Imaging the cavernous nerves in the rat prostate using optical coherence tomography

Improvements in identification, imaging, and visualization of the cavernous nerves (CNs) during radical prostatectomy, which are responsible for erectile function, may improve nerve preservation and post‐operative potency. Optical coherence tomography (OCT) is capable of real‐time, high‐resolution, cross‐sectional, in vivo tissue imaging. The rat prostate serves as an excellent model for studying the use of OCT for imaging the CNs, as the rat CN is a large, visible, and distinct bundle allowing for easy identification with OCT in addition to histologic confirmation.

[1]  Jin U. Kang,et al.  All-fiber common-path optical coherence tomography: sensitivity optimization and system analysis , 2005, IEEE Journal of Selected Topics in Quantum Electronics.

[2]  Yingtian Pan,et al.  Fluorescence guided optical coherence tomography for the diagnosis of early bladder cancer in a rat model. , 2005, The Journal of urology.

[3]  Y T Pan,et al.  High-resolution imaging characterization of bladder dynamic morphophysiology by time-lapse optical coherence tomography. , 2005, Optics letters.

[4]  Elena V Zagaynova,et al.  Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography. , 2005, Journal of endourology.

[5]  Grigory V. Gelikonov,et al.  Cost-effective all-fiber autocorrelator-based 1300-nm OCT system , 2005, SPIE BiOS.

[6]  A. Costello,et al.  Anatomical studies of the neurovascular bundle and cavernosal nerves , 2004, BJU international.

[7]  S. Bastacky,et al.  Enhancing early bladder cancer detection with fluorescence-guided endoscopic optical coherence tomography. , 2003, Optics letters.

[8]  Huikai Xie,et al.  Endoscopic optical coherence tomography with a modified microelectromechanical systems mirror for detection of bladder cancers. , 2003, Applied optics.

[9]  C. Kendall,et al.  Optical diagnostics in urology: current applications and future prospects , 2003, BJU international.

[10]  Elena V Zagaynova,et al.  In vivo optical coherence tomography feasibility for bladder disease. , 2002, The Journal of urology.

[11]  D L Farkas,et al.  Detection of tumorigenesis in rat bladders with optical coherence tomography. , 2001, Medical physics.

[12]  F. Koenig.  Optical Coherence Tomography in Urology , 2001 .

[13]  Michael A. Marcus,et al.  All-fiber optic coherence domain interferometric techniques , 2001, SPIE Optics East.

[14]  S A Boppart,et al.  Real-time optical coherence tomography for minimally invasive imaging of prostate ablation. , 2001, Computer aided surgery : official journal of the International Society for Computer Aided Surgery.

[15]  J. Fujimoto,et al.  Imaging needle for optical coherence tomography. , 2000, Optics letters.

[16]  J. Fujimoto,et al.  Optical coherence tomography as a method for identifying benign and malignant microscopic structures in the prostate gland. , 2000, Urology.

[17]  P. Walsh,et al.  Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. , 2000, Urology.

[18]  S A Boppart,et al.  High resolution imaging of transitional cell carcinoma with optical coherence tomography: feasibility for the evaluation of bladder pathology. , 1999, The British journal of radiology.

[19]  W. Catalona,et al.  Potency, continence and complication rates in 1,870 consecutive radical retropubic prostatectomies. , 1999, The Journal of urology.

[20]  B E Bouma,et al.  Forward-imaging instruments for optical coherence tomography. , 1997, Optics letters.

[21]  V E Weldon,et al.  Continence, potency and morbidity after radical perineal prostatectomy. , 1997, The Journal of urology.

[22]  J. Richie,et al.  Patient-reported impotence and incontinence after nerve-sparing radical prostatectomy. , 1997, Journal of the National Cancer Institute.

[23]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[24]  J. Fujimoto,et al.  Optical biopsy in human urologic tissue using optical coherence tomography. , 1997, The Journal of urology.

[25]  B. Golubovic,et al.  Single mode fiber-optic catheter/endoscope for optical coherence tomography , 1996, Summaries of papers presented at the Conference on Lasers and Electro-Optics.

[26]  G. Murphy,et al.  National patterns of prostate cancer treatment by radical prostatectomy: results of a survey by the American College of Surgeons Commission on Cancer. , 1994, The Journal of urology.

[27]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991, LEOS '92 Conference Proceedings.