Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis.

[1]  D. Nathan,et al.  Insulin sensitivity during combined androgen blockade for prostate cancer. , 2006, The Journal of clinical endocrinology and metabolism.

[2]  Po Box,et al.  Excess risk of fatal coronary heart disease associated with diabetes in men and women:meta-analysis of 37 prospective cohort studies , 2006 .

[3]  N. Crepaz,et al.  Higher incidence of clear cell adenocarcinoma of the cervix and vagina among women born between 1947 and 1971 in the United States , 2011, Cancer Causes & Control.

[4]  Mark Woodward,et al.  Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies , 2005, BMJ : British Medical Journal.

[5]  H. Schulz,et al.  Role of Endocytosis in Cellular Uptake of Sex Steroids , 2005, Cell.

[6]  V. Mootha,et al.  Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. , 2005, Diabetes care.

[7]  E. Ford,et al.  Invited commentary: Acne in adolescence--protecting the heart but damaging the prostate later in life? , 2005, American journal of epidemiology.

[8]  D. Elahi,et al.  Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men. , 2005, The Journal of clinical endocrinology and metabolism.

[9]  I. Lambrinoudaki,et al.  Serum androgen levels and insulin resistance in postmenopausal women: association with hormone therapy, tibolone and raloxifene. , 2005, Maturitas.

[10]  J. Tuomilehto,et al.  Sex hormone-binding globulin and insulin-like growth factor-binding protein-1 as indicators of metabolic syndrome, cardiovascular risk, and mortality in elderly men. , 2005, The Journal of clinical endocrinology and metabolism.

[11]  V. Marks,et al.  Differences in pituitary and testicular function between diabetic patients on insulin and oral anti-diabetic agents , 1978, Diabetologia.

[12]  S. Yeh,et al.  Insulin and leptin resistance with hyperleptinemia in mice lacking androgen receptor. , 2005, Diabetes.

[13]  D. Grobbee,et al.  Endogenous sex hormones and metabolic syndrome in aging men. , 2005, The Journal of clinical endocrinology and metabolism.

[14]  B. Duncan,et al.  Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study. , 2004, American journal of epidemiology.

[15]  E. Tok,et al.  The androgenic profile of women with non-insulin-dependent diabetes mellitus. , 2004, The Journal of reproductive medicine.

[16]  U. Pagotto,et al.  Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors. , 2004, Diabetes.

[17]  R. Jones,et al.  Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life , 2004, Heart.

[18]  M. Heineman,et al.  Gender Difference in the Non‐Specific and Specific Immune Response in Humans , 2004, American journal of reproductive immunology.

[19]  K. Channer,et al.  The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. , 2004, The Journal of clinical endocrinology and metabolism.

[20]  J. Gónzalez-Buitrago,et al.  Partial androgen deficiency in aging type 2 diabetic men and its relationship to glycemic control. , 2004, Metabolism: clinical and experimental.

[21]  L. Niskanen,et al.  Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. , 2004, Diabetes care.

[22]  M. Supiano,et al.  Androgenicity and obesity are independently associated with insulin sensitivity in postmenopausal women. , 2004, Metabolism: clinical and experimental.

[23]  E. Boyko,et al.  Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. , 2004, Diabetes care.

[24]  Nader Rifai,et al.  Inflammatory markers and risk of developing type 2 diabetes in women. , 2004, Diabetes.

[25]  A. Matsumoto,et al.  Serum testosterone assays--accuracy matters. , 2004, The Journal of clinical endocrinology and metabolism.

[26]  J. Svartberg,et al.  The associations of endogenous testosterone and sex hormone-binding globulin with glycosylated hemoglobin levels, in community dwelling men. The Tromsø Study. , 2004, Diabetes & metabolism.

[27]  D. Schoenfeld,et al.  Measurement of free testosterone in normal women and women with androgen deficiency: comparison of methods. , 2004, The Journal of clinical endocrinology and metabolism.

[28]  Christina Wang,et al.  Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. , 2004, The Journal of clinical endocrinology and metabolism.

[29]  E. Barrett-Connor,et al.  Interrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study , 1992, Diabetologia.

[30]  E. Kilpatrick,et al.  The biological variation of sex hormone-binding globulin in type 2 diabetes: implications for sex hormone-binding globulin as a surrogate marker of insulin resistance. , 2004, Diabetes care.

[31]  C. Derby,et al.  Insulin resistance, hemostatic factors, and hormone interactions in pre- and perimenopausal women: SWAN. , 2003, The Journal of clinical endocrinology and metabolism.

[32]  P. Pietschmann,et al.  The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism , 2003, Experimental Gerontology.

[33]  P. Björntorp,et al.  A 5‐year follow‐up study of disease incidence in men with an abnormal hormone pattern , 2003, Journal of internal medicine.

