Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN

[1]  M. Ghosh,et al.  The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation* , 2012, The Journal of Biological Chemistry.

[2]  N. Lin,et al.  HSP90 as a platform for the assembly of more effective cancer chemotherapy. , 2012, Biochimica et biophysica acta.

[3]  S. Simon,et al.  Knock Down of Heat Shock Protein 27 (HspB1) Induces Degradation of Several Putative Client Proteins , 2012, PloS one.

[4]  A. Mauk,et al.  Roles of the N‐ and C‐terminal sequences in Hsp27 self‐association and chaperone activity , 2012, Protein science : a publication of the Protein Society.

[5]  D. Spandidos,et al.  Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review). , 2011, International journal of oncology.

[6]  M. Gleave,et al.  Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch , 2011, Cell Death and Differentiation.

[7]  Stephen L. Brown,et al.  Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival , 2012, Molecular Cancer.

[8]  G. M. Nagaraja,et al.  Silencing hsp25/hsp27 Gene Expression Augments Proteasome Activity and Increases CD8+ T-Cell–Mediated Tumor Killing and Memory Responses , 2011, Cancer Prevention Research.

[9]  Yu-jing Fan,et al.  [Wnt/b-catenin signaling pathway affects the protein expressions of caspase-3, XIAP and Grp-78 in hepatocellular carcinoma]. , 2011, Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.

[10]  M. Radrizzani,et al.  Different Conformations of Phosphatase and Tensin Homolog, Deleted on Chromosome 10 (PTEN) Protein within the Nucleus and Cytoplasm of Neurons , 2011, PloS one.

[11]  Jong-Suk Kim,et al.  Estrogen receptor α induces down-regulation of PTEN through PI3-kinase activation in breast cancer cells. , 2011, Molecular medicine reports.

[12]  R. Luben,et al.  Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors , 2011, BMC Cancer.

[13]  Xuejun Jiang,et al.  Regulation of PTEN Stability and Activity by Plk3* , 2010, The Journal of Biological Chemistry.

[14]  S. Simon,et al.  Dynamic processes that reflect anti-apoptotic strategies set up by HspB1 (Hsp27). , 2010, Experimental cell research.

[15]  F. Gago,et al.  P-Cadherin and β-catenin are useful prognostic markers in breast cancer patients; β-catenin interacts with heat shock protein Hsp27 , 2008, Cell Stress and Chaperones.

[16]  M. Sherman,et al.  Hsp27 modulates p53 signaling and suppresses cellular senescence. , 2007, Cancer research.

[17]  M. Sherman,et al.  Heat Shock Proteins in Cancer , 2007, Annals of the New York Academy of Sciences.

[18]  G. Kroemer,et al.  Heat Shock Proteins 27 and 70: Anti-Apoptotic Proteins with Tumorigenic Properties , 2006, Cell cycle.

[19]  C. Jomary,et al.  Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. , 2006, Investigative ophthalmology & visual science.

[20]  C. Jantschitsch,et al.  Silencing the hsp25 Gene Eliminates Migration Capability of the Highly Metastatic Murine 4T1 Breast Adenocarcinoma Cell , 2005, Tumor Biology.

[21]  Stuart K. Calderwood,et al.  Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications , 2005, Cell stress & chaperones.

[22]  M. Radrizzani,et al.  Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development. , 2004, Brain research. Molecular brain research.

[23]  A. Kenworthy,et al.  Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy. , 2001, Methods.

[24]  L. Cantley,et al.  New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[25]  F. Gago,et al.  Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy , 1998, International journal of cancer.