The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits.

The nutritional jujube ( Ziziphus jujube Mill.) fruit belonging to the Rhamnaceous family grows mostly in Europe, southern and eastern Asia, and Australia, especially the inland region of northern China. Jujube has a long history of usage as a fruit and remedy. The main biologically active components are vitamin C, phenolics, flavonoids, triterpenic acids, and polysaccharides. Recent phytochemical studies of jujube fruits have shed some light on their biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, and gastrointestinal protective activities and inhibition of foam cell formation in macrophages. A stronger focus on clinical studies and phytochemical definition of jujube fruits will be essential for future research efforts. This review may be useful for predicting other medicinal uses and potential drug or food interactions and may be beneficial for people living where the jujube fruits are prevalent and health care resources are scarce.

[1]  A. Bader,et al.  Flavonoids of Zizyphus jujuba L. and Zizyphus spina-christi (L.) Willd (Rhamnaceae) fruits , 2009 .

[2]  J. Duan,et al.  Bioactive components in the fruits of Ziziphus jujuba Mill. against the inflammatory irritant action of Euphorbia plants. , 2012, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[3]  M. Friedman,et al.  Changes in free amino acid, protein, and flavonoid content in jujube (Ziziphus jujube) fruit during eight stages of growth and antioxidative and cancer cell inhibitory effects by extracts. , 2012, Journal of agricultural and food chemistry.

[4]  Qing-Han Gao,et al.  Textural characteristic, antioxidant activity, sugar, organic acid, and phenolic profiles of 10 promising jujube (Ziziphus jujuba Mill.) selections. , 2012, Journal of food science.

[5]  L. C. Anderson,et al.  The jujube (Ziziphus jujuba Mill.), a multipurpose plant , 2002 .

[6]  S. Su,et al.  Characterization of triterpenic acids in fruits of ziziphus species by HPLC-ELSD-MS. , 2010, Journal of agricultural and food chemistry.

[7]  K. Tsim,et al.  A Chemically Standardized Extract of Ziziphus jujuba Fruit (Jujube) Stimulates Expressions of Neurotrophic Factors and Anti‐oxidant Enzymes in Cultured Astrocytes , 2014, Phytotherapy research : PTR.

[8]  D. Mbéguié-A-Mbéguié,et al.  Changes in antioxidant activity during the ripening of jujube (Ziziphus mauritiana Lamk). , 2014, Food chemistry.

[9]  H. Viernstein,et al.  Apoptosis of human breast cancer cells induced by microencapsulated betulinic acid from sour jujube fruits through the mitochondria transduction pathway. , 2013, Food Chemistry.

[10]  P. Tu,et al.  Characterization of water soluble polysaccharides from organs of Chinese Jujube (Ziziphus jujuba Mill. cv. Dongzao) , 2008 .

[11]  J. Wan,et al.  Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography. , 2008, Journal of pharmaceutical and biomedical analysis.

[12]  X. Ding,et al.  Comparison of antioxidant capacities of extracts from five cultivars of Chinese jujube , 2005 .

[13]  P. Tu,et al.  Structures and immunological activities of two pectic polysaccharides from the fruits of Ziziphus jujuba Mill. cv. jinsixiaozao Hort. , 2006 .

[14]  G. Grindey,et al.  Biochemical and antitumor effects of the combination of thymidine and 1-beta-D-arabinofuranosylcytosine against leukemia L1210. , 1981, Cancer research.

[15]  M. D'Archivio,et al.  Polyphenols, dietary sources and bioavailability. , 2007, Annali dell'Istituto superiore di sanita.

[16]  Pute Wu,et al.  Physico-chemical properties and antioxidant capacity of different jujube (Ziziphus jujuba Mill.) cultivars grown in loess plateau of China , 2011 .

[17]  S. P. Li,et al.  Effects of sample preparation methods on the quantification of nucleosides in natural and cultured Cordyceps. , 2008, Journal of pharmaceutical and biomedical analysis.

[18]  W. Willett,et al.  The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide , 2010, Nutrition journal.

[19]  J. Duan,et al.  Characterization of nucleosides and nucleobases in fruits of Ziziphus jujuba by UPLC-DAD-MS. , 2010, Journal of agricultural and food chemistry.

[20]  M. Ruiz-Méndez,et al.  Triterpenic acids in table olives , 2010 .

[21]  Xingbin Yang,et al.  Antioxidative and hepatoprotective effects of the polysaccharides from Zizyphus jujube cv. Shaanbeitanzao , 2012 .

[22]  D. Barrett,et al.  Advanced preservation methods and nutrient retention in fruits and vegetables. , 2012, Journal of the science of food and agriculture.

[23]  Irina Volf,et al.  A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables. , 2011, Food chemistry.

