, The Journal of pharmacology and experimental therapeutics.

[34]  S. Loft,et al.  Metabolism of metronidazole and antipyrine in isolated rat hepatocytes. Influence of sex and enzyme induction and inhibition. , 1989, Biochemical pharmacology.

[35]  S. Shuster,et al.  Distribution and sub‐cellular localization of drug metabolizing enzymes in the skin , 1985, The British journal of dermatology.

[36]  S. Shuster,et al.  Phase 1 and Phase 2 drug metabolism in isolated epidermal cells from adult hairless mice and in whole human hair follicles. , 1985, Biochemical pharmacology.

[37]  J. Fouts,et al.  Oxidation of 7-ethoxycoumarin and conjugation of umbelliferone by intact, viable epidermal cells from the hairless mouse. , 1984, The Journal of investigative dermatology.

[38]  J. Bridges,et al.  The metabolism of 7-ethoxycoumarin and 7-hydroxycoumarin by rat and hairless mouse skin strips. , 1982, Biochemical pharmacology.

[39]  J. Bridges,et al.  Cytochrome P-450 dependent deethylase activity in rat and hairless mouse skin microsomes. , 1982, Biochemical pharmacology.

[40]  P. Mier,et al.  CYTOCHROME P‐450‐DEPENDENT O‐DEALKYLASE ACTIVITY IN MAMMALIAN SKIN , 1982, British journal of pharmacology.

[41]  H. Mukhtar,et al.  Epidermis: a site of drug metabolism in neonatal rat skin. Studies on cytochrome P-450 content and mixed-function oxidase and epoxide hydrolase activity. , 1982, Molecular pharmacology.