[34]  M. Tschöp,et al.  Testosterone replacement therapy restores normal ghrelin in hypogonadal men. , 2003, The Journal of clinical endocrinology and metabolism.

[35]  David Handelsman,et al.  The short-term effects of high-dose testosterone on sleep, breathing, and function in older men. , 2003, The Journal of clinical endocrinology and metabolism.

[36]  T. Strandberg,et al.  Differing effects of oral and transdermal hormone replacement therapy on cardiovascular risk factors in healthy postmenopausal women. , 2003, The American journal of cardiology.

[37]  M. Tschöp,et al.  Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome , 2003, Journal of endocrinological investigation.

[38]  B. Gulanski,et al.  Association of endogenous sex hormones and insulin resistance among postmenopausal women: results from the Postmenopausal Estrogen/Progestin Intervention Trial. , 2003, The Journal of clinical endocrinology and metabolism.

[39]  Joachim Spranger,et al.  Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. , 2003, Diabetes.

[40]  M. Boyanov,et al.  Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency , 2003, The aging male : the official journal of the International Society for the Study of the Aging Male.

[41]  F. Berrino,et al.  Free estradiol and breast cancer risk in postmenopausal women: comparison of measured and calculated values. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[42]  S. Grundy,et al.  Sex steroid hormones, upper body obesity, and insulin resistance. , 2002, The Journal of clinical endocrinology and metabolism.

[43]  E. Riboli,et al.  Validity of free testosterone and free estradiol determinations in serum samples from postmenopausal women by theoretical calculations. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[44]  D. Dunger,et al.  Additive effects of insulin-sensitizing and anti-androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation. , 2002, The Journal of clinical endocrinology and metabolism.

[45]  Theo Stijnen,et al.  Advanced methods in meta‐analysis: multivariate approach and meta‐regression , 2002, Statistics in medicine.

[46]  E. Barrett-Connor,et al.  Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study. , 2002, Diabetes care.

[47]  B. Balkau,et al.  Androgen therapy improves insulin sensitivity and decreases leptin level in healthy adult men with low plasma total testosterone: a 3-month randomized placebo-controlled trial. , 2001, Diabetes care.

[48]  S. Weerakiet,et al.  Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in Asian women with polycystic ovary syndrome , 2001, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[49]  M. Ozata,et al.  The effects of metformin and diet on plasma testosterone and leptin levels in obese men. , 2001, Obesity research.

[50]  A. Bener,et al.  Association of acanthosis nigricans with risk of diabetes mellitus, and hormonal disturbances in arabian females: case-control study. , 2001, Maturitas.

[51]  C. Ahn,et al.  Polycystic ovarian syndrome (PCOS) and insulin resistance , 2001, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[52]  M. Parmar,et al.  The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer. , 2001, The Journal of clinical endocrinology and metabolism.

[53]  N. Skakkebaek,et al.  Cardiovascular risk factors in men: The role of gonadal steroids and sex hormone-binding globulin. , 2001, Metabolism: clinical and experimental.

[54]  B. Çakır,et al.  Insulin Resistance in Nonobese Patients with Polycystic Ovary Syndrome , 2001, Hormone Research in Paediatrics.

[55]  M. V. D. Merwe,et al.  Lactate and glycerol release from adipose tissue in lean, obese, and diabetic women from South Africa. , 2001, The Journal of clinical endocrinology and metabolism.

[56]  W. Rosner,et al.  An extraordinarily inaccurate assay for free testosterone is still with us. , 2001, The Journal of clinical endocrinology and metabolism.

[57]  M. Taskinen,et al.  Effects of Oral and Transdermal Estrogen Replacement Therapy on Markers of Coagulation, Fibrinolysis, Inflammation and Serum Lipids and Lipoproteins in Postmenopausal Women , 2001, Thrombosis and Haemostasis.

[58]  L. Niskanen,et al.  Relationship of the metabolic syndrome and obesity to polycystic ovary syndrome: a controlled, population-based study. , 2001, American journal of obstetrics and gynecology.

[59]  E. Cho,et al.  Differences in body fat distribution and antioxidant status in Korean men with cardiovascular disease with or without diabetes. , 2001, The American journal of clinical nutrition.

[60]  Straub,et al.  Association of increased C-peptide serum levels and testosterone in type 2 diabetes. , 2000, European journal of internal medicine.

[61]  J. Berlin,et al.  Effects of testosterone replacement in hypogonadal men. , 2000, The Journal of clinical endocrinology and metabolism.

[62]  A. Iranmanesh,et al.  Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. , 2000, The Journal of clinical endocrinology and metabolism.

[63]  E. Barrett-Connor,et al.  Sex differences in the association of endogenous sex hormone levels and glucose tolerance status in older men and women. , 2000, Diabetes care.