[24]  J. Conti,et al.  Endogenous adenosine is an antiarrhythmic agent. , 1995, Circulation.

[25]  C. Giordano,et al.  Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. , 2012, Journal of ethnopharmacology.

[26]  Qing-Han Gao,et al.  Effect of ripening stage on physicochemical properties and antioxidant profiles of a promising table fruit ‘pear-jujube’ (Zizyphus jujuba Mill.) , 2012 .

[27]  M. Fan,et al.  Distribution of phenolic acids in different tissues of jujube and their antioxidant activity. , 2011, Journal of agricultural and food chemistry.

[28]  Shaozhong Kang,et al.  Regulated deficit irrigation improved fruit quality and water use efficiency of pear-jujube trees , 2008 .

[29]  R. Nagai,et al.  Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages. , 2011, Journal of agricultural and food chemistry.

[30]  F. Ren,et al.  Systematic evaluation of antioxidant capacities of the ethanolic extract of different tissues of jujube (Ziziphus jujuba Mill.) from China. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[31]  K. Jacobson,et al.  Purine and pyrimidine (P2) receptors as drug targets. , 2002, Journal of medicinal chemistry.

[32]  Ting Yu,et al.  A combination of marine yeast and food additive enhances preventive effects on postharvest decay of jujubes (Zizyphus jujuba) , 2011 .

[33]  G. Yen,et al.  Effects of water-soluble carbohydrate concentrate from Chinese jujube on different intestinal and fecal indices. , 2008, Journal of agricultural and food chemistry.

[34]  Liuping Fan,et al.  Nutritional composition of five cultivars of chinese jujube , 2007 .

[35]  Jiankang Cao,et al.  ANTIOXIDANT ACTIVITY AND TOTAL PHENOLIC CONTENTS IN PEEL AND PULP OF CHINESE JUJUBE (ZIZIPHUS JUJUBA MILL) FRUITS , 2009 .

[36]  M. Friedman,et al.  Distribution of free amino acids, flavonoids, total phenolics, and antioxidative activities of Jujube (Ziziphus jujuba) fruits and seeds harvested from plants grown in Korea. , 2011, Journal of agricultural and food chemistry.

[37]  C. Hung,et al.  Antiproliferation of melanoma cells by polysaccharide isolated from Zizyphus jujuba. , 2012, Nutrition.

[38]  Jung-hee Kim,et al.  Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba. , 2004, Biological & pharmaceutical bulletin.

[39]  D. Lau,et al.  The Standardized Extract of Ziziphus jujuba Fruit (Jujube) Regulates Pro‐inflammatory Cytokine Expression in Cultured Murine Macrophages: Suppression of Lipopolysaccharide‐stimulated NF‐κB Activity , 2014, Phytotherapy research : PTR.

[40]  Helmut Viernstein,et al.  Comprehensive evaluation of natural antioxidants and antioxidant potentials in Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou fruits based on geographical origin by TOPSIS method , 2011 .

[41]  J. Quetin-Leclercq,et al.  HPLC quantification of two isomeric triterpenic acids isolated from Mitracarpus scaber and antimicrobial activity on Dermatophilus congolensis. , 2005, Journal of pharmaceutical and biomedical analysis.

[42]  S. Su,et al.  UHPLC-TOFMS coupled with chemometric method as a powerful technique for rapid exploring of differentiating components between two Ziziphus species. , 2011, Journal of separation science.

[43]  Qing-Han Gao,et al.  Effect of drying of jujubes ( Ziziphus jujuba Mill.) on the contents of sugars, organic acids, α-tocopherol, β-carotene, and phenolic compounds. , 2013, Journal of agricultural and food chemistry.

[44]  M. C. Gonzalez,et al.  Fatty Acids and Carotenes in Some Ber (Ziziphus jujuba Mill) Varieties , 2004, Plant foods for human nutrition.

[45]  B. Şan,et al.  Phenolic, alpha-tocopherol, beta-carotene and fatty acid composition of four promising jujube (Ziziphus jujuba Miller) selections , 2010 .

[46]  Jianbin Zheng,et al.  Simultaneous Determination of Six Phenolic Compounds in Jujube by LC-ECD , 2010 .

[47]  I. Russo,et al.  Adenosine increases human platelet levels of cGMP through nitric oxide: possible role in its antiaggregating effect. , 2002, Thrombosis research.

[48]  D. Lau,et al.  A standardized extract of the fruit of Ziziphus jujuba (Jujube) induces neuronal differentiation of cultured PC12 cells: a signaling mediated by protein kinase A. , 2014, Journal of agricultural and food chemistry.

[49]  Yihai Wang,et al.  Triterpenoids of sour jujube show pronounced inhibitory effect on human tumor cells and antioxidant activity. , 2014, Fitoterapia.

