Cell and tissue kinetics of the subependymal layer in mouse brain following heavy charged particle irradiation

The following studies investigate the cellular response and cell population kinetics of the subependymal layer in the mouse brain exposed to heavy charged particle irradiation. Partial brain irradiation with helium and neon ions was confined to one cortex of the brain. Both the irradiated and the unirradiated contralateral cortex showed similar disturbances of the cell and tissue kinetics in the subependymal layers. The irradiated hemisphere exhibited histological damage, whereas the unirradiated side appeared normal histologically. This study concerns the cell population and cell cycle kinetics of the subependymal layer in the mouse brain, and the effects of charged particle irradiations on this cell population. Quantitative high resolution autoradiography was used to study the kinetic parameters in this cell layer. This study should help in understanding the effects of these high-energy heavy ions on normal mammalian brain tissue. The response of the mammalian brain exposure to charged particle ionizing radiation may be extremely variable. It varies from minimal physiological changes to overt tissue necrosis depending on a number of factors such as: the administered dose, dose-rate, the volume of the irradiated tissue, and the biological end-point being examined.

[1]  J. Fabrikant.  Adaptation of cell renewal systems under continuous irradiation. , 1987, Health physics.

[2]  K. Frankel,et al.  A helium-ion beam for stereotactic radiosurgery of central nervous system disorders. , 1986, Medical physics.

[3]  H. Korr,et al.  Cell Kinetic Studies of Different Cell Types In the Developing and Adult Brain of the Rat and the Mouse: A Review , 1981, Cell and tissue kinetics.

[4]  C. Tobias,et al.  BIOLOGICAL AND MEDICAL RESEARCH WITH ACCELERATED HEAVY IONS AT THE BEVALAC. 1977-1980 , 1980 .

[5]  J. Jett,et al.  Differences in cell-cycle progression delays after exposure to 238Pu alpha particles compared to X rays. , 1980, Radiation research.

[6]  J. Hopewell,et al.  QUANTITATIVE CHANGES IN THE CELLULARITY OF THE RAT SUBEPENDYMAL PLATE AFTER X‐IRRADIATION , 1980, Cell and tissue kinetics.

[7]  J. Lyman,et al.  Inactivation of human kidney cells by high-energy monoenergetic heavy-ion beams. , 1979, Radiation research.

[8]  E. Blakely,et al.  Drastic G2 arrest in mammalian cells after irradiation with heavy-ion beams. , 1979, Radiation research.

[9]  A. Patel,et al.  Effect of undernutrition on cell generation in the adult rat brain , 1977, Brain Research.

[10]  E. Hall,et al.  Biophysical studies with high-energy argon ions 2. Determinations of the relative biological effectiveness, the oxygen enhancement ratio, and the cell cycle response. , 1977, Radiation research.

[11]  S. B. Field,et al.  The effects of fast neutrons and X rays on the subependymal layer of the rat brain. , 1977, Radiology.

[12]  C. Gilbert,et al.  A COMPARISON OF COMPUTER METHODS FOR THE ANALYSIS OF FRACTION LABELLED MITOSES CURVES , 1975, Cell and tissue kinetics.

[13]  P. D. Lewis.  CELL DEATH IN THE GERMINAL LAYERS OF THE POSTNATAL RAT BRAIN , 1975 .

[14]  A. J. van der Kogel,et al.  Late effects of spinal cord irradiation with 300 kV X rays and 15 MeV neutrons. , 1974, The British journal of radiology.

[15]  C. Tobias.  Pretherapeutic investigations with accelerated heavy ions. , 1973, Radiology.

[16]  C. P. Leblond,et al.  Investigation of glial cells in semithin sections. III. Transformation of subependymal cells into glial cells, as shown by radioautography after 3H‐thymidine injection into the lateral ventricle of the brain of young rats , 1973, The Journal of comparative neurology.

[17]  M. Mendelsohn,et al.  The Automatic Analysis of Flm Curves , 1971, Cell and tissue kinetics.

[18]  M. Tubiana.  The kinetics of tumour cell proliferation and radiotherapy. , 1971, The British journal of radiology.

[19]  P. D. M. Macdonald,et al.  Statistical inference from the fraction labelled mitoses curve , 1970 .

[20]  E. A. Wright,et al.  The nature of latent cerebral irradiation damage and its modification by hypertension. , 1970, The British journal of radiology.

[21]  J. Fried.  Mean, geometric mean, or median grain count in cell cycle studies. , 1970, Experimental cell research.

[22]  B. V. Bronk,et al.  The stochastic theory of cell proliferation. , 1968, Biophysical journal.

[23]  P. D. Lewis.  A quantitative study of cell proliferation in the subependymal layer of the adult rat brain. , 1968, Experimental neurology.

