Tanshinone II-A attenuates and stabilizes atherosclerotic plaques in apolipoprotein-E knockout mice fed a high cholesterol diet.

[1]  Peiqing Liu,et al.  Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression. , 2011, European journal of pharmacology.

[2]  Y. Huang,et al.  Evaluation of foam cell formation in cultured macrophages: an improved method with Oil Red O staining and DiI-oxLDL uptake , 2010, Cytotechnology.

[3]  Jun-Rong Du,et al.  Tanshinone IIA inhibits smooth muscle proliferation and intimal hyperplasia in the rat carotid balloon-injured model through inhibition of MAPK signaling pathway. , 2010, Journal of ethnopharmacology.

[4]  R. Virmani,et al.  Correlation between carotid intimal/medial thickness and atherosclerosis: a point of view from pathology. , 2010, Arteriosclerosis, thrombosis, and vascular biology.

[5]  Suowen Xu,et al.  Development of an optimized protocol for primary culture of smooth muscle cells from rat thoracic aortas , 2009, Cytotechnology.

[6]  E. Zhou,et al.  Tanshinone II(A) elicited vasodilation in rat coronary arteriole: roles of nitric oxide and potassium channels. , 2009, European journal of pharmacology.

[7]  F. Howe,et al.  Rosiglitazone Reduces the Development and Rupture of Experimental Aortic Aneurysms , 2009, Circulation.

[8]  De-Pei Liu,et al.  Human Paraoxonase Gene Cluster Transgenic Overexpression Represses Atherogenesis and Promotes Atherosclerotic Plaque Stability in ApoE-Null Mice , 2009, Circulation research.

[9]  Yan Zhu,et al.  The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS , 2009, The Journal of Steroid Biochemistry and Molecular Biology.

[10]  Soo-Ho Choi,et al.  Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein: Toll-Like Receptor 4– and Spleen Tyrosine Kinase–Dependent Activation of NADPH Oxidase 2 , 2009, Circulation research.

[11]  N. Webb Getting to the core of atherosclerosis , 2008, Nature Medicine.

[12]  Young-Chae Chang,et al.  Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP‐9 activity through AKT signaling pathway , 2008, Journal of cellular biochemistry.

[13]  T. Hibi,et al.  Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. , 2008, Pharmacology & therapeutics.

[14]  Hui Zhang,et al.  Tanshinone IIA downregulates the CD40 expression and decreases MMP-2 activity on atherosclerosis induced by high fatty diet in rabbit. , 2008, Journal of ethnopharmacology.

[15]  P. Komesaroff,et al.  A Preparation of Herbal Medicine Salvia miltiorrhiza Reduces Expression of Intercellular Adhesion Molecule-1 and Development of Atherosclerosis in Apolipoprotein E-Deficient Mice , 2008, Journal of cardiovascular pharmacology.

[16]  Hui Zhang,et al.  Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet. , 2007, Life sciences.

[17]  R. Parker,et al.  Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 , 2007, Nature.

[18]  Ping Wang,et al.  Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress. , 2007, Vascular pharmacology.

[19]  Hong-Sheng Zhang,et al.  Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells. , 2007, Biochemical pharmacology.

[20]  Horng-mo Lee,et al.  Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells. , 2007, Mitochondrion.

[21]  Weirong Wang,et al.  Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism. , 2006, Journal of ethnopharmacology.

[22]  S. Jang,et al.  Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways. , 2006, European journal of pharmacology.

[23]  T. Cheng Danshen: a popular chinese cardiac herbal drug. , 2006, Journal of the American College of Cardiology.

[24]  Hong Wang,et al.  Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells. , 2005, Journal of ethnopharmacology.

[25]  Z. Qian,et al.  Tanshinone inhibits intimal hyperplasia in the ligated carotid artery in mice. , 2005, Journal of ethnopharmacology.

[26]  G. Angelini,et al.  Plaque Rupture After Short Periods of Fat Feeding in the Apolipoprotein E–Knockout Mouse: Model Characterization and Effects of Pravastatin Treatment , 2005, Circulation.

[27]  J. Keaney,et al.  Role of oxidative modifications in atherosclerosis. , 2004, Physiological reviews.

[28]  R. Park,et al.  Tanshinone IIA from Salvia miltiorrhiza Inhibits Inducible Nitric Oxide Synthase Expression and Production of TNF-α, IL-1β and IL-6 in Activated RAW 264.7 Cells , 2003 .

[29]  P. Libby Inflammation in atherosclerosis , 2002, Nature.

[30]  C. Kataoka,et al.  New Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E-Knockout Mice , 2001, Circulation.

[31]  X. Niu,et al.  Tanshinone II-A inhibits low density lipoprotein oxidation in vitro , 2000, Free radical research.

[32]  R. Ross,et al.  Atherosclerosis is an Inflammatory Disease , 1998 .

[33]  Daniel Steinberg,et al.  Low Density Lipoprotein Oxidation and Its Pathobiological Significance* , 1997, The Journal of Biological Chemistry.

[34]  N. Maeda,et al.  Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. , 1992, Science.

[35]  E. Rubin,et al.  Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells , 1992, Cell.

[36]  R. Williams,et al.  Quantitative assessment of atherosclerotic lesions in mice. , 1987, Atherosclerosis.

[37]  Ming-Wei Wang,et al.  The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism. , 2009, Endocrinology.

[38]  R. Ross,et al.  ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.