Chain Cdr3 Developmental Changes in the Human Heavy
暂无分享,去创建一个
P. Lipsky | G. Sims | M. Souto-Carneiro | Jisoo Lee | M. Lipsky | Peter E. Lee | Jisoo Girschik | Gary P Margarida Souto-Carneiro | Hermann Sims | Hermann Girschik
[1] R. Schelonka,et al. Development of the Expressed Ig CDR-H3 Repertoire Is Marked by Focusing of Constraints in Length, Amino Acid Use, and Charge That Are First Established in Early B Cell Progenitors1 , 2005, The Journal of Immunology.
[2] Jason M. Link,et al. Despite extensive similarity in germline DH and JH sequence, the adult Rhesus macaque CDR-H3 repertoire differs from human. , 2005, Molecular immunology.
[3] R. Jaenisch,et al. Direct in vivo VH to JH rearrangement violating the 12/23 rule , 2005, The Journal of experimental medicine.
[4] N. Rajewsky,et al. Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer , 2004, Cell.
[5] P. Lipsky,et al. Characterization of the Human Ig Heavy Chain Antigen Binding Complementarity Determining Region 3 Using a Newly Developed Software Algorithm, JOINSOLVER , 2004, The Journal of Immunology.
[6] Gregory A. Buck,et al. Partitioning of Rearranged Ig Genes by Mutation Analysis Demonstrates D-D Fusion and V Gene Replacement in the Expressed Human Repertoire1 , 2004, The Journal of Immunology.
[7] J. Engler,et al. Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures. , 2003, Journal of molecular biology.
[8] M. Nussenzweig,et al. Predominant Autoantibody Production by Early Human B Cell Precursors , 2003, Science.
[9] H. Sekine,et al. Effect of genetic deficiency of terminal deoxynucleotidyl transferase on autoantibody production and renal disease in MRL/lpr mice. , 2003, Clinical immunology.
[10] C. Berek,et al. Diversification of Ig Heavy Chain Genes in Human Preterm Neonates Prematurely Exposed to Environmental Antigens1 , 2002, The Journal of Immunology.
[11] T. Naoe,et al. B‐cell precursors differentiated from cord blood CD34+ cells are more immature than those derived from granulocyte colony‐stimulating factor‐mobilized peripheral blood CD34+ cells , 2001, Immunology.
[12] C. Milstein,et al. Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[13] H. Schroeder,et al. Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life. , 2001, Blood.
[14] H. Versmold,et al. The diversity of rearranged immunoglobulin heavy chain variable region genes in peripheral blood B cells of preterm infants is restricted by short third complementarity-determining regions but not by limited gene segment usage. , 2001, Blood.
[15] J. Sun,et al. Antibody Repertoire Development in Fetal and Neonatal Piglets. II. Characterization of Heavy Chain Complementarity-Determining Region 3 Diversity in the Developing Fetus1 2 , 2000, The Journal of Immunology.
[16] T. Paull,et al. A mechanistic basis for Mre11-directed DNA joining at microhomologies. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[17] F. E. Bertrand,et al. IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth. , 1999, Journal of immunology.
[18] T. Paull,et al. The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. , 1998, Molecular cell.
[19] A. Cumano,et al. Extensive junctional diversity of Ig heavy chain rearrangements generated in the progeny of single fetal multipotent hematopoietic cells in the absence of selection. , 1998, Journal of immunology.
[20] Baskin,et al. Characterization of the CDR3 region of rearranged α heavy chain genes in human fetal liver , 1998 .
[21] E L Sonnhammer,et al. Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, "minor" D segments or D-D recombination. , 1997, Journal of molecular biology.
[22] R. Brezinschek,et al. Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells. , 1997, The Journal of clinical investigation.
[23] T. Marion,et al. Correlation between the amino acid position of arginine in VH-CDR3 and specificity for native DNA among autoimmune antibodies. , 1996, Journal of immunology.
[24] E L Sonnhammer,et al. The imprint of somatic hypermutation on the repertoire of human germline V genes. , 1996, Journal of molecular biology.
[25] M. Milili,et al. The VDJ repertoire expressed in human preB cells reflects the selection of bona fide heavy chains , 1996, European journal of immunology.
[26] R. Zinkernagel,et al. Efficient immune responses in mice lacking N‐region diversity , 1995, European journal of immunology.
[27] M. Milili,et al. Fetal versus Adult PreB or B Cells: The Human VH Repertoire a , 1995, Annals of the New York Academy of Sciences.
[28] P. Nielsen,et al. In vitro generation of lymphoid precursors from embryonic stem cells. , 1994, The EMBO journal.
[29] C. Thompson,et al. Restricted immunoglobulin junctional diversity in neonatal B cells results from developmental selection rather than homology-based V(D)J joining , 1993, The Journal of experimental medicine.
[30] H. Yamagishi,et al. Biased reading frames of pre‐existing DH‐‐JH coding joints and preferential nucleotide insertions at VH‐‐DJH signal joints of excision products of immunoglobulin heavy chain gene rearrangements. , 1992, The EMBO journal.
[31] A. Feeney. Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies. , 1992, Journal of immunology.
[32] R. Schuurman,et al. Restricted utilization of germ‐line VH3 genes and short diverse third complementarity‐determining regions (CDR3) in human fetal B lymphocyte immunoglobulin heavy chain rearrangements , 1992, European journal of immunology.
[33] I. Sanz,et al. Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions. , 1991, Journal of immunology.
[34] I. Sanz,et al. Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires. , 1991, Journal of immunology.
[35] A. Feeney. Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences , 1990, The Journal of experimental medicine.
[36] J. Y. Wang,et al. Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[37] K. Rajewsky,et al. Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B‐CLL progenitor generation. , 1990, The EMBO journal.
[38] K. G. Nickerson,et al. Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements , 1989, The Journal of experimental medicine.
[39] R. Perlmutter,et al. Early restriction of the human antibody repertoire. , 1987, Science.
[40] F. Alt,et al. Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines , 1984, Nature.
[41] David Baltimore,et al. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells , 1984, Nature.
[42] H. Schroeder. Similarity and divergence in the development and expression of the mouse and human antibody repertoires. , 2006, Developmental and comparative immunology.
[43] R. Schelonka,et al. Regulation and chance in the ontogeny of B and T cell antigen receptor repertoires , 2002, Immunologic research.
[44] P. Lipsky,et al. Comparative characteristics of μ chain and α chain transcripts expressed by individual tonsil plasma cells , 2001 .
[45] P. Lipsky,et al. The VlJl Repertoire in Human Fetal Spleen: Evidence for Positive Selection and Extensive Receptor Editing , 2000 .
[46] C A Bona,et al. Repertoires of antigen receptors in Tdt congenitally deficient mice. , 1996, International reviews of immunology.
[47] A. Feeney. Comparison of junctional diversity in the neonatal and adult immunoglobulin repertoires. , 1992, International reviews of immunology.