[24]  M Takahashi,et al.  Theoretical basis for cell cycle analysis: II. Further studies on labelled mitosis wave method. , 1968, Journal of theoretical biology.

[25]  E. A. Wright,et al.  Effect of Previous X-irradiation on the Response of Brain to Injury , 1967, Nature.

[26]  J. Fabrikant.  The effect of prior continuous irradiation on the G2, M, and S phases of proliferating parenchymal cells in the regenerating liver. , 1967, Radiation research.

[27]  J. C. Barrett.  A mathematical model of the mitotic cycle and its application to the interpretation of percentage labeled mitoses data. , 1966, Journal of the National Cancer Institute.

[28]  G. Steel.  Delayed Uptake by Tumours of Tritium from Thymidine , 1966, Nature.

[29]  M. Rajewsky,et al.  In vitro studies of cell proliferation in tumours. II. Characteristics of a standardised in vitro system for the measurement of 3H-thymidine incorporation into tissue explants. , 1965, European journal of cancer.

[30]  A. Cairnie,et al.  Cell proliferation studies in the intestinal epithelium of the rat. I. Determination of the kinetic parameters. , 1965, Experimental cell research.

[31]  S. R. Pelc.  LABELLING OF DNA AND CELL DIVISION IN SO CALLED NON-DIVIDING TISSUES , 1964, The Journal of cell biology.

[32]  S. Gelfant.  PATTERNS OF EPIDERMAL CELL DIVISION. I. GENETIC BEHAVIOR OF THE G1-CELL POPULATION. , 1963, Experimental cell research.

[33]  E. A. Evans,et al.  Stability of Thymidine Labelled with Tritium or Carbon-14 , 1963, Nature.

[34]  R. Baserga,et al.  The kinetics of growth of the Ehrlich tumor. A comparative study of the kinetics of cellular proliferation with the use of tritiated thymidine. , 1963, Archives of pathology.

[35]  G. Whitmore,et al.  Comparative effects of neutrons and x-rays on mammalian cells. , 1963, Radiation research.

[36]  R. Brownson,et al.  Acute brain damage induced by low dosage x‐irradiation , 1963, Neurology.

[37]  P. Reichard.  Enzymatic synthesis of deoxyribonucleotides. I. Formation of deoxycytidine diphosphate from cytidine diphosphate with enzymes from Escherichia coli. , 1962, The Journal of biological chemistry.

[38]  M. Mendelsohn.  Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. III. The growth fraction. , 1962, Journal of the National Cancer Institute.

[39]  S. Gelfant,et al.  Initiation of mitosis in relation to the cell division cycle. , 1962, Experimental cell research.

[40]  C. Richmond,et al.  Comparative metabolism of tritiated water by mammals. , 1962, Journal of cellular and comparative physiology.

[41]  L. Lajtha,et al.  Cell population kinetics following different regimes of irradiation. , 1962, The British journal of radiology.

[42]  P. Alexander.  Mouse Lymphoma Cells with Different Radiosensitivities , 1961, Nature.

[43]  P. Timiras,et al.  Changes in brain excitability after whole-body x-irradiation in the rat. , 1961, Radiation research.

[44]  C. P. Baker,et al.  The design and calibration of a deuteron microbeam for biological studies. , 1961, Radiation research.

[45]  C. P. Baker,et al.  Histopathologic effect of high-energy-particle microbeams on the visual cortex of the mouse brain. , 1961, Radiation research.

[46]  C. P. Leblond,et al.  Evidence for division and transformations of neuroglia cells in the mouse brain, as derived from radioautography after injection of thymidine‐H3 , 1961 .

[47]  H. Quastler.  CELL POPULATION KINETICS * , 1960, Annals of the New York Academy of Sciences.

[48]  H. Curtis,et al.  Tolerance of Mouse-Brain Tissue to High-Energy Deuterons , 1959, Science.

[49]  H QUASTLER,et al.  Cell population kinetics in the intestinal epithelium of the mouse. , 1959, Experimental cell research.

[50]  N. Berg,et al.  Book Review: Time-Dose Relationship and Morphology of Delayed Radiation Lesions of the Brain in Rabbits , 1959, Acta radiologica. Supplementum.

[51]  E. Alpen,et al.  OBSERVATIONS ON REGULATION OF ERYTHROPOIESIS AND ON CELLULAR DYNAMICS BY Fe$sup 59$ AUTORADIOGRAPHY , 1959 .

[52]  J. Storer,et al.  The relative biological effectiveness of various ionizing radiations in mammalian systems. , 1957, Radiation research.

[53]  D. B. Cater,et al.  Cell division and nucleic acid synthesis in the regenerating liver of the rat. , 1956, Acta radiologica.

[54]  R. A. Harvey,et al.  Intolerance of the Primate Brainstem and Hypothalamus to Conventional and High Energy Radiations , 1954, Neurology.