[64]  J. Mckinlay,et al.  Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. , 2000, Diabetes care.

[65]  EC Tsai,et al.  Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men , 2000, International Journal of Obesity.

[66]  S. Chearskul,et al.  Study of plasma hormones and lipids in healthy elderly Thais compared to patients with chronic diseases: diabetes mellitus, essential hypertension and coronary heart disease. , 2000, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[67]  G. Beall,et al.  Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. , 2000, JAMA.

[68]  M. Yamakido,et al.  Association of sex hormone-binding globulin and insulin resistance among Japanese-American subjects. , 2000, Diabetes research and clinical practice.

[69]  R. Sacco,et al.  Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in Hispanic postmenopausal women. , 2000, Diabetes care.

[70]  A. Vermeulen,et al.  A critical evaluation of simple methods for the estimation of free testosterone in serum. , 1999, The Journal of clinical endocrinology and metabolism.

[71]  G A Colditz,et al.  Guidelines for healthy weight. , 1999, The New England journal of medicine.

[72]  J. Berlin,et al.  Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. , 1999, The Journal of clinical endocrinology and metabolism.

[73]  M. S. Khan,et al.  Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane , 1999, The Journal of Steroid Biochemistry and Molecular Biology.

[74]  K. Walker,et al.  Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type 2 diabetes. , 1999, Diabetes care.

[75]  A. Lanzone,et al.  Impact of insulin and body mass index on metabolic and endocrine variables in polycystic ovary syndrome. , 1999, Metabolism: clinical and experimental.

[76]  M. Cavaghan,et al.  Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. , 1999, Diabetes care.

[77]  D. Simon,et al.  Hormonal status and NIDDM in the European and Melanesian populations of New Caledonia: a case-control study , 1998, International Journal of Obesity.

[78]  A. O’Sullivan,et al.  The route of estrogen replacement therapy confers divergent effects on substrate oxidation and body composition in postmenopausal women. , 1998, The Journal of clinical investigation.

[79]  J. Bland,et al.  Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women , 1998, Clinical endocrinology.

[80]  G. Giles,et al.  Do Postmenopausal Women With NIDDM Have a Reduced Capacity to Deposit and Conserve Lower-Body Fat? , 1998, Diabetes Care.

[81]  M. Benito,et al.  Tumor Necrosis Factor-α Causes Insulin Receptor Substrate-2-Mediated Insulin Resistance and Inhibits Insulin-Induced Adipogenesis in Fetal Brown Adipocytes. , 1998, Endocrinology.

[82]  E. Szeszycki.  Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. , 1997, JPEN. Journal of parenteral and enteral nutrition.

[83]  W. Rosner.  Errors in the measurement of plasma free testosterone. , 1997, The Journal of clinical endocrinology and metabolism.

[84]  R. Vettor,et al.  Effects of acute hyperinsulinemia on testosterone serum concentrations in adult obese and normal-weight men. , 1997, Metabolism: clinical and experimental.

[85]  E. Barrett-Connor,et al.  Sex Hormone-Binding Globulin and Glucose Tolerance in Postmenopausal Women: The Rancho Bernardo Study , 1997, Diabetes Care.

[86]  D. Schoenfeld,et al.  Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. , 1996, The Journal of clinical endocrinology and metabolism.

[87]  P. Björntorp,et al.  The Pituitary-Gonadal Axis and Health in Elderly Men: A Study of Men Born in 1913 , 1996, Diabetes.

[88]  C. Chlouverakis,et al.  Ovarian function in women with non‐insulin dependent diabetes mellitus , 1996, Clinical endocrinology.

[89]  I. Mattiasson,et al.  Low testosterone and insulin resistance in hypertension-prone men. , 1996, Journal of human hypertension.

[90]  N. Ancy,et al.  The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. , 1996 .

[91]  J. Rood,et al.  Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women--a clinical research center study. , 1996, The Journal of clinical endocrinology and metabolism.

[92]  P. Björntorp,et al.  Mechanisms Behind Insulin Resistance in Rat Skeletal Muscle After Oophorectomy and Additional Testosterone Treatment , 1996, Diabetes.

[93]  L. Kuller,et al.  Low levels of sex hormone-binding globulin and testosterone predict the development of non-insulin-dependent diabetes mellitus in men. MRFIT Research Group. Multiple Risk Factor Intervention Trial. , 1996, American journal of epidemiology.

[94]  P. Björntorp.  The regulation of adipose tissue distribution in humans. , 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[95]  R. Henry,et al.  The expression of TNF alpha by human muscle. Relationship to insulin resistance. , 1996, The Journal of clinical investigation.

[96]  J. Kaufman,et al.  INFLUENCE OF SOME SEX HORMONE-BINDING GLOBULIN AND ANDROGEN LEVELS IN AGING OR OBESE MALES , 1996 .

