A mitomycin C-resistant Jensen rat sarcoma: isolation and transplantation studies.

A transplantable rat tumor, the Jensen sarcoma, has been selected for resistance to the action of mitomycin C. Initial treatment consisted of 0.15 mg/kg. After seven passages through rats, the treatment dose was raised to 0.5 mg/kg. Under normal circumstances, this dose of antibiotic completely inhibits tumor growth. The stability of this resistance was proved by passage of the tumor through more than twenty generations in untreated rats. The antibiotic-resistant tumor was also found to have the following characteristics: ( a ) growth as a firm mass with less necrosis and central liquefaction than is ordinarily observed in the sensitive sarcoma; ( b ) a greater tendency to persist for longer periods of time in the rat host before showing drastic signs of regression; ( c ) a slow growth rate in cortisone-treated Swiss mice; ( d ) poor transplantability to neonatal mice; and ( e ) cross-resistance to nitrogen mustard in tests with the cortisone-treated Swiss mouse.

[1]  Biological Activities of Steroids in Relation to Cancer , 1961, Pediatrics.

[2]  I. Hirono.  Comparative studies on histological features of the original strain and resistant subline to nitrogen mustard N-oxide in the ascites hepatoma. , 1960, Gan.

[3]  S. C. Lyster,et al.  Steroids and Experimental Mammary Cancer , 1960 .

[4]  P. C. Merker,et al.  A study of human epidermoid carcinoma (H.Ep.#3) growing in conditioned Swiss mice. I. Applicability to chemotherapy studies. , 1959, Cancer research.

[5]  M. Schlesinger,et al.  The transplantability of strain-specific and nonspecific mouse tumors to pretreated rats. , 1959, Cancer research.

[6]  S. Oboshi.  CROSS-RESISTANCE BETWEEN MITOMYCIN C AND ALKYLATING AGENTS IN EXPERIMENTAL CANCER CHEMOTHERAPY , 1959 .

[7]  K. Sugiura.  Studies in a tumor spectrum. VIII. The effect of mitomycin C on the growth of a variety of mouse, rat, and hamster tumors. , 1959, Cancer research.

[8]  A. Sartorelli,et al.  The development and biochemical characterization of resistance to azaserine in a TA 3 ascites carcinoma. , 1958, Cancer research.

[9]  Tomizo Yoshida.  CONTRIBUTIONS OF THE ASCITES HEPATOMA TO THE CONCEPT OF MALIGNANCY OF CANCER , 1955, Annals of the New York Academy of Sciences.

[10]  S. Hibino.  Chemotherapy of leukemia. , 1956, Gan.

[11]  I. Hirono.  Some Properties of Yoshida Sarcoma Cells Resistant to Methyl-bis-(β-chlorethyl)-amine N-oxide.∗ , 1955 .

[12]  H. Jackson.  The Development of Resistance in the Walker Carcinosarcoma to the Action of Triethylene Melamine , 1954, British Journal of Cancer.

[13]  S. Sternberg,et al.  6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals. , 1953, Cancer research.

[14]  J. Burchenal,et al.  The induction of resistance to 4-amino-N10-methylpteroylglutamic acid in a strain of transmitted mouse leukemia. , 1950, Science.