[55]  H. Kuhlenbeck,et al.  THE SUBEPENDYMAL CELL PLATE (MATRIX) AND ITS RELATIONSHIP TO BRAIN TUMORS OF THE EPENDYMAL TYPE , 1944 .

[56]  W. Scholz,et al.  LATE DAMAGE FROM ROENTGEN IRRADIATION OF THE HUMAN BRAIN , 1938 .

[57]  J. O'connell,et al.  OBSERVATIONS ON THE ROENTGEN TREATMENT OF INTRACRANIAL GLIOMATA WITH ESPECIAL REFERENCE TO THE EFFECTS OF IRRADIATION UPON THE SURROUNDING BRAIN , 1937 .

[58]  A. Howard,et al.  Synthesis of Desoxyribonucleic Acid in Normal and Irradiated Cells and Its Relation to Chromosome Breakage , 1986 .

[59]  C. Lücke‐Huhle,et al.  The influence of ionization density on the DNA synthetic phase and survival of irradiated mammalian cells. , 1981, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[60]  A. Valleron,et al.  Comparative effects of 60Co gamma-rays and neon and helium ions on cycle duration and division probability of EMT 6 cells. A time-lapse cinematography study. , 1981, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[61]  Dr. H. Korr.  Proliferation of Different Cell Types in the Brain , 1980, Advances in Anatomy Embryology and Cell Biology.

[62]  J. Quivey,et al.  Clinical experience and expectations with helium and heavy ion irradiation. , 1977, International journal of radiation oncology, biology, physics.

[63]  W. Caveness.  Pathology of radiation damage to the normal brain of the monkey. , 1977, National Cancer Institute monograph.

[64]  M. M. Elkind,et al.  Comparative radiobiology of fast neutrons: relevance to radiotherapy and basic studies. , 1977, International journal of radiation oncology, biology, physics.

[65]  J. Lyman,et al.  Dosimetry and instrumentation for helium and heavy ions. , 1977, International journal of radiation oncology, biology, physics.

[66]  S. Elam.  Biological and medical research with accelerated heavy ions at the Bevalac, 1974-1977 , 1977 .

[67]  H. Burki,et al.  Survival of synchronized Chinese hamster cells exposed to radiation of different linear-energy transfer. , 1975, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[68]  B. S. Neporent,et al.  On The Mechanism of , 1975 .

[69]  M. Wender,et al.  Icorporation of [3H] thymidine into neuroglial cells in the course of myelinogenesis. , 1974, Folia histochemica et cytochemica.

[70]  J. Cavanagh,et al.  Effects of X irradiation on the mitotic activity of the subependymal plate of rats. , 1972, The British journal of radiology.

[71]  J. Lyman,et al.  Some considerations of physical and biological factors in radiotherapy with high-LET radiations including heavy particles, pi mesons, and fast neutrons. , 1971, Progress in atomic medicine.

[72]  T. Samorajski,et al.  EFFECTS OF IRRADIATION ON THE NERVOUS SYSTEM. , 1971 .

[73]  N. D. Gracheva.  [Autoradiographic study of the proliferative activity of subependymal cells in the rat's brain]. , 1969, Tsitologiia.

[74]  H. Bichsel.  4 – HARGED-PARTICLE INTERACTIONS , 1968 .

[75]  P. Todd,et al.  Heavy charged particles in cancer therapy. , 1967, National Cancer Institute monograph.

[76]  島田 司己.  Cytokinetics and histogenesis of early postnatal mouse brain as studied by 3H-thymidine autoradiography , 1966 .

[77]  W. Zeman.  PATHOGENESIS OF RADIOLESIONS IN THE MATURE CENTRAL NERVOUS SYSTEM , 1965 .

[78]  L. Tolmach,et al.  Variations in several responses of HeLa cells to x-irradiation during the division cycle. , 1963, Biophysical journal.

[79]  L. Lamerton.  Late effects of continuous irradiation. , 1963, Laval medical.

[80]  M L Mendelsohn,et al.  The growth fraction, a new concept applied to tumors. Abstr. , 1960 .

[81]  F. Vogel,et al.  The induction of acute morphological changes in the central nervous system and pituitary body of macaque monkeys by cobalt60 (gamma) radiation. , 1958, Journal of neuropathology and experimental neurology.

[82]  K. E. Leigh,et al.  Time-intensity factors in radiation response. I. The acute effects of megavolt electrons (cathode rays) and high- and low-energy x-rays; with special reference to the brain. , 1956, A.M.A. archives of pathology.

[83]  R. S. Lyman,et al.  EFFECT OF ROENTGEN RAYS ON THE CENTRAL NERVOUS SYSTEM: RESULTS OF LARGE DOSES ON THE BRAINS OF ADULT DOGS , 1933 .