A Comparison of Albumin and Saline for Fluid Resuscitation in the Intensive Care Unit

The Saline versus Albumin Fluid Evaluation (SAFE) Study is a collaboration of the Australian and New Zealand Intensive Care Society Clinical Trials Group, the Australian Red Cross Blood Service, and the George Institute for International Health. The writing committee (Simon Finfer, M.B., B.S., Rinaldo Bellomo, M.B., B.S., M.D., Neil Boyce, M.B., B.S., Ph.D., Julie French, R.N., John Myburgh, M.B., B.Ch., Ph.D., and Robyn Norton, Ph.D., M.P.H.) takes responsibility for the content of this article. Address reprint requests to Dr. Finfer at ANZICS CTG, Level 3, 10 Ievers St., Carlton, VIC 3053, Australia, or at ctg@anzics.com.au.

[1]  J. Boldt New Light on Intravascular Volume Replacement Regimens: What Did We Learn from the Past Three Years? , 2003, Anesthesia and analgesia.

[2]  G. Guyatt,et al.  Colloid Use for Fluid Resuscitation: Evidence and Spin , 2001, Annals of Internal Medicine.

[3]  R. Collins,et al.  Reliable assessment of the effects of treatment on mortality and major morbidity, I: clinical trials , 2001, The Lancet.

[4]  S. Kleinman,et al.  A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care , 1999 .

[5]  C. Sprung,et al.  Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. , 1998, Critical care medicine.

[6]  Cochrane Injuries,et al.  Human albumin administration in critically ill patients: systematic review of randomised controlled trials. , 1998, BMJ.

[7]  M. Lamy,et al.  The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. , 1994, American journal of respiratory and critical care medicine.

[8]  I. L. Cohen Guidelines for the use of innovative therapies in sepsis. , 1993, Critical care medicine.

[9]  E. Draper,et al.  APACHE II: A severity of disease classification system , 1985, Critical care medicine.

[10]  B. Jennett,et al.  Assessment of coma and impaired consciousness. A practical scale. , 1974, Lancet.

[11]  M. Wilkes,et al.  Patient survival after human albumin administration. A meta-analysis of randomized, controlled trials. , 2001, Annals of internal medicine.

[12]  Whether Albumin Therapy Improves or Worsens Survival of Critically Ill Patients Is Not Known , 2001, Annals of Internal Medicine.

[13]  D. Cook,et al.  Crystalloids vs. colloids in fluid resuscitation: a systematic review. , 1999, Critical care medicine.