Astrocyte as a Detector of Synchronous Events of a Neural Network

The principles and mechanisms of information processing in the brain are among key fundamental problems of modern science. Neurons being the main signal cells of the brain provide the transmission and transformation of sequences of electrical pulses in a neural network. Signal networks include not only neurons but also glial cells called astrocytes executing regulatory functions, as is accepted in neurobiology. In this work, a morphofunctional (compartment) model of an astrocyte has been proposed. It has been shown that the astrocyte can serve as a detector of synchronous events of different points of the neural network, generating a calcium response signal. In turn, this signal induces the synchronous ejection of neuroactive substances to the corresponding points of the network, which can enhance the spatial synchronization of neurons or the synchronous modulation of different neural paths.

[1]  H. Othmer,et al.  Spatiotemporal characteristics of calcium dynamics in astrocytes. , 2009, Chaos.

[2]  Victor Kazantsev,et al.  Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity. , 2014, Cell calcium.

[3]  Victor B. Kazantsev,et al.  Bi-directional astrocytic regulation of neuronal activity within a network , 2012, Front. Comput. Neurosci..

[4]  J. Rinzel,et al.  Equations for InsP3 receptor-mediated [Ca2+]i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism. , 1994, Journal of theoretical biology.

[5]  Eshel Ben-Jacob,et al.  The Astrocyte as a Gatekeeper of Synaptic Information Transfer , 2006, Neural Computation.

[6]  Nicolas Liaudet,et al.  Astrocyte Ca2+ signalling: an unexpected complexity , 2014, Nature Reviews Neuroscience.

[7]  S. Morfu,et al.  Propagation failure in discrete bistable reaction-diffusion systems: theory and experiments. , 2001, Physical review. E, Statistical, nonlinear, and soft matter physics.

[8]  E. Ben-Jacob,et al.  Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes , 2009, Journal of biological physics.

[9]  Ghanim Ullah,et al.  Anti-phase calcium oscillations in astrocytes via inositol (1, 4, 5)-trisphosphate regeneration. , 2006, Cell calcium.

[10]  Eshel Ben-Jacob,et al.  A Tale of Two Stories: Astrocyte Regulation of Synaptic Depression and Facilitation , 2011, PLoS Comput. Biol..

[11]  Vadim Turlapov,et al.  Subcellular location of astrocytic calcium stores favors extrasynaptic neuron-astrocyte communication. , 2013, Cell calcium.

[12]  V B Kazantsev,et al.  Spontaneous calcium signals induced by gap junctions in a network model of astrocytes. , 2009, Physical review. E, Statistical, nonlinear, and soft matter physics.

[13]  Klaus Obermayer,et al.  Spatial separation of two different pathways accounting for the generation of calcium signals in astrocytes , 2017, PLoS Comput. Biol..

[14]  V B Kazantsev,et al.  Bifurcation mechanisms of regular and chaotic network signaling in brain astrocytes. , 2011, Chaos.

[15]  D E Postnov,et al.  Dynamical patterns of calcium signaling in a functional model of neuron–astrocyte networks , 2009, Journal of biological physics.

[16]  S. V. Stasenko,et al.  Synaptic multistability and network synchronization induced by the neuron–glial interaction in the brain , 2017 .

[17]  S. Oloff,et al.  Hippocampal astrocytes in situ exhibit calcium oscillations that occur independent of neuronal activity. , 2002, Journal of neurophysiology.