Peering into molecular mechanisms of action with frogSCOPE.

[1]  N. Veldhoen,et al.  Nanometals induce stress and alter thyroid hormone action in amphibia at or below North American water quality guidelines. , 2010, Environmental science & technology.

[2]  C. Helbing,et al.  C‐fin: A cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone‐disrupting chemicals , 2010, Environmental toxicology and chemistry.

[3]  Yunbo Shi Dual functions of thyroid hormone receptors in vertebrate development: the roles of histone-modifying cofactor complexes. , 2009, Thyroid : official journal of the American Thyroid Association.

[4]  A. Muñoz,et al.  Nuclear receptors: Genomic and non-genomic effects converge , 2009, Cell cycle.

[5]  N. Veldhoen,et al.  Roscovitine inhibits thyroid hormone‐induced tail regression of the frog tadpole and reveals a role for cyclin C/Cdk8 in the establishment of the metamorphic gene expression program , 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

[6]  M. Wade,et al.  Estrogenic exposure affects metamorphosis and alters sex ratios in the northern leopard frog (Rana pipiens): identifying critically vulnerable periods of development. , 2008, General and comparative endocrinology.

[7]  V. Trudeau,et al.  Hormone cross-regulation in the tadpole brain: developmental expression profiles and effect of T3 exposure on thyroid hormone- and estrogen-responsive genes in Rana pipiens. , 2007, General and comparative endocrinology.

[8]  Daniel Zalko,et al.  An in vivo multiwell-based fluorescent screen for monitoring vertebrate thyroid hormone disruption. , 2007, Environmental science & technology.

[9]  C. Helbing,et al.  Analysis of the Rana catesbeiana tadpole tail fin proteome and phosphoproteome during T3-induced apoptosis: identification of a novel type I keratin , 2007, BMC Developmental Biology.

[10]  P. Kosian,et al.  Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 2. Effects on the tail and hindlimb. , 2007, Aquatic toxicology.

[11]  C. Helbing,et al.  Genistein prevents thyroid hormone‐dependent tail regression of Rana catesbeiana tadpoles by targetting protein kinase C and thyroid hormone receptor α , 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

[12]  C. Helbing,et al.  Decreased cyclin-dependent kinase activity promotes thyroid hormone-dependent tail regression in Rana catesbeiana , 2007, Cell and Tissue Research.

[13]  D. Dix,et al.  Selection of Surrogate Animal Species for Comparative Toxicogenomics , 2006 .

[14]  William H. Benson,et al.  Genomic approaches for cross-species extrapolation in toxicology : proceedings from the Workshop on Emerging Molecular and Computational Approaches for Cross-Species Extrapolations, 18-22 July 2004, Portland, Oregon USA , 2006 .

[15]  M. Gunderson,et al.  The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development. , 2006, Aquatic toxicology.

[16]  C. Helbing,et al.  Evaluation of the effect of acetochlor on thyroid hormone receptor gene expression in the brain and behavior of Rana catesbeiana tadpoles. , 2006, Aquatic toxicology.

[17]  I. Lutz,et al.  Amphibians as model to study endocrine disrupters. , 2006, Journal of chromatography. A.

[18]  N. Veldhoen,et al.  Exposure to tetrabromobisphenol-A alters TH-associated gene expression and tadpole metamorphosis in the Pacific tree frog Pseudacris regilla. , 2006, Aquatic toxicology.

[19]  N. Veldhoen,et al.  Use of heterologous cDNA arrays and organ culture in the detection of thyroid hormone-dependent responses in a sentinel frog, Rana catesbeiana. , 2006, Comparative biochemistry and physiology. Part D, Genomics & proteomics.

[20]  A. Murk,et al.  T-screen to quantify functional potentiating, antagonistic and thyroid hormone-like activities of poly halogenated aromatic hydrocarbons (PHAHs). , 2006, Toxicology in vitro : an international journal published in association with BIBRA.

[21]  T. Yoshikawa,et al.  Di-(2-ethylhexyl) Phthalate Enhances Atopic Dermatitis-Like Skin Lesions in Mice , 2006, Environmental health perspectives.

[22]  R. Opitz,et al.  Evaluation of histological and molecular endpoints for enhanced detection of thyroid system disruption in Xenopus laevis tadpoles. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[23]  R. Opitz,et al.  Analysis of thyroid hormone receptor betaA mRNA expression in Xenopus laevis tadpoles as a means to detect agonism and antagonism of thyroid hormone action. , 2006, Toxicology and applied pharmacology.

[24]  P. Yen,et al.  Thyroid hormone action at the cellular, genomic and target gene levels , 2006, Molecular and Cellular Endocrinology.

[25]  P. Kosian,et al.  Evaluation of gene expression endpoints in the context of a Xenopus laevis metamorphosis-based bioassay to detect thyroid hormone disruptors. , 2006, Aquatic toxicology.

[26]  R. Waring,et al.  Endocrine disrupters: A human risk? , 2005, Molecular and Cellular Endocrinology.

[27]  Joseph E Tietge,et al.  Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[28]  Thomas Braunbeck,et al.  Description and initial evaluation of a Xenopus metamorphosis assay for detection of thyroid system‐disrupting activities of environmental compounds , 2005, Environmental toxicology and chemistry.

[29]  K. Parker,et al.  Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents*S , 2004, Molecular & Cellular Proteomics.

[30]  R. Zoeller,et al.  Timing of Thyroid Hormone Action in the Developing Brain: Clinical Observations and Experimental Findings , 2004, Journal of neuroendocrinology.

