Combined small cell carcinoma and clear cell carcinoma of the gallbladder: report of a case and review of the literature.

We report a case of an incidental combined carcinoma of the gallbladder in a 66-year-old woman who underwent cholecistectomy for gallstones. The neoplasm was mainly constituted by a clear cell component and a small cell, chromogranin-positive one; it also showed some areas of conventional adenocarcinoma and foci of vascular invasion. The patient died after 3 years following treatment with combination chemotherapy. The histologic and immunohistochemical profile of the lesion is described, together with a brief review of the pertinent bibliography.

[1]  T. Aotake,et al.  Small cell carcinoma of the gallbladder: a case report and review of 53 cases in the literature. , 2001, Hepato-gastroenterology.

[2]  R. Hruban,et al.  Small Cell Carcinoma of the Gallbladder: A Clinicopathologic, Immunohistochemical, and Molecular Pathology Study of 12 Cases , 2001, The American journal of surgical pathology.

[3]  D. Henson,et al.  Tumors of the Gallbladder, Extrahepatic Bile Ducts and Ampulla of Vater , 2000 .

[4]  T. Kanematsu,et al.  Small-Cell Carcinoma of the Gallbladder: Report of a Case , 2000, Surgery Today.

[5]  S. Chuang,et al.  Small cell carcinoma of the gallbladder: Report of two cases , 1999, Pathology & Oncology Research.

[6]  H. Nava,et al.  Small cell carcinoma of the gallbladder , 1999, Journal of surgical oncology.

[7]  H. Kuwabara,et al.  Small cell carcinoma of the gall‐bladder with intestinal metaplastic epithelium , 1998, Pathology international.

[8]  R. Tank,et al.  Small cell carcinoma of gallbladder: report of two cases. , 1996, The American journal of gastroenterology.

[9]  P. Barth,et al.  Clear cell carcinoma of the gallbladder. A histological and immunohistochemical study. , 1995, Pathology, research and practice.

[10]  J. Albores–Saavedra,et al.  Clear cell carcinomas of the gallbladder and extrahepatic bile ducts. , 1995, The American journal of surgical pathology.

[11]  M. Tsuneyoshi,et al.  Small-cell carcinoma combined with adenocarcinoma of the gallbladder. A case report with immunohistochemical and flow cytometric studies. , 1994, Archives of pathology & laboratory medicine.

[12]  Johnstone Ak,et al.  Oat cell carcinoma of the gallbladder. A rare and highly lethal neoplasm. , 1993 .

[13]  S. Chaitchik,et al.  Small Cell Carcinoma of the Gallbladder: Clinical Course and Response to Chemotherapy , 1992, Tumori.

[14]  Y. Tsutsumi,et al.  Small Cell (Endocrine Cell) Carcinoma of the Gallbladder with Squamous and Adenocarcinomatous Components , 1992, Acta pathologica japonica.

[15]  H. Shigematsu,et al.  Small Cell Carcinoma of the Gallbladder Combined with Adenocarcinoma , 1991, Acta pathologica japonica.

[16]  J. Pedersen,et al.  Endocrine cell carcinoma of the gallbladder , 1991, Histopathology.

[17]  A. Fassina,et al.  Small-cell carcinoma of gallbladder. An immunocytochemical and ultrastructural study. , 1991, Pathology, research and practice.

[18]  L. Sobin,et al.  Histological Typing of Tumours of the Gallbladder and Extrahepatic Bile Ducts , 1991, World Health Organization. International Histological Classification of Tumours.

[19]  P. George,et al.  Combined endocrine cell carcinoma and adenocarcinoma of the gallbladder , 1990, Histopathology.

[20]  Nagorney Dm,et al.  Carcinoma of the gallbladder and extrahepatic bile ducts. , 1988 .

[21]  D. Henson,et al.  Unusual types of gallbladder carcinoma. A report of 16 cases. , 1981, Archives of pathology & laboratory medicine.