[97]  S. Haffner.  Sex hormone-binding protein, hyperinsulinemia, insulin resistance and noninsulin-dependent diabetes. , 1996, Hormone research.

[98]  R. Casaburi,et al.  The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. , 1996, The New England journal of medicine.

[99]  P. Mårin,et al.  Testosterone and regional fat distribution. , 1995, Obesity research.

[100]  B. Spiegelman,et al.  Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. , 1995, The Journal of clinical investigation.

[101]  P. Björntorp,et al.  Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. , 1995, The Journal of clinical endocrinology and metabolism.

[102]  J. Kaufman,et al.  Pathogenesis of the decreased androgen levels in obese men. , 1994, The Journal of clinical endocrinology and metabolism.

[103]  S. Haffner,et al.  Decreased testosterone and dehydroepiandrosterone sulfate concentrations are associated with increased insulin and glucose concentrations in nondiabetic men. , 1994, Metabolism: clinical and experimental.

[104]  P. Björntorp,et al.  Testosterone Concentrations in Women and Men With NIDDM , 1994, Diabetes Care.

[105]  M. Laakso,et al.  Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men , 1994, Diabetes.

[106]  Y. Hsiao,et al.  Hormonal changes in elderly men with non-insulin-dependent diabetes mellitus and the hormonal relationships to abdominal adiposity. , 1994, Gerontology.

[107]  S. Haffner,et al.  Decreased sex hormone-binding globulin predicts noninsulin-dependent diabetes mellitus in women but not in men. , 1993, The Journal of clinical endocrinology and metabolism.

[108]  K. Birkeland,et al.  Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes. , 1993, The Journal of clinical endocrinology and metabolism.

[109]  G. B. Phillips.  Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity. , 1993, Metabolism: clinical and experimental.

[110]  L. Sjöström,et al.  The effects of testosterone treatment on body composition and metabolism in middle-aged obese men. , 1992, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

[111]  J. S. Tenover,et al.  Effects of testosterone supplementation in the aging male. , 1992, The Journal of clinical endocrinology and metabolism.

[112]  E. Barrett-Connor,et al.  Lower endogenous androgens predict central adiposity in men. , 1992, Annals of epidemiology.

[113]  S. Haffner,et al.  Relationship of sex hormone-binding globulin to lipid, lipoprotein, glucose, and insulin concentrations in postmenopausal women. , 1992, Metabolism: clinical and experimental.

[114]  P. Björntorp,et al.  Effect of testosterone on abdominal adipose tissue in men. , 1991, International journal of obesity.

[115]  E. Barrett-Connor,et al.  Fasting plasma glucose levels and endogenous androgens in non-diabetic postmenopausal women. , 1991, Clinical science.

[116]  G Lindstedt,et al.  Low Sex-Hormone-Binding Globulin Concentration as Independent Risk Factor for Development of NIDDM: 12-Yr Follow-Up of Population Study of Women in Gothenburg, Sweden , 1991, Diabetes.

[117]  R. Pasquali,et al.  Effect of obesity and body fat distribution on sex hormones and insulin in men. , 1991, Metabolism: clinical and experimental.

[118]  L. Sjöström,et al.  Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. , 1990, Metabolism: clinical and experimental.

[119]  E. Barrett-Connor,et al.  Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. , 1988, Circulation.

[120]  G. Beastall,et al.  Androgen Levels in Men with Diabetes Mellitus , 1988, Diabetic medicine : a journal of the British Diabetic Association.

[121]  T. Wilke,et al.  Total testosterone, free-androgen index, calculated free testosterone, and free testosterone by analog RIA compared in hirsute women and in otherwise-normal women with altered binding of sex-hormone-binding globulin. , 1987, Clinical chemistry.

[122]  A. Maccuish,et al.  Oestradiol levels in diabetic men with and without a previous myocardial infarction. , 1987, The Quarterly journal of medicine.

[123]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[124]  G. B. Phillips.  Evidence for hyperestrogenemia as the link between diabetes mellitus and myocardial infarction. , 1984, The American journal of medicine.

[125]  S. Andò,et al.  Androgen plasma levels in male diabetics , 1984, Journal of endocrinological investigation.

[126]  T. Bäckström,et al.  Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. , 1982, Journal of steroid biochemistry.

[127]  J. Dunn,et al.  Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. , 1981, The Journal of clinical endocrinology and metabolism.

[128]  J. Meunier,et al.  Pituitary-testicular axis in diabetic men with and without sexual impotence. , 1978, Diabete & metabolisme.

[129]  G B Phillips,et al.  Relationship between serum sex hormones and glucose, insulin and lipid abnormalities in men with myocardial infarction. , 1977, Proceedings of the National Academy of Sciences of the United States of America.