Audio frequency in vivo optical coherence elastography

We present a new approach to optical coherence elastography (OCE), which probes the local elastic properties of tissue by using optical coherence tomography to measure the effect of an applied stimulus in the audio frequency range. We describe the approach, based on analysis of the Bessel frequency spectrum of the interferometric signal detected from scatterers undergoing periodic motion in response to an applied stimulus. We present quantitative results of sub-micron excitation at 820 Hz in a layered phantom and the first such measurements in human skin in vivo.

[1]  William B. Spillman,et al.  Fiber optic sensors : an introduction for engineers and scientists , 2011 .

[2]  S. Boppart,et al.  Optical micro-scale mapping of dynamic biomechanical tissue properties. , 2008, Optics express.

[3]  Ruikang K. Wang,et al.  Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time , 2007 .

[4]  Riccardo Pratesi,et al.  Lasers and current optical techniques in biology , 2007 .

[5]  Ruikang K. Wang,et al.  Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue , 2006 .

[6]  S. Boppart,et al.  Optical coherence elastography of engineered and developing tissue. , 2006, Tissue engineering.

[7]  L. S. Taylor,et al.  A unified view of imaging the elastic properties of tissue. , 2005, The Journal of the Acoustical Society of America.

[8]  David D. Sampson,et al.  Optical coherence tomography , 2004 .

[9]  N Iftimia,et al.  OCT-based arterial elastography: robust estimation exploiting tissue biomechanics. , 2004, Optics express.

[10]  J. Fujimoto,et al.  Optical coherence tomographic elastography technique for measuring deformation and strain of atherosclerotic tissues , 2004, Heart.

[11]  J. Greenleaf,et al.  Selected methods for imaging elastic properties of biological tissues. , 2003, Annual review of biomedical engineering.

[12]  Armando Manduca,et al.  Imaging elastic properties of biological tissues by low-frequency harmonic vibration , 2003, Proc. IEEE.

[13]  David D Sampson,et al.  Delay and dispersion characteristics of a frequency-domain optical delay line for scanning interferometry. , 2003, Journal of the Optical Society of America. A, Optics, image science, and vision.

[14]  Zhongping Chen,et al.  Real-time phase-resolved functional optical coherence tomography by use of optical Hilbert transformation. , 2002, Optics Letters.

[15]  J. Walsh,et al.  Acoustic modulation and photon-phonon scattering in optical coherence tomography. , 2001, Applied optics.

[16]  S. Emelianov,et al.  Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics. , 1998, Ultrasound in medicine & biology.

[17]  J. Schmitt,et al.  OCT elastography: imaging microscopic deformation and strain of tissue. , 1998, Optics express.

[18]  J. Greenleaf,et al.  Ultrasound-stimulated vibro-acoustic spectrography. , 1998, Science.

[19]  Kevin J. Parker,et al.  Techniques for elastic imaging: a review , 1996 .

[20]  K J Parker,et al.  Imaging of the elastic properties of tissue--a review. , 1996, Ultrasound in medicine & biology.

[21]  K J Parker,et al.  Tissue response to mechanical vibrations for "sonoelasticity imaging". , 1990, Ultrasound in medicine & biology.

[22]  O. Sasaki,et al.  Sinusoidal phase modulating interferometry for surface profile measurement. , 1986, Applied optics.

[23]  J. Manschot,et al.  The mechanical properties of human skin in vivo , 1985 .

[24]  R O Potts,et al.  The dynamic mechanical properties of human skin in vivo. , 1983, Journal of biomechanics.