Methicillin-Resistant Staphylococcus aureus (MRSA): A Briefing for Acute Care Hospitals and Nursing Facilities

The incidence of methicillin-resistant Staphylococcus aureus (MRSA) has increased in communities and in healthcare facilities in the United States since the mid-1970s. Although MRSA often is thought of as a nosocomial infection problem because it is encountered in facilities of all types and sizes, it also causes many community-acquired infections. Approaches to control of MRSA vary widely, and there is lack of agreement on the most appropriate measures to control MRSA in healthcare facilities. The wide variation in approaches is due, in part, to the lack of data establishing the efficacy of specific control measures. As a result, the approaches that have been advocated have resulted in confusing and often conflicting recommendations and control measures. In some settings, there also have been unreasonable barriers and administrative hurdles that delay or prevent the transfer of patients between acute care and nursing (extended care) facilities.

[1]  J. Boyce Methicillin-Resistant Staphylococcus aureus in Hospitals and Long-Term Care Facilities: Microbiology, Epidemiology, and Preventive Measures , 1992, Infection Control & Hospital Epidemiology.

[2]  W J Martone,et al.  Methicillin-resistant Staphylococcus aureus in U.S. hospitals, 1975-1991. , 1992, Infection control and hospital epidemiology.

[3]  L. Strausbaugh,et al.  Antimicrobial Therapy for Methicillin-Resistant Staphylococcus aureus Colonization in Residents and Staff of a Veterans Affairs Nursing Home Care Unit , 1992, Infection Control & Hospital Epidemiology.

[4]  J. Gerberding,et al.  Comparison of conventional susceptibility tests with direct detection of penicillin-binding protein 2a in borderline oxacillin-resistant strains of Staphylococcus aureus , 1991, Antimicrobial Agents and Chemotherapy.

[5]  R N Jones,et al.  Methicillin-resistant Staphylococcus aureus: implications for the 1990s and effective control measures. , 1991, The American journal of medicine.

[6]  M. Terpenning,et al.  Methicillin-resistant Staphylococcus aureus: colonization and infection in a long-term care facility. , 1991, Annals of internal medicine.

[7]  J. Miller,et al.  Methicillin-resistant staphylococcal colonization and infection in a long-term care facility. , 1991, Annals of internal medicine.

[8]  J. Boyce Should We Vigorously Try to Contain and Control Methicillin-Resistant Staphylococcus aureus? , 1991, Infection Control & Hospital Epidemiology.

[9]  R. Arbeit,et al.  Epidemiologic and clinical utility of typing systems for differentiating among strains of methicillin-resistant Staphylococcus aureus. , 1991 .

[10]  J. Jorgensen Mechanisms of methicillin resistance in Staphylococcus aureus and methods for laboratory detection. , 1991, Infection control and hospital epidemiology.

[11]  J. Boyce Increasing Prevalence of Methicillin-Resistant Staphylococcus aureus in the United States , 1990, Infection Control & Hospital Epidemiology.

[12]  G. Duckworth,et al.  Adherence and survival properties of an epidemic methicillin-resistant strain of Staphylococcus aureus compared with those of methicillin-sensitive strains. , 1990, Journal of medical microbiology.

[13]  A. Cheng,et al.  Hong Kong strains of methicillin-resistant and methicillin-sensitive Staphylococcus aureus have similar virulence. , 1990, The Journal of hospital infection.

[14]  G. Duckworth,et al.  Production of "virulence factors" by "epidemic" methicillin-resistant Staphylococcus aureus in vitro. , 1989, Journal of medical microbiology.

[15]  A. Mason,et al.  What's in a name? Is methicillin-resistant Staphylococcus aureus just another S aureus when treated with vancomycin? , 1989, Archives of surgery.

[16]  C. Hackbarth,et al.  Methicillin-resistant staphylococci: genetics and mechanisms of resistance , 1989, Antimicrobial Agents and Chemotherapy.

[17]  G. Archer,et al.  Comparison of epidemiological markers used in the investigation of an outbreak of methicillin-resistant Staphylococcus aureus infections , 1983, Journal of clinical microbiology.

[18]  R. Wenzel,et al.  Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus. , 1982, Annals of internal medicine.

[19]  J. Hughes,et al.  The emergence of methicillin-resistant Staphylococcus aureus infections in United States hospitals. Possible role of the house staff-patient transfer circuit. , 1982, Annals of internal medicine.

[20]  R. Wenzel,et al.  Methicillin-resistant Staphylococcus aureus: microbiologic characteristics, antimicrobial susceptibilities, and assessment of virulence of an epidemic strain. , 1981, The Journal of infectious diseases.