[31]  P. Foster,et al.  Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di (n-butyl) phthalate. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[32]  Christina M Howe,et al.  Toxicity of glyphosate‐based pesticides to four North American frog species , 2004, Environmental toxicology and chemistry.

[33]  J. Bassett,et al.  Mechanisms of thyroid hormone receptor-specific nuclear and extra nuclear actions , 2003, Molecular and Cellular Endocrinology.

[34]  Kate Werry,et al.  Expression profiles of novel thyroid hormone-responsive genes and proteins in the tail of Xenopus laevis tadpoles undergoing precocious metamorphosis. , 2003, Molecular endocrinology.

[35]  Kristina A Thayer,et al.  Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. , 2003, Environmental health perspectives.

[36]  L. Mayer,et al.  Exposure to 4-tert-octylphenol accelerates sexual differentiation and disrupts expression of steroidogenic factor 1 in developing bullfrogs. , 2003, Environmental health perspectives.

[37]  Kate Werry,et al.  Distinctive gene profiles occur at key points during natural metamorphosis in the Xenopus laevis tadpole tail , 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

[38]  Kate Werry,et al.  Exposure to the herbicide acetochlor alters thyroid hormone-dependent gene expression and metamorphosis in Xenopus Laevis. , 2002, Environmental health perspectives.

[39]  J. Tata Signalling through nuclear receptors , 2002, Nature Reviews Molecular Cell Biology.

[40]  T. Zoeller,et al.  Thyroid hormone, brain development, and the environment. , 2002, Environmental health perspectives.

[41]  P. Larsen,et al.  Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. , 2002, Endocrine reviews.

[42]  N. Veldhoen,et al.  Detection of environmental endocrine‐disruptor effects on gene expression in live Rana catesbeiana tadpoles using a tail fin biopsy technique , 2001, Environmental toxicology and chemistry.

[43]  C. Scott Findlay,et al.  Quantitative evidence for global amphibian population declines , 2000, Nature.

[44]  Yunbo Shi Amphibian Metamorphosis: From Morphology to Molecular Biology , 1999 .

[45]  R. Einspanier,et al.  Amphibians as a model to study endocrine disruptors: II. Estrogenic activity of environmental chemicals in vitro and in vivo. , 1999, The Science of the total environment.

[46]  J. McLachlan,et al.  A yeast estrogen screen for examining the relative exposure of cells to natural and xenoestrogens. , 1996, Environmental health perspectives.

[47]  Donald D. Brown,et al.  The analysis of complex developmental programmes: amphibian metamorphosis , 1996, Genes to cells : devoted to molecular & cellular mechanisms.

[48]  R. Evans,et al.  The RXR heterodimers and orphan receptors , 1995, Cell.

[49]  K. Umesono,et al.  The nuclear receptor superfamily: The second decade , 1995, Cell.

[50]  A. Wolffe,et al.  A role for nucleosome assembly in both silencing and activation of the Xenopus TR beta A gene by the thyroid hormone receptor. , 1995, Genes & development.

[51]  C. Helbing,et al.  3,5,3'-Triiodothyronine-induced carbamyl-phosphate synthetase gene expression is stabilized in the liver of Rana catesbeiana tadpoles during heat shock. , 1994, The Journal of biological chemistry.

[52]  J. Tata Early amphibian pattern formation Utrecht, 12–26 September 1993 , 1993, Mechanisms of Development.

[53]  M. Pfahl,et al.  Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors , 1992, Nature.

[54]  A. Ishizuya‐Oka,et al.  Induction of metamorphosis by thyroid hormone in anuran small intestine cultured organotypically in vitro , 1991, In Vitro Cellular & Developmental Biology - Animal.

[55]  J. Tata,et al.  Prolactin inhibits both thyroid hormone-induced morphogenesis and cell death in cultured amphibian larval tissues. , 1991, Developmental biology.

[56]  Y. Yaoita,et al.  Xenopus laevis alpha and beta thyroid hormone receptors. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[57]  D. Forrest,et al.  Contrasting developmental and tissue‐specific expression of alpha and beta thyroid hormone receptor genes. , 1990, The EMBO journal.

[58]  R. Evans,et al.  The c-erb-A gene encodes a thyroid hormone receptor , 1986, Nature.

[59]  H. Beug,et al.  The c-erb-A protein is a high-affinity receptor for thyroid hormone , 1986, Nature.

[60]  A. C. Taylor,et al.  Stages in the normal development of Rana pipiens larvae , 1946, The Anatomical record.

[61]  P. Kosian,et al.  Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 1. Effects on the brain. , 2007, Aquatic toxicology.

[62]  Yunbo Shi,et al.  Molecular and developmental analyses of thyroid hormone receptor function in Xenopus laevis, the African clawed frog. , 2006, General and comparative endocrinology.

[63]  W. Kloas Amphibians as a model for the study of endocrine disruptors. , 2002, International review of cytology.

[64]  L. Gilbert,et al.  Metamorphosis : postembryonic reprogramming of gene expression in amphibian and insect cells , 1996 .

[65]  C. Helbing,et al.  Sequential up-regulation of thyroid hormone beta receptor, ornithine transcarbamylase, and carbamyl phosphate synthetase mRNAs in the liver of Rana catesbeiana tadpoles during spontaneous and thyroid hormone-induced metamorphosis. , 1992, Developmental genetics.

[66]  B. White,et al.  Hormonal Control of Amphibian Metamorphosis , 1981 .

[67]  L. Gilbert,et al.  Metamorphosis : a problem in developmental biology , 1968 .