Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

[1]  M. Frydman,et al.  Tissue distribution of cold-induced thermogenesis in conscious warm- or cold-acclimated rats reevaluated from changes in tissue blood flow: the dominant role of brown adipose tissue in the replacement of shivering by nonshivering thermogenesis. , 1979, Canadian journal of physiology and pharmacology.

[2]  J. Flatt,et al.  Effect of dietary fat content on the incidence of obesity among ad libitum fed mice. , 1985, International journal of obesity.

[3]  I. Maxwell,et al.  Regulated expression of a diphtheria toxin A-chain gene transfected into human cells: possible strategy for inducing cancer cell suicide. , 1986, Cancer research.

[4]  G. Bray,et al.  Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. , 1979, Physiological reviews.

[5]  S. Ma,et al.  Starvation-induced changes in metabolic rate, blood flow, and regional energy expenditure in rats. , 1986, Canadian journal of physiology and pharmacology.

[6]  T. R. Davis,et al.  Regulation of shivering and non-shivering heat production during acclimation of rats. , 1960, The American journal of physiology.

[7]  M. Mattéi,et al.  Molecular characterization of the mouse beta 3‐adrenergic receptor: relationship with the atypical receptor of adipocytes. , 1991, The EMBO journal.

[8]  R. Palmiter,et al.  Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene , 1987, Cell.

[9]  L. Tsui,et al.  Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. , 1987, Science.

[10]  M. Dutia,et al.  Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent. , 1992, Journal of medicinal chemistry.

[11]  J. Venter,et al.  An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity. , 1991, The Journal of biological chemistry.

[12]  I. Maxwell,et al.  Genetic ablation in transgenic mice with an attenuated diphtheria toxin A gene , 1990, Molecular and cellular biology.

[13]  L. Casteilla,et al.  The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. , 1991, The International journal of biochemistry.

[14]  J. Himms-Hagen,et al.  Brown adipose tissue thermogenesis and obesity. , 1989, Progress in lipid research.

[15]  P. Trayhurn,et al.  Brown adipose tissue thermogenesis in obese animals. , 1986, Biochemical Society transactions.

[16]  D. Nicholls,et al.  Thermogenic mechanisms in brown fat. , 1984, Physiological reviews.

[17]  I. Maxwell,et al.  Cloning, sequence determination, and expression in transfected cells of the coding sequence for the tox 176 attenuated diphtheria toxin A chain , 1987, Molecular and cellular biology.

[18]  P. Dubuc.  The development of obesity, hyperinsulinemia, and hyperglycemia in ob/ob mice. , 1976, Metabolism: clinical and experimental.

[19]  Michael J. Stock,et al.  A role for brown adipose tissue in diet-induced thermogenesis , 1979, Nature.

[20]  D. Cameron,et al.  EFFECTS OF MONOSODIUM GLUTAMATE‐INDUCED OBESITY IN MICE ON CARBOHYDRATE METABOLISM IN INSULIN SECRETION , 1978, Clinical and experimental pharmacology & physiology.

[21]  J. Himms-Hagen,et al.  Increased purine nucleotide binding, altered polypeptide composition, and thermogenesis in brown adipose tissue mitochondria of cold-acclimated rats. , 1978, Canadian journal of biochemistry.

[22]  J. M. Jackson,et al.  ICI D7114 a novel selective β‐adrenoceptor agonist selectively stimulates brown fat and increases whole‐body oxygen consumption , 1991, British journal of pharmacology.

[23]  M. Glotzer,et al.  Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping, and mRNA expression. , 1985, The Journal of biological chemistry.

[24]  L. Kozak,et al.  The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice , 1991, Molecular and cellular biology.