Negation Scope Delimitation in Clinical Text Using Three Approaches: NegEx, PyConTextNLP and SynNeg

Negation detection is a key component in clinical information extraction systems, as health record text contains reasonings in which the physician excludes different diagnoses by negating them. Many systems for negation detection rely on negation cues (e.g. not), but only few studies have investigated if the syntactic structure of the sentences can be used for determining the scope of these cues. We have in this paper compared three different systems for negation detection in Swedish clinical text (NegEx, PyConTextNLP and SynNeg), which have different approaches for determining the scope of negation cues. NegEx uses the distance between the cue and the disease, PyConTextNLP relies on a list of conjunctions limiting the scope of a cue, and in SynNeg the boundaries of the sentence units, provided by a syntactic parser, limit the scope of the cues. The three systems produced similar results, detecting negation with an F-score of around 80%, but using a parser had advantages when handling longer, complex sentences or short sentences with contradictory statements.

[1]  Ola Knutsson,et al.  A Robust Shallow Parser for Swedish , 2003 .

[2]  Wendy W. Chapman,et al.  Document-level classification of CT pulmonary angiography reports based on an extension of the ConText algorithm , 2011, J. Biomed. Informatics.

[3]  Yang Huang,et al.  A novel hybrid approach to automated negation detection in clinical radiology reports. , 2007, Journal of the American Medical Informatics Association : JAMIA.

[4]  W. Bruce Croft,et al.  Research Paper: Ad Hoc Classification of Radiology Reports , 1999, J. Am. Medical Informatics Assoc..

[5]  Sumithra Velupillai,et al.  Something Old, Something New - Applying a Pre-trained Parsing Model to Clinical Swedish , 2011, NODALIDA.

[6]  Roser Morante,et al.  *SEM 2012 Shared Task: Resolving the Scope and Focus of Negation , 2012, *SEMEVAL.

[7]  Yuji Matsumoto MaltParser: A language-independent system for data-driven dependency parsing , 2005 .

[8]  Stephan Oepen,et al.  Speculation and Negation: Rules, Rankers, and the Role of Syntax , 2012, CL.

[9]  Virginia Francisco,et al.  Inferring the Scope of Negation in Biomedical Documents , 2012, CICLing.

[10]  Peter L. Elkin,et al.  A controlled trial of automated classification of negation from clinical notes , 2005, BMC Medical Informatics Decis. Mak..

[11]  Long H. Ngo,et al.  Implementation and Evaluation of Four Different Methods of Negation Detection , 2007 .

[12]  Wendy W. Chapman,et al.  Evaluation of negation phrases in narrative clinical reports , 2001, AMIA.

[13]  Wendy W. Chapman,et al.  A Simple Algorithm for Identifying Negated Findings and Diseases in Discharge Summaries , 2001, J. Biomed. Informatics.

[14]  Wendy W. Chapman,et al.  ConText: An algorithm for determining negation, experiencer, and temporal status from clinical reports , 2009, J. Biomed. Informatics.

[15]  Lior Rokach,et al.  Negation recognition in medical narrative reports , 2008, Information Retrieval.

[16]  Roser Morante,et al.  Learning the Scope of Hedge Cues in Biomedical Texts , 2009, BioNLP@HLT-NAACL.

[17]  Maria Skeppstedt,et al.  Negation detection in Swedish clinical text: An adaption of NegEx to Swedish , 2011, J. Biomed. Semant..

[18]  Danielle L. Mowery,et al.  Porting a Rule-based Assertion Classifier for Clinical Text from English to Swedish , 2013 .

[19]  Maria Kvist,et al.  Factuality Levels of Diagnoses in Swedish Clinical Text , 2011, MIE.

[20]  Prakash M. Nadkarni,et al.  Research Paper: Use of General-purpose Negation Detection to Augment Concept Indexing of Medical Documents: A Quantitative Study Using the UMLS , 2001, J. Am. Medical Informatics Assoc..

[21]  Guodong Zhou,et al.  A Unified Framework for Scope Learning via Simplified Shallow Semantic Parsing , 2010, EMNLP.