Qingre Huazhuo Jiangsuan Decoction promotes autophagy by inhibiting PI3K/AKT/mTOR signaling pathway to relieve acute gouty arthritis.

[1]  J. Nan,et al.  Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy , 2022, Inflammopharmacology.

[2]  S. Fang,et al.  3β,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy , 2022, Evidence-based complementary and alternative medicine : eCAM.

[3]  Yao Huang,et al.  WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway , 2021, Frontiers in Pharmacology.

[4]  Juan Li,et al.  Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes , 2021, Journal of inflammation research.

[5]  Jixiang Bai,et al.  Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling Pathway , 2021, Evidence-based complementary and alternative medicine : eCAM.

[6]  A. Nadeem,et al.  CXC chemokine receptor 3 antagonist AMG487 shows potent anti-arthritic effects on collagen-induced arthritis by modifying B cell inflammatory profile. , 2020, Immunology letters.

[7]  A. Nadeem,et al.  CXCR3 antagonist AMG487 inhibits glucocorticoid-induced tumor necrosis factor-receptor-related protein and inflammatory mediators in CD45 expressing cells in collagen-induced arthritis mouse model. , 2020, International immunopharmacology.

[8]  Ke Ma,et al.  Chinese herbal medicine for gout: a review of the clinical evidence and pharmacological mechanisms , 2020, Chinese Medicine.

[9]  Jin-Baek Kim,et al.  Anti-Arthritic Activities of Supercritical Carbon Dioxide Extract Derived from Radiation Mutant Perilla Frutescens Var. Crispa in Collagen Antibody-Induced Arthritis , 2019, Nutrients.

[10]  Yili Liang,et al.  Saponins from Clematis mandshurica Rupr. regulates gut microbiota and its metabolites during alleviation of collagen-induced arthritis in rats. , 2019, Pharmacological research.

[11]  X. Yang,et al.  MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling , 2019, Aging.

[12]  Chunfang Zhang,et al.  Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model , 2019, Pharmaceutical biology.

[13]  W. Xie,et al.  Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients , 2019, Inflammopharmacology.

[14]  Mingyuan Liu,et al.  Biochanin a Enhances the Defense Against Salmonella enterica Infection Through AMPK/ULK1/mTOR-Mediated Autophagy and Extracellular Traps and Reversing SPI-1-Dependent Macrophage (MΦ) M2 Polarization , 2018, Front. Cell. Infect. Microbiol..

[15]  Guanghui Wang,et al.  Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[16]  Kathryn E. Crosier,et al.  Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation , 2018, The Journal of clinical investigation.

[17]  Xiaojun Shi,et al.  Physcion 8-O-β-glucopyranoside extracted from Polygonum cuspidatum exhibits anti-proliferative and anti-inflammatory effects on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through the TGF-β/MAPK pathway , 2018, International journal of molecular medicine.

[18]  I. Ganley,et al.  The mammalian ULK1 complex and autophagy initiation , 2017, Essays in biochemistry.

[19]  Wei Sun,et al.  Caffeic acid alleviates inflammatory response in rheumatoid arthritis fibroblast‐like synoviocytes by inhibiting phosphorylation of I&kgr;B kinase &agr;/&bgr; and I&kgr;B&agr; , 2017, International immunopharmacology.

[20]  P. Salomoni,et al.  mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism , 2017, Cell Death and Differentiation.

[21]  Xiao-lin Li,et al.  Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[22]  A. Nadeem,et al.  STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis. , 2017, Immunobiology.

[23]  A. Nadeem,et al.  The tyrosine kinase inhibitor tyrphostin AG126 reduces activation of inflammatory cells and increases Foxp3+ regulatory T cells during pathogenesis of rheumatoid arthritis. , 2016, Molecular immunology.

[24]  A. Chagin.  Effectors of mTOR-autophagy pathway: targeting cancer, affecting the skeleton. , 2016, Current opinion in pharmacology.

[25]  D. Van Assche,et al.  Non-surgical treatments for the management of early osteoarthritis , 2016, Knee Surgery, Sports Traumatology, Arthroscopy.

[26]  Barbara Ankli.  [Current epidemiology of gout]. , 2016, Therapeutische Umschau. Revue therapeutique.

[27]  R. Netea-Maier,et al.  PI3K/Akt/mTOR: A promising therapeutic target for non-medullary thyroid carcinoma. , 2015, Cancer treatment reviews.

[28]  S. Attia,et al.  Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model. , 2014, Cytokine.

[29]  J. Pelletier,et al.  Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis , 2014, Annals of the rheumatic diseases.

[30]  W. Ding,et al.  Role of p62/SQSTM1 in liver physiology and pathogenesis , 2013, Experimental biology and medicine.

[31]  E. Keystone,et al.  TNFα modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts , 2012, Arthritis Research & Therapy.

[32]  T. Vanden Berghe,et al.  Beclin1: A role in membrane dynamics and beyond , 2012, Autophagy.

[33]  R. Xavier,et al.  Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways* , 2011, The Journal of Biological Chemistry.

[34]  A. Cuervo,et al.  Autophagy in the cellular energetic balance. , 2011, Cell metabolism.

[35]  J. Ríos1.  Chemical Constituents and Pharmacological Properties of Poria cocos , 2011, Planta medica.

[36]  R. Thiele,et al.  The pathogenesis of bone erosions in gouty arthritis , 2010, Annals of the rheumatic diseases.

[37]  S. Gygi,et al.  Network organization of the human autophagy system , 2010, Nature.

[38]  A. So.  Developments in the scientific and clinical understanding of gout , 2008, Arthritis research & therapy.

[39]  Daniel J. Klionsky,et al.  Autophagy fights disease through cellular self-digestion , 2008, Nature.

[40]  T. Ueno,et al.  LC3 conjugation system in mammalian autophagy , 2004, The International Journal of Biochemistry & Cell Biology.

[41]  A. Kimchi,et al.  Autophagy as a cell death and tumor suppressor mechanism , 2004, Oncogene.

[42]  P. Wall,et al.  Ankle joint urate arthritis (AJUA) in rats: an alternative animal model of arthritis to that produced by Freund's adjuvant , 1987, Pain.

[43]  Oliver Distler,et al.  Basic and translational research , 2011 .