Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans.

Tryptophan, serotonin, and melatonin, present in Jerte Valley cherries, participate in sleep regulation and exhibit antioxidant properties. The effect of the intake of seven different Jerte Valley cherry cultivars on the sleep-wake cycle, 6-sulfatoxymelatonin levels, and urinary total antioxidant capacity in middle-aged and elderly participants was evaluated. Volunteers were subjected to actigraphic monitoring to record and display the temporal patterns of their nocturnal activity and rest. 6-sulfatoxymelatonin and total antioxidant capacity were quantified by enzyme-linked immunosorbent assay and colorimetric assay kits, respectively. The intake of each of the cherry cultivars produced beneficial effects on actual sleep time, total nocturnal activity, assumed sleep, and immobility. Also, there were significant increases in 6-sulfatoxymelatonin levels and total antioxidant capacity in urine after the intake of each cultivar. These findings suggested that the intake of Jerte Valley cherries exerted positive effect on sleep and may be seen as a potential nutraceutical tool to counteract oxidation.

[1]  R. Hardeland,et al.  Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms , 2003, Chronobiology international.

[2]  R. Reiter,et al.  Tryptophan modulates cell viability, phagocytosis and oxidative metabolism in old ringdoves. , 2007, Basic & clinical pharmacology & toxicology.

[3]  R. Reiter,et al.  Detection and quantification of the antioxidant melatonin in Montmorency and Balaton tart cherries (Prunus cerasus). , 2001, Journal of agricultural and food chemistry.

[4]  R. Reiter,et al.  Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin , 2009, Critical reviews in biochemistry and molecular biology.

[5]  N. Seeram,et al.  Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cells. , 2003, Cancer letters.

[6]  C. Ferrari.  Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging , 2004, Biogerontology.

[7]  F. Badria.  Melatonin, serotonin, and tryptamine in some egyptian food and medicinal plants. , 2002, Journal of medicinal food.

[8]  D. Kripke,et al.  Circadian abnormalities in older adults , 2001, Journal of pineal research.

[9]  P. Schuff-Werner,et al.  Antioxidative properties of serotonin and the bactericidal function of polymorphonuclear phagocytes. , 1999, Advances in Experimental Medicine and Biology.

[10]  I. Macháčková,et al.  Melatonin in higher plants: occurrence and possible functions , 2005, Journal of pineal research.

[11]  M. Nair,et al.  Antioxidant polyphenols from tart cherries (Prunus cerasus). , 1999, Journal of agricultural and food chemistry.

[12]  M. Leboyer,et al.  Mid-morning Tryptophan Depletion Delays REM Sleep Onset in Healthy Subjects , 2002, Neuropsychopharmacology.

[13]  D. Kunz,et al.  Normative data on the daily profile of urinary 6-sulfatoxymelatonin in healthy subjects between the ages of 20 and 84 , 2006, Psychoneuroendocrinology.

[14]  R. Reiter,et al.  Effect of exogenous melatonin on viability, ingestion capacity, and free-radical scavenging in heterophils from young and old ringdoves (Streptopelia risoria) , 2007, Molecular and Cellular Biochemistry.

[15]  A. Rodriguez,et al.  A nutraceutical product based on Jerte Valley cherries improves sleep and augments the antioxidant status in humans , 2009 .

[16]  J. Ehlen,et al.  Dorsal raphe nuclear stimulation of SCN serotonin release and circadian phase-resetting , 2000, Brain Research.

[17]  C. Nagata,et al.  Consumption of vegetables alters morning urinary 6‐sulfatoxymelatonin concentration , 2008, Journal of pineal research.

[18]  Nava Zisapel,et al.  Melatonin and Sleep , 2010 .

[19]  S. Cuzzocrea,et al.  Individual and synergistic antioxidative actions of melatonin: studies with vitamin E, vitamin C, glutathione and desferrrioxamine (desferoxamine) in rat liver homogenates , 2001, The Journal of pharmacy and pharmacology.

[20]  M. Iriti.  Melatonin in grape, not just a myth, maybe a panacea , 2009, Journal of pineal research.

[21]  D. González-Gómez,et al.  Detection and quantification of melatonin and serotonin in eight Sweet Cherry cultivars (Prunus avium L.) , 2009 .

[22]  R. Reiter,et al.  Melatonin in edible plants (phytomelatonin): Identification, concentrations, bioavailability and proposed functions. , 2007, World review of nutrition and dietetics.

[23]  R. Ortega.  Importance of functional foods in the Mediterranean diet , 2006, Public Health Nutrition.

[24]  R. Rial,et al.  Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[25]  D. González-Gómez,et al.  Sweet cherry phytochemicals: Identification and characterization by HPLC-DAD/ESI-MS in six sweet-cherry cultivars grown in Valle del Jerte (Spain) , 2010 .

[26]  C. Barriga,et al.  Assays of the Amino Acid Tryptophan in Cherries by HPLC-Fluorescence , 2010 .

[27]  F. Peyrot,et al.  Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species , 2008, Journal of pineal research.

[28]  D. Williams,et al.  The serotonin transporter: a primary target for antidepressant drugs , 1998, Journal of psychopharmacology.

[29]  M. Iriti,et al.  Grape phytochemicals: a bouquet of old and new nutraceuticals for human health. , 2006, Medical hypotheses.

[30]  Chang Yong Lee,et al.  Sweet and sour cherry phenolics and their protective effects on neuronal cells. , 2005, Journal of agricultural and food chemistry.

[31]  S. Steinlechner,et al.  Creatinine is an appropriate reference for urinary sulphatoxymelatonin of laboratory animals and humans , 1997, Journal of pineal research.

[32]  R. Reiter,et al.  Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood. , 2005, Nutrition.

[33]  R. Reiter,et al.  Comparative Study of the Activity/Rest Rhythms in Young and Old Ringdove (Streptopelia Risoria): Correlation with Serum Levels of Melatonin and Serotonin , 2006, Chronobiology international.

[34]  R. Reiter,et al.  Tryptophan increases nocturnal rest and affects melatonin and serotonin serum levels in old ringdove , 2007, Physiology & Behavior.

[35]  B. Mackey,et al.  Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. , 2006, The Journal of nutrition.

[36]  R. Reiter,et al.  Phytomelatonin: a review. , 2009, Journal of experimental botany.

[37]  R. Reiter,et al.  Melatonin combats molecular terrorism at the mitochondrial level , 2008, Interdisciplinary toxicology.

[38]  D. Chan,et al.  Hippocampal, but not parahippocampal, damage in a case of dense retrograde amnesia: a pathological study , 2002, Neuroscience Letters.

[39]  C. Nagata,et al.  Association of Vegetable Intake with Urinary 6-Sulfatoxymelatonin Level , 2005, Cancer Epidemiology Biomarkers & Prevention.

[40]  R. Reiter,et al.  Melatonin in relation to the "strong" and "weak" versions of the free radical theory of aging. , 2008, Advances in medical sciences.

[41]  H. Steinhart,et al.  Determination of free and conjugated indole-3-acetic acid, tryptophan, and tryptophan metabolites in grape must and wine. , 2001, Journal of agricultural and food chemistry.