[50]  Y. Liu,et al.  Protection against carbon tetrachloride hepatotoxicity by oleanolic acid is not mediated through metallothionein. , 1998, Toxicology letters.

[51]  J. Finley,et al.  Antioxidants in foods: state of the science important to the food industry. , 2011, Journal of agricultural and food chemistry.

[52]  B. Demirci,et al.  Isomers of plamitoleic acid in lipids and volatile substances from the fruits ofZiziphus jujuba , 1999, Chemistry of Natural Compounds.

[53]  G. Qin,et al.  Effects of 1-methylcyclopropene(1-MCP) on ripening and resistance of jujube (Zizyphus jujuba cv. Huping) fruit against postharvest disease , 2012 .

[54]  K. Leung,et al.  Qualitative and quantitative analyses of nucleosides and nucleobases in Ganoderma spp. by HPLC-DAD-MS. , 2007, Journal of pharmaceutical and biomedical analysis.

[55]  G Burnstock,et al.  Receptors for purines and pyrimidines. , 1998, Pharmacological reviews.

[56]  I. Matsui‐yuasa,et al.  Effect of Zizyphus jujuba extract on the inhibition of adipogenesis in 3T3-L1 preadipocytes. , 2009, The American journal of Chinese medicine.

[57]  Liang Shan,et al.  Screening of a functional polysaccharide from Zizyphus Jujuba cv. Jinsixiaozao and its property. , 2011, International journal of biological macromolecules.

[58]  C. Szabó,et al.  Purines inhibit poly(ADP‐ribose) polymerase activation and modulate oxidant‐induced cell death , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[59]  T. Hasuma,et al.  Mechanism of the anti-cancer activity of Zizyphus jujuba in HepG2 cells. , 2007, The American journal of Chinese medicine.

[60]  Y. Fan,et al.  Phytochemical and antiinflammatory studies on Terminalia catappa. , 2004, Fitoterapia.

[61]  Manjeet Singh,et al.  Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat , 2011, Journal of Natural Medicines.

[62]  Tai-hui Fang,et al.  The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. , 2009, Journal of ethnopharmacology.

[63]  J. Quiles,et al.  The strawberry: composition, nutritional quality, and impact on human health. , 2012, Nutrition.

[64]  M. Ioannou,et al.  Nutritional evaluation and bioactive microconstituents (phytosterols, tocopherols, polyphenols, triterpenic acids) in cooked dry legumes usually consumed in the Mediterranean countries. , 2010 .

[65]  Y. Kho,et al.  Cytotoxic triterpenoids from the fruits of Zizyphus jujuba. , 2003, Planta medica.

[66]  A. Simopoulos,et al.  The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases , 2008, Experimental biology and medicine.

[67]  S. C. Chang,et al.  Structural characterization of polysaccharides from Zizyphus jujuba and evaluation of antioxidant activity. , 2010, International Journal of Biological Macromolecules.

[68]  D. Souza,et al.  Guanosine and GMP prevent seizures induced by quinolinic acid in mice , 2000, Brain Research.

[69]  T. Dong,et al.  The Extract of Ziziphus jujuba Fruit (Jujube) Induces Expression of Erythropoietin Via Hypoxia-Inducible Factor-1α in Cultured Hep3B Cells , 2014, Planta Medica.

[70]  Yuanfa Liu,et al.  Antioxidant activities of polysaccharides from the fruiting bodies of Zizyphus Jujuba cv. Jinsixiaozao , 2011 .

[71]  S. Su,et al.  High-performance liquid chromatography--two wavelength detection of triterpenoid acids from the fruits of Ziziphus jujuba containing various cultivars in different regions and classification using chemometric analysis. , 2009, Journal of pharmaceutical and biomedical analysis.

[72]  Liuping Fan,et al.  Isolation, purification and structure of a new water-soluble polysaccharide from Zizyphus jujuba cv. Jinsixiaozao , 2011 .

[73]  Songcheng Yu,et al.  The pretreatment effects on the antioxidant activity of jujube polysaccharides. , 2013, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[74]  Marita Hernández,et al.  Natural Triterpenic Diols Promote Apoptosis in Astrocytoma Cells through ROS-Mediated Mitochondrial Depolarization and JNK Activation , 2009, PloS one.

[75]  Bing Wang Chemical characterization and Ameliorating effect of polysaccharide from Chinese jujube on intestine oxidative injury by ischemia and reperfusion. , 2011, International journal of biological macromolecules.

[76]  Zhihong Xin,et al.  Effect of nano-packing on preservation quality of Chinese jujube (Ziziphus jujuba Mill. var. inermis (Bunge) Rehd) , 2009 .

[77]  F. Vahedi,et al.  Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study , 2008, Cytotechnology.