CXCR4 antibody treatment suppresses metastatic spread to the lung of intratibial human osteosarcoma xenografts in mice

[1]  B. Fuchs,et al.  LacZ transgene expression in the subcutaneous Dunn/LM8 osteosarcoma mouse model allows for the identification of micrometastasis , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[2]  Ping Chen,et al.  Relationships between levels of CXCR4 and VEGF and blood-borne metastasis and survival in patients with osteosarcoma , 2011, Medical oncology.

[3]  M. Joyce,et al.  Bone sarcomas: Overview of management, with a focus on surgical treatment considerations , 2010, Cleveland Clinic Journal of Medicine.

[4]  Paula D. Bos,et al.  Metastasis: from dissemination to organ-specific colonization , 2009, Nature Reviews Cancer.

[5]  W. Tap,et al.  The Multidisciplinary Management of Osteosarcoma , 2009, Current treatment options in oncology.

[6]  F. Baleux,et al.  The CXCL12γ Chemokine Displays Unprecedented Structural and Functional Properties that Make It a Paradigm of Chemoattractant Proteins , 2008, PloS one.

[7]  C. Napoli,et al.  Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. , 2008, Cancer research.

[8]  L. Helman,et al.  Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases , 2007, Clinical & Experimental Metastasis.

[9]  R. Gräsbeck,et al.  Osteosarcoma (Osteogenic sarcoma) , 2007, Orphanet journal of rare diseases.

[10]  S. Bielack,et al.  Current strategies of chemotherapy in osteosarcoma , 2006, International Orthopaedics.

[11]  Y. Iwamoto,et al.  CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis , 2006, Modern Pathology.

[12]  S. Smeland,et al.  Hematogenous Micrometastases in Osteosarcoma Patients , 2005, Clinical Cancer Research.

[13]  A. Huvos,et al.  Messenger RNA Expression Levels of CXCR4 Correlate with Metastatic Behavior and Outcome in Patients with Osteosarcoma , 2005, Clinical Cancer Research.

[14]  W. Piacibello,et al.  Involvement of chemokine receptor 4/stromal cell-derived factor 1 system during osteosarcoma tumor progression. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[15]  F. Balkwill.  Cancer and the chemokine network , 2004, Nature Reviews Cancer.

[16]  F. Balkwill.  The significance of cancer cell expression of the chemokine receptor CXCR4. , 2004, Seminars in cancer biology.

[17]  P. Meltzer,et al.  Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[18]  Tanja Hartmann,et al.  Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells , 2003, Oncogene.

[19]  Ying-hua Chen,et al.  Antibody to CD14 like CXCR4-specific antibody 12G5 could inhibit CXCR4-dependent chemotaxis and HIV Env-mediated cell fusion. , 2003, Immunology letters.

[20]  M. Ratajczak,et al.  CXCR4–SDF-1 Signalling, Locomotion, Chemotaxis and Adhesion , 2003, Journal of Molecular Histology.

[21]  F. Balkwill.  Chemokine biology in cancer. , 2003, Seminars in immunology.

[22]  V. Robert-Hebmann,et al.  Role of the intracellular domains of CXCR4 in SDF-1-mediated signaling. , 2003, Blood.

[23]  N. Jaffe,et al.  Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery? , 2002, Cancer.

[24]  Giovanni Martinelli,et al.  CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma. , 2002, Cancer research.

[25]  Evan T Keller,et al.  Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. , 2002, Cancer research.

[26]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[27]  M. Ratajczak,et al.  Binding of stromal derived factor‐1α(SDF‐1α) to CXCR4 chemokine receptorin normal human megakaryoblasts butnot in platelets induces phosphorylationof mitogen‐activated protein kinase p42/44 (MAPK), ELK‐1 transcription factor and serine/threonine kinase AKT , 2000, European journal of haematology.

[28]  R. Bronson,et al.  Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[29]  H. Kimura,et al.  Prognosis of Osteosarcoma With Pulmonary Metastases at Initial Presentation Is Not Dismal , 1998, Clinical orthopaedics and related research.

[30]  R. Doms,et al.  CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4 , 1996, Cell.

[31]  S. Nishikawa,et al.  Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 , 1996, Nature.

[32]  A. Krüger,et al.  Scattered micrometastases visualized at the single‐cell level: Detection and re‐isolation of lacZ‐labeled metastasized lymphoma cells , 1994, International journal of cancer.

[33]  W. Akeson,et al.  Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice. , 1993, Cancer research.

[34]  P. Picci,et al.  The management of malignant bone tumors in children and adolescents. , 1991, Clinical Orthopaedics and Related Research.

[35]  J. Rhim,et al.  Transformation of human osteosarcoma cells by a chemical carcinogen. , 1975, Journal of the National Cancer Institute.

[36]  J. Rhim,et al.  Non‐producer human cells induced by murine sarcoma virus , 1975, International journal of cancer.

[37]  S. Ferrari,et al.  Pattern of relapse in patients with osteosarcoma of the extremities treated with neoadjuvant chemotherapy. , 2001, European journal of cancer.